{"id":"https://openalex.org/W4413935608","doi":"https://doi.org/10.1007/s10822-025-00656-7","title":"Comprehensive analysis of beta-lactamase genes in clinical strains of Escherichia coli and Klebsiella pneumoniae: molecular characterization, and in Silico predictions","display_name":"Comprehensive analysis of beta-lactamase genes in clinical strains of Escherichia coli and Klebsiella pneumoniae: molecular characterization, and in Silico predictions","publication_year":2025,"publication_date":"2025-09-03","ids":{"openalex":"https://openalex.org/W4413935608","doi":"https://doi.org/10.1007/s10822-025-00656-7","pmid":"https://pubmed.ncbi.nlm.nih.gov/40898000"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-025-00656-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-025-00656-7","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067774950","display_name":"C.K.V. Ramesan","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"C. K. V. Ramesan","raw_affiliation_strings":["Department of Microbiology, Sree Narayana College, Kannur, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Sree Narayana College, Kannur, Kerala, India","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040821688","display_name":"Gangaraj Karyath Palliyath","orcid":null},"institutions":[{"id":"https://openalex.org/I2800988382","display_name":"Central Institute of Brackishwater Aquaculture","ror":"https://ror.org/05e7sd388","country_code":"IN","type":"facility","lineage":["https://openalex.org/I179420787","https://openalex.org/I2800988382"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Gangaraj Karyath Palliyath","raw_affiliation_strings":["ICAR-Central Institute of Brackishwater Aquaculture, Chennai, India"],"affiliations":[{"raw_affiliation_string":"ICAR-Central Institute of Brackishwater Aquaculture, Chennai, India","institution_ids":["https://openalex.org/I2800988382"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088333950","display_name":"M. V. Sneha","orcid":null},"institutions":[{"id":"https://openalex.org/I52703040","display_name":"Kannur University","ror":"https://ror.org/00zz2cd87","country_code":"IN","type":"education","lineage":["https://openalex.org/I52703040"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"M. V. Sneha","raw_affiliation_strings":["Department of Biotechnology & Microbiology, Kannur University, Dr. Janaki Ammal Campus, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology & Microbiology, Kannur University, Dr. Janaki Ammal Campus, Kerala, India","institution_ids":["https://openalex.org/I52703040"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023409361","display_name":"K. Sreejith","orcid":null},"institutions":[{"id":"https://openalex.org/I52703040","display_name":"Kannur University","ror":"https://ror.org/00zz2cd87","country_code":"IN","type":"education","lineage":["https://openalex.org/I52703040"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"K. Sreejith","raw_affiliation_strings":["Department of Biotechnology & Microbiology, Kannur University, Dr. Janaki Ammal Campus, Kerala, India. sreejithk@kannuruniv.ac.in","Department of Biotechnology & Microbiology, Kannur University, Dr. Janaki Ammal Campus, Kerala, India"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology & Microbiology, Kannur University, Dr. Janaki Ammal Campus, Kerala, India. sreejithk@kannuruniv.ac.in","institution_ids":[]},{"raw_affiliation_string":"Department of Biotechnology & Microbiology, Kannur University, Dr. Janaki Ammal Campus, Kerala, India","institution_ids":["https://openalex.org/I52703040"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067774950"],"corresponding_institution_ids":[],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.19251109,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"1","first_page":"74","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10419","display_name":"Pharmaceutical and Antibiotic Environmental Impacts","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/2310","display_name":"Pollution"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":0.9059554934501648},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8399143218994141},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.6621889472007751},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.6465157866477966},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5221753120422363},{"id":"https://openalex.org/keywords/beta-lactamase","display_name":"Beta-lactamase","score":0.5056068897247314},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4829961061477661},{"id":"https://openalex.org/keywords/enterobacteriaceae","display_name":"Enterobacteriaceae","score":0.4373435378074646},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.41838428378105164},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30670464038848877}],"concepts":[{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.9059554934501648},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8399143218994141},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6621889472007751},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6465157866477966},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5221753120422363},{"id":"https://openalex.org/C2781288988","wikidata":"https://www.wikidata.org/wiki/Q311379","display_name":"Beta-lactamase","level":4,"score":0.5056068897247314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4829961061477661},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.4373435378074646},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41838428378105164},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30670464038848877}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-025-00656-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-025-00656-7","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:40898000","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40898000","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1998247756","https://openalex.org/W2015115860","https://openalex.org/W2027978582","https://openalex.org/W2080960719","https://openalex.org/W2082535576","https://openalex.org/W2107326708","https://openalex.org/W2126719129","https://openalex.org/W2164863259","https://openalex.org/W2811205980","https://openalex.org/W2925800094","https://openalex.org/W2958094223","https://openalex.org/W3007020664","https://openalex.org/W3023926866","https://openalex.org/W3087318638","https://openalex.org/W3104811569","https://openalex.org/W3110799662","https://openalex.org/W3112882148","https://openalex.org/W3129214182","https://openalex.org/W3149818738","https://openalex.org/W3174180053","https://openalex.org/W3194069003","https://openalex.org/W3209296360","https://openalex.org/W4212841565","https://openalex.org/W4212940766","https://openalex.org/W4220766160","https://openalex.org/W4220992333","https://openalex.org/W4224130224","https://openalex.org/W4229924182","https://openalex.org/W4308194807","https://openalex.org/W4313457127","https://openalex.org/W4405824933"],"related_works":["https://openalex.org/W2388901213","https://openalex.org/W2349850184","https://openalex.org/W3047719118","https://openalex.org/W3089174696","https://openalex.org/W2963257790","https://openalex.org/W1896078995","https://openalex.org/W3198794992","https://openalex.org/W4402436320","https://openalex.org/W2565097120","https://openalex.org/W3148879278"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}