{"id":"https://openalex.org/W1987929383","doi":"https://doi.org/10.1007/s10822-015-9841-8","title":"Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3)","display_name":"Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3)","publication_year":2015,"publication_date":"2015-03-25","ids":{"openalex":"https://openalex.org/W1987929383","doi":"https://doi.org/10.1007/s10822-015-9841-8","mag":"1987929383","pmid":"https://pubmed.ncbi.nlm.nih.gov/25808135"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-015-9841-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-015-9841-8","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047350976","display_name":"Yan Li","orcid":"https://orcid.org/0000-0002-9402-1093"},"institutions":[{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN","FR"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Department of Chemistry, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China","Univ Paris Diderot, Sorbonne Paris Cit\u00e9","Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"Univ Paris Diderot, Sorbonne Paris Cit\u00e9","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"raw_affiliation_string":"Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037733419","display_name":"Michel Delamar","orcid":null},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210124942","display_name":"Interfaces Traitements Organisation et Dynamique des Syst\u00e8mes","ror":"https://ror.org/03edms940","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210124942","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Michel Delamar","raw_affiliation_strings":["ITODYS, UMR CNRS 7086, Univ Paris Diderot, Sorbonne Paris Cit\u00e9, 15 rue J-A. de Ba\u00eff, 75013, Paris, France","University Paris Diderot Sorbonne Paris Cit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITODYS, UMR CNRS 7086, Univ Paris Diderot, Sorbonne Paris Cit\u00e9, 15 rue J-A. de Ba\u00eff, 75013, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I169173203","https://openalex.org/I204730241","https://openalex.org/I4210091437","https://openalex.org/I4210124942"]},{"raw_affiliation_string":"University Paris Diderot Sorbonne Paris Cit\u00e9","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028990485","display_name":"Patricia Busca","orcid":"https://orcid.org/0000-0003-1284-8183"},"institutions":[{"id":"https://openalex.org/I110736937","display_name":"D\u00e9l\u00e9gation Paris 5","ror":"https://ror.org/02e0y6e06","country_code":"FR","type":"government","lineage":["https://openalex.org/I110736937","https://openalex.org/I154526488"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210117082","display_name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques","ror":"https://ror.org/028qedy27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210117082","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patricia Busca","raw_affiliation_strings":["UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75006, Paris, France","Universit\u00e8 Paris Descartes#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75006, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210117082"]},{"raw_affiliation_string":"Universit\u00e8 Paris Descartes#TAB#","institution_ids":["https://openalex.org/I110736937","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031620212","display_name":"Guillaume Prestat","orcid":"https://orcid.org/0000-0002-3948-1476"},"institutions":[{"id":"https://openalex.org/I110736937","display_name":"D\u00e9l\u00e9gation Paris 5","ror":"https://ror.org/02e0y6e06","country_code":"FR","type":"government","lineage":["https://openalex.org/I110736937","https://openalex.org/I154526488"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210117082","display_name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques","ror":"https://ror.org/028qedy27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210117082","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Guillaume Prestat","raw_affiliation_strings":["UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75006, Paris, France","Universit\u00e8 Paris Descartes#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75006, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210117082"]},{"raw_affiliation_string":"Universit\u00e8 Paris Descartes#TAB#","institution_ids":["https://openalex.org/I110736937","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067144203","display_name":"Laurent Le Corre","orcid":"https://orcid.org/0000-0002-0136-8072"},"institutions":[{"id":"https://openalex.org/I110736937","display_name":"D\u00e9l\u00e9gation Paris 5","ror":"https://ror.org/02e0y6e06","country_code":"FR","type":"government","lineage":["https://openalex.org/I110736937","https://openalex.org/I154526488"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210117082","display_name":"Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques","ror":"https://ror.org/028qedy27","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210117082","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurent Le Corre","raw_affiliation_strings":["UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75006, Paris, France","Universit\u00e8 Paris Descartes#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UMR 8601 CNRS, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Universit\u00e9 Paris Descartes, 45 rue des Saints-P\u00e8res, 75006, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210117082"]},{"raw_affiliation_string":"Universit\u00e8 Paris Descartes#TAB#","institution_ids":["https://openalex.org/I110736937","https://openalex.org/I204730241"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012453905","display_name":"Laurence Legeai\u2010Mallet","orcid":"https://orcid.org/0000-0003-4989-5856"},"institutions":[{"id":"https://openalex.org/I110736937","display_name":"D\u00e9l\u00e9gation Paris 5","ror":"https://ror.org/02e0y6e06","country_code":"FR","type":"government","lineage":["https://openalex.org/I110736937","https://openalex.org/I154526488"]},{"id":"https://openalex.org/I1288880153","display_name":"H\u00f4pital Necker-Enfants Malades","ror":"https://ror.org/05tr67282","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I1288880153","https://openalex.org/I4210097159","https://openalex.org/I4210120235"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Legeai-Mallet","raw_affiliation_strings":["INSERM U781, Institut Imagine, H\u00f4pital Necker-Enfants Malades, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 156 rue Vaugirard, Paris, France","Universit\u00e9 Paris-Descartes, Sorbonne-Paris-Cit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U781, Institut Imagine, H\u00f4pital Necker-Enfants Malades, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, 156 rue Vaugirard, Paris, France","institution_ids":["https://openalex.org/I1288880153","https://openalex.org/I154526488","https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Descartes, Sorbonne-Paris-Cit\u00e9","institution_ids":["https://openalex.org/I110736937","https://openalex.org/I204730241","https://openalex.org/I4210091437"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018969310","display_name":"Rongjing Hu","orcid":null},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"RongJing Hu","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, Lanzhou, 730000, Gansu, People\u2019s Republic of China","[Lanzhou University]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, Lanzhou, 730000, Gansu, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"[Lanzhou University]","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088612057","display_name":"Ruisheng Zhang","orcid":"https://orcid.org/0000-0002-6585-2656"},"institutions":[{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruisheng Zhang","raw_affiliation_strings":["School of Information Science and Engineering, Lanzhou University, Lanzhou, 730000, Gansu, People\u2019s Republic of China","[Lanzhou University]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Information Science and Engineering, Lanzhou University, Lanzhou, 730000, Gansu, People\u2019s Republic of China","institution_ids":["https://openalex.org/I76214153"]},{"raw_affiliation_string":"[Lanzhou University]","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006974082","display_name":"Florent Barbault","orcid":"https://orcid.org/0000-0002-6082-3194"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I169173203","display_name":"D\u00e9l\u00e9gation Paris 7","ror":"https://ror.org/00bw5n526","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488","https://openalex.org/I169173203"]},{"id":"https://openalex.org/I204730241","display_name":"Universit\u00e9 Paris Cit\u00e9","ror":"https://ror.org/05f82e368","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4210124942","display_name":"Interfaces Traitements Organisation et Dynamique des Syst\u00e8mes","ror":"https://ror.org/03edms940","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210124942","https://openalex.org/I4210128300"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Florent Barbault","raw_affiliation_strings":["ITODYS, UMR CNRS 7086, Univ Paris Diderot, Sorbonne Paris Cit\u00e9, 15 rue J-A. de Ba\u00eff, 75013, Paris, France","University Paris Diderot Sorbonne Paris Cit\u00e9"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ITODYS, UMR CNRS 7086, Univ Paris Diderot, Sorbonne Paris Cit\u00e9, 15 rue J-A. de Ba\u00eff, 75013, Paris, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I169173203","https://openalex.org/I204730241","https://openalex.org/I4210091437","https://openalex.org/I4210124942"]},{"raw_affiliation_string":"University Paris Diderot Sorbonne Paris Cit\u00e9","institution_ids":["https://openalex.org/I169173203","https://openalex.org/I204730241"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5006974082"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I169173203","https://openalex.org/I204730241","https://openalex.org/I4210091437","https://openalex.org/I4210124942"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.2755,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.58461365,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"29","issue":"7","first_page":"619","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.9782999753952026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"Fibroblast growth factor receptor","score":0.709191620349884},{"id":"https://openalex.org/keywords/protein-kinase-domain","display_name":"Protein kinase domain","score":0.6062339544296265},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"Tyrosine kinase","score":0.5614846348762512},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase","display_name":"Receptor tyrosine kinase","score":0.553193211555481},{"id":"https://openalex.org/keywords/kinase","display_name":"Kinase","score":0.5416856408119202},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5011622905731201},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.4329821467399597},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.43261903524398804},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.4090803861618042},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3778807520866394},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3224426507949829},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.2994433641433716},{"id":"https://openalex.org/keywords/fibroblast-growth-factor","display_name":"Fibroblast growth factor","score":0.2965390682220459},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.2142724096775055},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09518596529960632}],"concepts":[{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.709191620349884},{"id":"https://openalex.org/C32619005","wikidata":"https://www.wikidata.org/wiki/Q24768234","display_name":"Protein kinase domain","level":4,"score":0.6062339544296265},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5614846348762512},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.553193211555481},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5416856408119202},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5011622905731201},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4329821467399597},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.43261903524398804},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4090803861618042},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3778807520866394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3224426507949829},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2994433641433716},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.2965390682220459},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.2142724096775055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09518596529960632},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051498","descriptor_name":"Receptor, Fibroblast Growth Factor, Type 3","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s10822-015-9841-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-015-9841-8","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:25808135","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25808135","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null},{"id":"pmh:oai:ir.lzu.edu.cn/:262010/180103","is_oa":false,"landing_page_url":"http://ir.lzu.edu.cn/handle/262010/180103","pdf_url":null,"source":{"id":"https://openalex.org/S4406923049","display_name":"Lanzhou University Institutional Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:HAL:hal-05573984v1","is_oa":false,"landing_page_url":"https://hal.science/hal-05573984","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Computer-Aided Molecular Design, 2015, 29 (7), pp.619-641. ⟨10.1007/s10822-015-9841-8⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.550000011920929}],"awards":[],"funders":[{"id":"https://openalex.org/F4320314140","display_name":"Family Process Institute","ror":null},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"},{"id":"https://openalex.org/F4320326256","display_name":"Grand \u00c9quipement National De Calcul Intensif","ror":"https://ror.org/0010d1q40"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":77,"referenced_works":["https://openalex.org/W1579594936","https://openalex.org/W1581793857","https://openalex.org/W1600771042","https://openalex.org/W1963822859","https://openalex.org/W1964704093","https://openalex.org/W1969231606","https://openalex.org/W1969723894","https://openalex.org/W1972450017","https://openalex.org/W1973060079","https://openalex.org/W1974625510","https://openalex.org/W1975580333","https://openalex.org/W1978607920","https://openalex.org/W1983401069","https://openalex.org/W1992282177","https://openalex.org/W1992834064","https://openalex.org/W1992945955","https://openalex.org/W1994105285","https://openalex.org/W1997801790","https://openalex.org/W1999005083","https://openalex.org/W2005011965","https://openalex.org/W2006472263","https://openalex.org/W2008923823","https://openalex.org/W2013836123","https://openalex.org/W2014582878","https://openalex.org/W2016155858","https://openalex.org/W2020293198","https://openalex.org/W2021019774","https://openalex.org/W2026418335","https://openalex.org/W2027515486","https://openalex.org/W2030205108","https://openalex.org/W2030435135","https://openalex.org/W2036579888","https://openalex.org/W2036851890","https://openalex.org/W2037535298","https://openalex.org/W2039866699","https://openalex.org/W2040232982","https://openalex.org/W2040335954","https://openalex.org/W2045107978","https://openalex.org/W2047410473","https://openalex.org/W2057692472","https://openalex.org/W2058206198","https://openalex.org/W2059428626","https://openalex.org/W2067174909","https://openalex.org/W2070885633","https://openalex.org/W2071500926","https://openalex.org/W2071794983","https://openalex.org/W2072456220","https://openalex.org/W2072683434","https://openalex.org/W2075154176","https://openalex.org/W2075904639","https://openalex.org/W2079439789","https://openalex.org/W2079620307","https://openalex.org/W2083116013","https://openalex.org/W2083164919","https://openalex.org/W2086573998","https://openalex.org/W2089827156","https://openalex.org/W2096950509","https://openalex.org/W2098587560","https://openalex.org/W2105668062","https://openalex.org/W2106140689","https://openalex.org/W2109508364","https://openalex.org/W2121880361","https://openalex.org/W2123994952","https://openalex.org/W2131473290","https://openalex.org/W2132334410","https://openalex.org/W2132437319","https://openalex.org/W2133824400","https://openalex.org/W2138778824","https://openalex.org/W2139901651","https://openalex.org/W2142613992","https://openalex.org/W2145819332","https://openalex.org/W2147993766","https://openalex.org/W2154320306","https://openalex.org/W2161605421","https://openalex.org/W2162103271","https://openalex.org/W2165216233","https://openalex.org/W2327533467"],"related_works":["https://openalex.org/W3013563583","https://openalex.org/W1982887112","https://openalex.org/W2961815824","https://openalex.org/W2180089959","https://openalex.org/W3011061596","https://openalex.org/W2321063763","https://openalex.org/W2150814991","https://openalex.org/W2395541711","https://openalex.org/W2029323837","https://openalex.org/W2027911638"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}