{"id":"https://openalex.org/W2742993207","doi":"https://doi.org/10.1007/s10822-017-0039-0","title":"Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure\u2013activity relationship studies","display_name":"Development of a pharmacophore for cruzain using oxadiazoles as virtual molecular probes: quantitative structure\u2013activity relationship studies","publication_year":2017,"publication_date":"2017-08-09","ids":{"openalex":"https://openalex.org/W2742993207","doi":"https://doi.org/10.1007/s10822-017-0039-0","mag":"2742993207","pmid":"https://pubmed.ncbi.nlm.nih.gov/28795372"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-017-0039-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-017-0039-0","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://dx.doi.org/10.1007/s10822-017-0039-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088855094","display_name":"Anacleto Silva de Souza","orcid":"https://orcid.org/0000-0002-5669-1723"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Anacleto S. de Souza","raw_affiliation_strings":["Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073916197","display_name":"Marcelo Tavares de Oliveira","orcid":null},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marcelo T. de Oliveira","raw_affiliation_strings":["Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Trabalhador s\u00e3o-carlense 400, S\u00e3o Carlos, SP, 13566-590, Brazil","Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Qu\u00edmica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Trabalhador s\u00e3o-carlense 400, S\u00e3o Carlos, SP, 13566-590, Brazil","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012731266","display_name":"Adriano D. Andricopulo","orcid":"https://orcid.org/0000-0002-0457-818X"},"institutions":[{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriano D. Andricopulo","raw_affiliation_strings":["Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil. aandrico@ifsc.usp.br","Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil. aandrico@ifsc.usp.br","institution_ids":["https://openalex.org/I17974374"]},{"raw_affiliation_string":"Laborat\u00f3rio de Qu\u00edmica Medicinal e Computacional, Centro de Pesquisa e Inova\u00e7\u00e3o em Biodiversidade e F\u00e1rmacos, Instituto de F\u00edsica de S\u00e3o Carlos, Universidade de S\u00e3o Paulo, Avenida Jo\u00e3o Dagnone 1100, S\u00e3o Carlos, SP, 13563-120, Brazil","institution_ids":["https://openalex.org/I17974374"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I17974374"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":1.3095,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80368704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"31","issue":"9","first_page":"801","last_page":"816"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13160","display_name":"Synthesis and Biological Evaluation","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacophore","display_name":"Pharmacophore","score":0.9404749274253845},{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.835776686668396},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.7793936729431152},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.5610856413841248},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4751960039138794},{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.45783331990242004},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.44285932183265686},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.41699349880218506},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39606133103370667},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.3933875262737274},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.3392651677131653},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.29305148124694824},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.2752573788166046},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.09753528237342834},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.08019000291824341},{"id":"https://openalex.org/keywords/parasite-hosting","display_name":"Parasite hosting","score":0.0757189691066742}],"concepts":[{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.9404749274253845},{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.835776686668396},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.7793936729431152},{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.5610856413841248},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4751960039138794},{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.45783331990242004},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.44285932183265686},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.41699349880218506},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39606133103370667},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3933875262737274},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3392651677131653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29305148124694824},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2752573788166046},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09753528237342834},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.08019000291824341},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.0757189691066742},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011789","descriptor_name":"Quantum Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011789","descriptor_name":"Quantum Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011789","descriptor_name":"Quantum Theory","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014344","descriptor_name":"Trypanocidal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D021281","descriptor_name":"Quantitative Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10822-017-0039-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-017-0039-0","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:28795372","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28795372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null},{"id":"pmh:002855125","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s10822-017-0039-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP (Biblioteca Digital da Produ\u00e7\u00e3o Intelectual)","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":{"id":"pmh:002855125","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1007/s10822-017-0039-0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da USP (Biblioteca Digital da Produ\u00e7\u00e3o Intelectual)","raw_type":"info:eu-repo/semantics/publishedVersion"},"sustainable_development_goals":[{"score":0.6100000143051147,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W1718587718","https://openalex.org/W1965633191","https://openalex.org/W1969437916","https://openalex.org/W1974880836","https://openalex.org/W1977939709","https://openalex.org/W1981156641","https://openalex.org/W1982346259","https://openalex.org/W1985588649","https://openalex.org/W1987788200","https://openalex.org/W1992041755","https://openalex.org/W1992805793","https://openalex.org/W1999353322","https://openalex.org/W2000815209","https://openalex.org/W2009423060","https://openalex.org/W2019013946","https://openalex.org/W2021981535","https://openalex.org/W2026587946","https://openalex.org/W2031168104","https://openalex.org/W2033757486","https://openalex.org/W2036668937","https://openalex.org/W2051395326","https://openalex.org/W2053550167","https://openalex.org/W2054030396","https://openalex.org/W2054912933","https://openalex.org/W2059765043","https://openalex.org/W2064912701","https://openalex.org/W2071223559","https://openalex.org/W2081218931","https://openalex.org/W2081906538","https://openalex.org/W2085313140","https://openalex.org/W2085332552","https://openalex.org/W2086729168","https://openalex.org/W2086895937","https://openalex.org/W2090971258","https://openalex.org/W2094742663","https://openalex.org/W2097472327","https://openalex.org/W2102377211","https://openalex.org/W2102403893","https://openalex.org/W2107923755","https://openalex.org/W2115123186","https://openalex.org/W2121485164","https://openalex.org/W2126522147","https://openalex.org/W2130312681","https://openalex.org/W2132629607","https://openalex.org/W2146216242","https://openalex.org/W2147084679","https://openalex.org/W2149976637","https://openalex.org/W2161573959","https://openalex.org/W2164678530","https://openalex.org/W2171991995","https://openalex.org/W2217770415","https://openalex.org/W2222589778","https://openalex.org/W2265596863","https://openalex.org/W2321151770","https://openalex.org/W2327438214","https://openalex.org/W2482147576","https://openalex.org/W2525356667","https://openalex.org/W2580427101","https://openalex.org/W2586932891","https://openalex.org/W2617152103","https://openalex.org/W2621551068","https://openalex.org/W2951273027","https://openalex.org/W4210980497","https://openalex.org/W4235938477"],"related_works":["https://openalex.org/W2000397010","https://openalex.org/W2059558045","https://openalex.org/W2115078847","https://openalex.org/W2314430254","https://openalex.org/W2021051369","https://openalex.org/W3009723507","https://openalex.org/W2333220762","https://openalex.org/W2080809815","https://openalex.org/W2062768126","https://openalex.org/W1966048654"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-07-25T05:54:39.514286","created_date":"2025-10-10T00:00:00"}