{"id":"https://openalex.org/W4379207986","doi":"https://doi.org/10.1007/s10822-023-00510-8","title":"Elucidating the potential effects of point mutations on FGFR3 inhibitor resistance via combined molecular dynamics simulation and community network analysis","display_name":"Elucidating the potential effects of point mutations on FGFR3 inhibitor resistance via combined molecular dynamics simulation and community network analysis","publication_year":2023,"publication_date":"2023-06-03","ids":{"openalex":"https://openalex.org/W4379207986","doi":"https://doi.org/10.1007/s10822-023-00510-8","pmid":"https://pubmed.ncbi.nlm.nih.gov/37269435"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-023-00510-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-023-00510-8","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115587783","display_name":"\u0411\u043e \u041b\u044e","orcid":"https://orcid.org/0000-0003-3045-628X"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Liu","raw_affiliation_strings":["Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China","School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China","institution_ids":["https://openalex.org/I4210123185"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109522975","display_name":"Juntao Ding","orcid":"https://orcid.org/0000-0003-1945-1269"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juntao Ding","raw_affiliation_strings":["Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China","School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China","institution_ids":["https://openalex.org/I4210123185"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101747101","display_name":"Yugang Liu","orcid":"https://orcid.org/0000-0001-5304-3459"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yugang Liu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017441654","display_name":"Jianzhang Wu","orcid":"https://orcid.org/0000-0002-2782-745X"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhang Wu","raw_affiliation_strings":["Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China","School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China","institution_ids":["https://openalex.org/I4210123185"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, 325027, China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I4210086973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100668590","display_name":"Xiaoping Wu","orcid":"https://orcid.org/0000-0002-4198-2210"},"institutions":[{"id":"https://openalex.org/I159948400","display_name":"Jinan University","ror":"https://ror.org/02xe5ns62","country_code":"CN","type":"education","lineage":["https://openalex.org/I159948400"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoping Wu","raw_affiliation_strings":["Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China","MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou, 510632, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]},{"raw_affiliation_string":"MOE Key Laboratory of Tumor Molecular Biology, Jinan University, Guangzhou, 510632, China","institution_ids":["https://openalex.org/I159948400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100428457","display_name":"Qian Chen","orcid":"https://orcid.org/0000-0002-1968-441X"},"institutions":[{"id":"https://openalex.org/I4210105136","display_name":"Yangtze River Delta Physics Research Center (China)","ror":"https://ror.org/01g53qc72","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210105136"]},{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qian Chen","raw_affiliation_strings":["Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314102, China. chenqian200709@163.com","Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314102, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314102, China. chenqian200709@163.com","institution_ids":["https://openalex.org/I4210105136"]},{"raw_affiliation_string":"Future Health Laboratory, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314102, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062336405","display_name":"Wulan Li","orcid":"https://orcid.org/0000-0001-9442-1743"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wulan Li","raw_affiliation_strings":["Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China. lwlwzmu@163.com","School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. lwlwzmu@163.com","The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. lwlwzmu@163.com","Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China. lwlwzmu@163.com","institution_ids":["https://openalex.org/I4210123185"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. lwlwzmu@163.com","institution_ids":["https://openalex.org/I27781120"]},{"raw_affiliation_string":"The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China. lwlwzmu@163.com","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]},{"raw_affiliation_string":"Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Wenzhou, Zhejiang, 325000, China","institution_ids":["https://openalex.org/I4210123185"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5062336405","https://openalex.org/A5100428457"],"corresponding_institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982","https://openalex.org/I4210105136","https://openalex.org/I4210123185","https://openalex.org/I76130692"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04430439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"7","first_page":"325","last_page":"338"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.972000002861023,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-regulation","display_name":"Allosteric regulation","score":0.8185460567474365},{"id":"https://openalex.org/keywords/point-mutation","display_name":"Point mutation","score":0.6951234340667725},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.601904571056366},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5983777046203613},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"Protein kinase domain","score":0.5813683271408081},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.47943419218063354},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.45532655715942383},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.43296343088150024},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.4327990710735321},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3202947974205017},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3006449341773987},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18992173671722412},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.13691619038581848}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8185460567474365},{"id":"https://openalex.org/C176944494","wikidata":"https://www.wikidata.org/wiki/Q1415380","display_name":"Point mutation","level":4,"score":0.6951234340667725},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.601904571056366},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5983777046203613},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.5813683271408081},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.47943419218063354},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.45532655715942383},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43296343088150024},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.4327990710735321},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3202947974205017},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3006449341773987},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18992173671722412},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13691619038581848},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019058","descriptor_name":"Community Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019058","descriptor_name":"Community Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019058","descriptor_name":"Community Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019058","descriptor_name":"Community Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-023-00510-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-023-00510-8","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:37269435","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/37269435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/7","score":0.5,"display_name":"Affordable and clean energy"}],"awards":[{"id":"https://openalex.org/G1205491721","display_name":null,"funder_award_id":"2021A1515011184","funder_id":"https://openalex.org/F4320337111","funder_display_name":"Basic and Applied Basic Research Foundation of Guangdong Province"},{"id":"https://openalex.org/G1954648203","display_name":"\u4ee5FGFR1\u4e3a\u9776\u6807\u7684\u80bd\u884d\u751f\u7269\u8bbe\u8ba1\u4e0e\u6297\u80bf\u7624\u6d3b\u6027\u7814\u7a76","funder_award_id":"81402839","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4283509179","display_name":null,"funder_award_id":"LGF20B020001","funder_id":"https://openalex.org/F4320338464","funder_display_name":"Natural Science Foundation of Zhejiang Province"},{"id":"https://openalex.org/G4923750236","display_name":null,"funder_award_id":"81803580","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320337111","display_name":"Basic and Applied Basic Research Foundation of Guangdong Province","ror":null},{"id":"https://openalex.org/F4320338464","display_name":"Natural Science Foundation of Zhejiang Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W946433493","https://openalex.org/W1031578623","https://openalex.org/W1964758803","https://openalex.org/W1965358479","https://openalex.org/W1966397908","https://openalex.org/W1968984443","https://openalex.org/W1971421925","https://openalex.org/W1977219194","https://openalex.org/W1979702889","https://openalex.org/W1997772366","https://openalex.org/W2016710415","https://openalex.org/W2019711215","https://openalex.org/W2026944977","https://openalex.org/W2056250734","https://openalex.org/W2060433756","https://openalex.org/W2070753604","https://openalex.org/W2088123597","https://openalex.org/W2091013891","https://openalex.org/W2094141392","https://openalex.org/W2095888060","https://openalex.org/W2108604357","https://openalex.org/W2109154308","https://openalex.org/W2112154906","https://openalex.org/W2129213941","https://openalex.org/W2132525235","https://openalex.org/W2139236349","https://openalex.org/W2139560553","https://openalex.org/W2139989191","https://openalex.org/W2153856953","https://openalex.org/W2164242115","https://openalex.org/W2308989383","https://openalex.org/W2329424922","https://openalex.org/W2361360078","https://openalex.org/W2566209015","https://openalex.org/W2566575334","https://openalex.org/W2569264735","https://openalex.org/W2583429502","https://openalex.org/W2595713273","https://openalex.org/W2600889385","https://openalex.org/W2692515715","https://openalex.org/W2768702618","https://openalex.org/W2791297317","https://openalex.org/W2795066068","https://openalex.org/W2804822363","https://openalex.org/W2897841645","https://openalex.org/W2921441004","https://openalex.org/W2946701461","https://openalex.org/W2948387511","https://openalex.org/W3001520065","https://openalex.org/W3006500278","https://openalex.org/W3007750009","https://openalex.org/W3027977667","https://openalex.org/W3032673000","https://openalex.org/W3082770100","https://openalex.org/W3108059695","https://openalex.org/W3159177617","https://openalex.org/W3161074857","https://openalex.org/W3195145409","https://openalex.org/W3209811467","https://openalex.org/W3210203870","https://openalex.org/W3215097640","https://openalex.org/W4210370823","https://openalex.org/W4213090323","https://openalex.org/W4220871042","https://openalex.org/W4220942461","https://openalex.org/W4225514393","https://openalex.org/W4225515641","https://openalex.org/W4253191544","https://openalex.org/W6931429467"],"related_works":["https://openalex.org/W2465407223","https://openalex.org/W2037589400","https://openalex.org/W2619226366","https://openalex.org/W1971516615","https://openalex.org/W2974197009","https://openalex.org/W2388585719","https://openalex.org/W2620843825","https://openalex.org/W4321367641","https://openalex.org/W2741879051","https://openalex.org/W2358978455"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}