{"id":"https://openalex.org/W4413991626","doi":"https://doi.org/10.1007/s10822-025-00653-w","title":"Protein A-like peptide generation based on generalized diffusion model","display_name":"Protein A-like peptide generation based on generalized diffusion model","publication_year":2025,"publication_date":"2025-09-04","ids":{"openalex":"https://openalex.org/W4413991626","doi":"https://doi.org/10.1007/s10822-025-00653-w","pmid":"https://pubmed.ncbi.nlm.nih.gov/40906240"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-025-00653-w","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-025-00653-w","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102568098","display_name":"Tianqian Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I130541836","display_name":"Beijing Institute of Petrochemical Technology","ror":"https://ror.org/025s55q11","country_code":"CN","type":"education","lineage":["https://openalex.org/I130541836"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Tianqian Zhou","raw_affiliation_strings":["College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China","institution_ids":["https://openalex.org/I130541836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087711303","display_name":"Shibo Zhang","orcid":"https://orcid.org/0009-0009-9656-8517"},"institutions":[{"id":"https://openalex.org/I130541836","display_name":"Beijing Institute of Petrochemical Technology","ror":"https://ror.org/025s55q11","country_code":"CN","type":"education","lineage":["https://openalex.org/I130541836"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shibo Zhang","raw_affiliation_strings":["College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China","institution_ids":["https://openalex.org/I130541836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030718164","display_name":"Huijia Song","orcid":"https://orcid.org/0009-0004-9121-4318"},"institutions":[{"id":"https://openalex.org/I130541836","display_name":"Beijing Institute of Petrochemical Technology","ror":"https://ror.org/025s55q11","country_code":"CN","type":"education","lineage":["https://openalex.org/I130541836"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huijia Song","raw_affiliation_strings":["College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China","institution_ids":["https://openalex.org/I130541836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033323724","display_name":"Qiang He","orcid":"https://orcid.org/0000-0002-6053-9636"},"institutions":[{"id":"https://openalex.org/I130541836","display_name":"Beijing Institute of Petrochemical Technology","ror":"https://ror.org/025s55q11","country_code":"CN","type":"education","lineage":["https://openalex.org/I130541836"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang He","raw_affiliation_strings":["College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China","institution_ids":["https://openalex.org/I130541836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112448331","display_name":"Chun Fang","orcid":null},"institutions":[{"id":"https://openalex.org/I130541836","display_name":"Beijing Institute of Petrochemical Technology","ror":"https://ror.org/025s55q11","country_code":"CN","type":"education","lineage":["https://openalex.org/I130541836"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun Fang","raw_affiliation_strings":["College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China","institution_ids":["https://openalex.org/I130541836"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066133090","display_name":"Xiaozhu Lin","orcid":"https://orcid.org/0009-0000-6234-5627"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaozhu Lin","raw_affiliation_strings":["College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China. lxztg2023@163.com"],"affiliations":[{"raw_affiliation_string":"College of Information Engineering, Beijing Institute of Petrochemical Technology, No. 19 Qingyuan North Road, Daxing District, Beijing, 102617, China. lxztg2023@163.com","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5102568098"],"corresponding_institution_ids":["https://openalex.org/I130541836"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33750339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"1","first_page":"76","last_page":"76"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5441757440567017},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.5337677001953125},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35521289706230164},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3214007318019867},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2812206745147705},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.20959368348121643},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15384328365325928},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.1160239577293396}],"concepts":[{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5441757440567017},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5337677001953125},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35521289706230164},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3214007318019867},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2812206745147705},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.20959368348121643},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15384328365325928},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.1160239577293396}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004058","descriptor_name":"Diffusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-025-00653-w","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-025-00653-w","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:40906240","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40906240","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1556763897","https://openalex.org/W1605294025","https://openalex.org/W1909149576","https://openalex.org/W1995808589","https://openalex.org/W2014337316","https://openalex.org/W2045777307","https://openalex.org/W2066381187","https://openalex.org/W2072404529","https://openalex.org/W2090342034","https://openalex.org/W2097834518","https://openalex.org/W2168938595","https://openalex.org/W2433987067","https://openalex.org/W2519539312","https://openalex.org/W2606439133","https://openalex.org/W2620185010","https://openalex.org/W2735621019","https://openalex.org/W2759860792","https://openalex.org/W2893054519","https://openalex.org/W2898210859","https://openalex.org/W2899747610","https://openalex.org/W2908391177","https://openalex.org/W2944245644","https://openalex.org/W2945929016","https://openalex.org/W2949867299","https://openalex.org/W2963418941","https://openalex.org/W2979549406","https://openalex.org/W2989695108","https://openalex.org/W3038329114","https://openalex.org/W3084236163","https://openalex.org/W3132071138","https://openalex.org/W3135130381","https://openalex.org/W3177828909","https://openalex.org/W3186179742","https://openalex.org/W4223581484","https://openalex.org/W4296032638","https://openalex.org/W4312198153","https://openalex.org/W4383957026","https://openalex.org/W4388694364","https://openalex.org/W4391530977","https://openalex.org/W4396591272","https://openalex.org/W4403603176"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}