{"id":"https://openalex.org/W2990585915","doi":"https://doi.org/10.1007/s10822-019-00255-3","title":"Undersampling: case studies of flaviviral inhibitory activities","display_name":"Undersampling: case studies of flaviviral inhibitory activities","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W2990585915","doi":"https://doi.org/10.1007/s10822-019-00255-3","mag":"2990585915","pmid":"https://pubmed.ncbi.nlm.nih.gov/31773464"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-019-00255-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-019-00255-3","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020444039","display_name":"Stephen J. Barigye","orcid":"https://orcid.org/0000-0003-3547-8293"},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Stephen J. Barigye","raw_affiliation_strings":["Departamento de Qu\u00edmica F\u00edsica Aplicada, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM), 28049, Madrid, Spain. sjbarigye@gmail.com","Departamento de Qu\u00edmica F\u00edsica Aplicada, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM), 28049, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3547-8293","affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica F\u00edsica Aplicada, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM), 28049, Madrid, Spain. sjbarigye@gmail.com","institution_ids":["https://openalex.org/I63634437"]},{"raw_affiliation_string":"Departamento de Qu\u00edmica F\u00edsica Aplicada, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM), 28049, Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017047972","display_name":"Jos\u00e9 M. Garc\u0131\u0301a de la Vega","orcid":"https://orcid.org/0000-0002-1940-422X"},"institutions":[{"id":"https://openalex.org/I63634437","display_name":"Universidad Aut\u00f3noma de Madrid","ror":"https://ror.org/01cby8j38","country_code":"ES","type":"education","lineage":["https://openalex.org/I63634437"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Manuel Garc\u00eda de la Vega","raw_affiliation_strings":["Departamento de Qu\u00edmica F\u00edsica Aplicada, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM), 28049, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica F\u00edsica Aplicada, Facultad de Ciencias, Universidad Aut\u00f3noma de Madrid (UAM), 28049, Madrid, Spain","institution_ids":["https://openalex.org/I63634437"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010759353","display_name":"Juan A. Castillo\u2010Garit","orcid":"https://orcid.org/0000-0003-0896-9484"},"institutions":[{"id":"https://openalex.org/I4387155226","display_name":"Universidad de Ciencias M\u00e9dicas de Villa Clara","ror":"https://ror.org/02rbemf16","country_code":null,"type":"education","lineage":["https://openalex.org/I4387155226"]}],"countries":["CU"],"is_corresponding":false,"raw_author_name":"Juan A. Castillo-Garit","raw_affiliation_strings":["Unidad de Toxicolog\u00eda Experimental, Universidad de Ciencias M\u00e9dicas de Villa Clara, 50200, Santa Clara, Villa Clara, Cuba"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Toxicolog\u00eda Experimental, Universidad de Ciencias M\u00e9dicas de Villa Clara, 50200, Santa Clara, Villa Clara, Cuba","institution_ids":["https://openalex.org/I4387155226"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5020444039"],"corresponding_institution_ids":["https://openalex.org/I63634437"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":1.2752,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.81178123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"33","issue":"11","first_page":"997","last_page":"1008"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.9890000224113464,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9857000112533569,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/undersampling","display_name":"Undersampling","score":0.7405635118484497},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6183807849884033},{"id":"https://openalex.org/keywords/pruning","display_name":"Pruning","score":0.48038560152053833},{"id":"https://openalex.org/keywords/test-set","display_name":"Test set","score":0.41967350244522095},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.41127991676330566},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.40431681275367737},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3907069265842438},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2112956941127777}],"concepts":[{"id":"https://openalex.org/C136536468","wikidata":"https://www.wikidata.org/wiki/Q1225894","display_name":"Undersampling","level":2,"score":0.7405635118484497},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6183807849884033},{"id":"https://openalex.org/C108010975","wikidata":"https://www.wikidata.org/wiki/Q500094","display_name":"Pruning","level":2,"score":0.48038560152053833},{"id":"https://openalex.org/C169903167","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Test set","level":2,"score":0.41967350244522095},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.41127991676330566},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.40431681275367737},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3907069265842438},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2112956941127777},{"id":"https://openalex.org/C6557445","wikidata":"https://www.wikidata.org/wiki/Q173113","display_name":"Agronomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000071244","descriptor_name":"Zika Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003716","descriptor_name":"Dengue Virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014902","descriptor_name":"West Nile virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014902","descriptor_name":"West Nile virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014902","descriptor_name":"West Nile virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018067","descriptor_name":"Flaviviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018067","descriptor_name":"Flaviviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018067","descriptor_name":"Flaviviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018178","descriptor_name":"Flaviviridae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018178","descriptor_name":"Flaviviridae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018178","descriptor_name":"Flaviviridae Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-019-00255-3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-019-00255-3","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:31773464","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31773464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5400000214576721,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W85350352","https://openalex.org/W571200655","https://openalex.org/W1563554545","https://openalex.org/W1663154925","https://openalex.org/W1899644141","https://openalex.org/W1965427641","https://openalex.org/W1977375280","https://openalex.org/W1988963904","https://openalex.org/W2006311198","https://openalex.org/W2016591040","https://openalex.org/W2025223367","https://openalex.org/W2039412159","https://openalex.org/W2043906184","https://openalex.org/W2053490656","https://openalex.org/W2079103525","https://openalex.org/W2084063333","https://openalex.org/W2090110922","https://openalex.org/W2095151209","https://openalex.org/W2116471574","https://openalex.org/W2123179625","https://openalex.org/W2131222241","https://openalex.org/W2144451477","https://openalex.org/W2148933468","https://openalex.org/W2290337285","https://openalex.org/W2411703760","https://openalex.org/W2514790758","https://openalex.org/W2544836728","https://openalex.org/W2620298867","https://openalex.org/W2774750632","https://openalex.org/W2780505025","https://openalex.org/W2781902417","https://openalex.org/W2811335676","https://openalex.org/W2897069058","https://openalex.org/W3021145540","https://openalex.org/W3155649056","https://openalex.org/W4210890186","https://openalex.org/W4243367342"],"related_works":["https://openalex.org/W2109073422","https://openalex.org/W2887783772","https://openalex.org/W2101754595","https://openalex.org/W4249381695","https://openalex.org/W2534887053","https://openalex.org/W2026172757","https://openalex.org/W2080076470","https://openalex.org/W4389292014","https://openalex.org/W3151592636","https://openalex.org/W4249288098"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-08-09T07:27:16.801131","created_date":"2019-12-05T00:00:00"}