{"id":"https://openalex.org/W36494599","doi":"https://doi.org/10.1007/s10822-022-00491-0","title":"Integration of Biological Data on Transcriptome","display_name":"Integration of Biological Data on Transcriptome","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W36494599","doi":"https://doi.org/10.1007/s10822-022-00491-0","mag":"36494599"},"language":"en","primary_location":{"id":"mag:36494599","is_oa":false,"landing_page_url":"https://hal.inria.fr/hal-01856201","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},"type":"preprint","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091872345","display_name":"Laure Berti\u2010\u00c9quille","orcid":"https://orcid.org/0000-0002-8046-0570"},"institutions":[{"id":"https://openalex.org/I2802519937","display_name":"Institut de Recherche en Informatique et Syst\u00e8mes Al\u00e9atoires","ror":"https://ror.org/00myn0z94","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I205703379","https://openalex.org/I2802204017","https://openalex.org/I2802519937","https://openalex.org/I28221208","https://openalex.org/I4210127572","https://openalex.org/I4210159245","https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laure Berti\u2010\u00c9quille","raw_affiliation_strings":["Institut de Recherche en Informatique et Syst\u00e8mes Al\u00e9atoires"],"raw_orcid":"https://orcid.org/0000-0002-8046-0570","affiliations":[{"raw_affiliation_string":"Institut de Recherche en Informatique et Syst\u00e8mes Al\u00e9atoires","institution_ids":["https://openalex.org/I2802519937"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109536646","display_name":"Fouzia Moussouni","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138914","display_name":"Foie, M\u00e9tabolisme, Cancer","ror":"https://ror.org/03z69yv22","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I4210138914","https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fouzia Moussouni","raw_affiliation_strings":["Foie, m\u00e9tabolismes et cancer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foie, m\u00e9tabolismes et cancer","institution_ids":["https://openalex.org/I4210138914"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000316410","display_name":"A. Arcade","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Arcade","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"37","issue":"2","first_page":"75","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10215","display_name":"Semantic Web and Ontologies","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.993399977684021,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10538","display_name":"Data Mining Algorithms and Applications","score":0.9763000011444092,"subfield":{"id":"https://openalex.org/subfields/1710","display_name":"Information Systems"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.7164486050605774},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5199804902076721},{"id":"https://openalex.org/keywords/data-integration","display_name":"Data integration","score":0.4367445111274719},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3675515651702881},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3647066354751587},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.20479565858840942},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12018576264381409},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.08730420470237732},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07083863019943237}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7164486050605774},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5199804902076721},{"id":"https://openalex.org/C72634772","wikidata":"https://www.wikidata.org/wiki/Q386824","display_name":"Data integration","level":2,"score":0.4367445111274719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3675515651702881},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3647066354751587},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.20479565858840942},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12018576264381409},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.08730420470237732},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07083863019943237}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:36494599","is_oa":false,"landing_page_url":"https://hal.inria.fr/hal-01856201","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"HAL (Le Centre pour la Communication Scientifique Directe)","raw_type":null},{"id":"pmh:oai:HAL:hal-01856201v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-01856201","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Revue des Sciences et Technologies de l'Information - S\u00e9rie ISI : Ing\u00e9nierie des Syst\u00e8mes d'Information, 2001, Num\u00e9ro Sp\u00e9cial \u201cInterop\u00e9rabilit\u00e9 et Int\u00e9gration des Syst\u00e8mes d\u2019Information\u201d, 6 (3/2001), pp.61-86","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3739308504","display_name":null,"funder_award_id":"PICT 2017-0643","funder_id":"https://openalex.org/F4320331467","funder_display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n"},{"id":"https://openalex.org/G531388536","display_name":null,"funder_award_id":"PICT 2018- 01124","funder_id":"https://openalex.org/F4320331467","funder_display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n"},{"id":"https://openalex.org/G8871323487","display_name":null,"funder_award_id":"PIP2015-0733","funder_id":"https://openalex.org/F4320321594","funder_display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas"}],"funders":[{"id":"https://openalex.org/F4320321594","display_name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","ror":"https://ror.org/03cqe8w59"},{"id":"https://openalex.org/F4320322227","display_name":"Universidad Nacional de La Plata","ror":"https://ror.org/01tjs6929"},{"id":"https://openalex.org/F4320331467","display_name":"Agencia Nacional de Promoci\u00f3n de la Investigaci\u00f3n, el Desarrollo Tecnol\u00f3gico y la Innovaci\u00f3n","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W1191765818","https://openalex.org/W1772241369","https://openalex.org/W1879587332","https://openalex.org/W1965145175","https://openalex.org/W1968134256","https://openalex.org/W1968340466","https://openalex.org/W1969189143","https://openalex.org/W1971189041","https://openalex.org/W1971372565","https://openalex.org/W1972241288","https://openalex.org/W1975718050","https://openalex.org/W1976392306","https://openalex.org/W1981164101","https://openalex.org/W1983735604","https://openalex.org/W1990771438","https://openalex.org/W2010847001","https://openalex.org/W2021520922","https://openalex.org/W2024602785","https://openalex.org/W2026107326","https://openalex.org/W2027605433","https://openalex.org/W2028629022","https://openalex.org/W2032619490","https://openalex.org/W2036011280","https://openalex.org/W2047399603","https://openalex.org/W2051210555","https://openalex.org/W2057119505","https://openalex.org/W2064204242","https://openalex.org/W2074681440","https://openalex.org/W2077015857","https://openalex.org/W2080402044","https://openalex.org/W2080444880","https://openalex.org/W2081048133","https://openalex.org/W2085891570","https://openalex.org/W2087466582","https://openalex.org/W2088321706","https://openalex.org/W2091950883","https://openalex.org/W2095036253","https://openalex.org/W2098917521","https://openalex.org/W2100121002","https://openalex.org/W2101694231","https://openalex.org/W2102294561","https://openalex.org/W2103017472","https://openalex.org/W2103325328","https://openalex.org/W2104273909","https://openalex.org/W2108389384","https://openalex.org/W2110252279","https://openalex.org/W2111823792","https://openalex.org/W2112404637","https://openalex.org/W2113336835","https://openalex.org/W2116825089","https://openalex.org/W2117846173","https://openalex.org/W2118233996","https://openalex.org/W2120615294","https://openalex.org/W2132629607","https://openalex.org/W2137420916","https://openalex.org/W2139881678","https://openalex.org/W2142266168","https://openalex.org/W2148984584","https://openalex.org/W2150853746","https://openalex.org/W2156119816","https://openalex.org/W2157739137","https://openalex.org/W2158698691","https://openalex.org/W2159958100","https://openalex.org/W2166179139","https://openalex.org/W2168605051","https://openalex.org/W2178520680","https://openalex.org/W2179434159","https://openalex.org/W2284406862","https://openalex.org/W2414062173","https://openalex.org/W2507304759","https://openalex.org/W2550887636","https://openalex.org/W2555103584","https://openalex.org/W2573464717","https://openalex.org/W2596554402","https://openalex.org/W2757641730","https://openalex.org/W2767891136","https://openalex.org/W2791813077","https://openalex.org/W2792867913","https://openalex.org/W2793609032","https://openalex.org/W2801532944","https://openalex.org/W2894284892","https://openalex.org/W2947216665","https://openalex.org/W2980436508","https://openalex.org/W2988372912","https://openalex.org/W2989052455","https://openalex.org/W3035107183","https://openalex.org/W3120361527","https://openalex.org/W3135534391","https://openalex.org/W3136918052","https://openalex.org/W3180770757","https://openalex.org/W3192476198","https://openalex.org/W4211196614","https://openalex.org/W4288081037"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W2151865869","https://openalex.org/W3155641129"],"abstract_inverted_index":{"Chagas":[0],"disease,":[1],"also":[2],"known":[3,133],"as":[4,135],"American":[5],"trypanosomiasis,":[6],"is":[7],"a":[8,73,106,126],"neglected":[9],"tropical":[10],"disease":[11],"caused":[12],"by":[13,51,93],"the":[14,25,49,78,104,166,170,175,192,196,201],"protozoa":[15],"Trypanosoma":[16],"cruzi,":[17,84],"affecting":[18],"nearly":[19],"7":[20],"million":[21],"people":[22],"only":[23],"in":[24,125,141,152,162,191],"Americas.":[26],"Polyamines":[27],"are":[28,40],"essential":[29],"compounds":[30,116,137],"for":[31,42,151],"parasite":[32],"growth,":[33],"survival,":[34],"and":[35,90,114,119,147,155,183,185,200],"differentiation.":[36],"However,":[37],"because":[38],"trypanosomatids":[39],"auxotrophic":[41],"polyamines,":[43],"they":[44],"must":[45],"be":[46],"obtained":[47],"from":[48,103],"host":[50],"specific":[52],"transporters.":[53],"In":[54],"this":[55],"investigation,":[56],"an":[57],"ensemble":[58],"of":[59,77,82,157,169,198,204],"QSAR":[60],"classifiers":[61],"able":[62,109,188],"to":[63,110,131,179,189],"identify":[64],"polyamine":[65,80,139],"analogs":[66],"with":[67,88],"trypanocidal":[68],"activity":[69],"was":[70,86,117],"developed.":[71],"Then,":[72],"multi-template":[74],"homology":[75],"model":[76,108],"dimeric":[79],"transporter":[81],"T.":[83,142],"TcPAT12,":[85],"created":[87],"Rosetta,":[89],"then":[91],"refined":[92],"enhanced":[94],"sampling":[95],"molecular":[96],"dynamics":[97],"simulations.":[98],"Using":[99],"representative":[100],"snapshots":[101],"extracted":[102],"trajectory,":[105],"docking":[107],"discriminate":[111],"between":[112],"active":[113],"inactive":[115],"developed":[118],"validated.":[120],"Both":[121],"models":[122],"were":[123,149,187],"applied":[124],"parallel":[127],"virtual":[128],"screening":[129],"campaign":[130],"repurpose":[132],"drugs":[134],"anti-trypanosomal":[136],"inhibiting":[138],"transport":[140],"cruzi.":[143],"Montelukast,":[144],"Quinestrol,":[145],"Danazol,":[146],"Dutasteride":[148],"selected":[150],"vitro":[153],"testing,":[154],"all":[156,174],"them":[158],"inhibited":[159],"putrescine":[160],"uptake":[161],"biochemical":[163],"assays,":[164],"confirming":[165],"predictive":[167],"ability":[168],"computational":[171],"models.":[172],"Furthermore,":[173],"confirmed":[176],"hits":[177],"proved":[178],"inhibit":[180],"epimastigote":[181],"proliferation,":[182],"Quinestrol":[184],"Danazol":[186],"inhibit,":[190],"low":[193],"micromolar":[194],"range,":[195],"viability":[197],"trypomastigotes":[199],"intracellular":[202],"growth":[203],"amastigotes.":[205]},"counts_by_year":[],"updated_date":"2025-10-10T17:16:08.811792","created_date":"2025-10-10T00:00:00"}
