{"id":"https://openalex.org/W1994407817","doi":"https://doi.org/10.1007/s10822-014-9756-9","title":"Molecular insight of isotypes specific \u03b2-tubulin interaction of tubulin heterodimer with noscapinoids","display_name":"Molecular insight of isotypes specific \u03b2-tubulin interaction of tubulin heterodimer with noscapinoids","publication_year":2014,"publication_date":"2014-06-10","ids":{"openalex":"https://openalex.org/W1994407817","doi":"https://doi.org/10.1007/s10822-014-9756-9","mag":"1994407817","pmid":"https://pubmed.ncbi.nlm.nih.gov/24916062"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-014-9756-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-014-9756-9","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081162395","display_name":"Seneha Santoshi","orcid":"https://orcid.org/0000-0001-8893-2221"},"institutions":[{"id":"https://openalex.org/I153954893","display_name":"Jaypee University of Information Technology","ror":"https://ror.org/00hshrf16","country_code":"IN","type":"education","lineage":["https://openalex.org/I153954893"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Seneha Santoshi","raw_affiliation_strings":["Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Distt., Solan, 173 234, Himachal Pradesh, India","Jaypee University of Information Technology"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Distt., Solan, 173 234, Himachal Pradesh, India","institution_ids":["https://openalex.org/I153954893"]},{"raw_affiliation_string":"Jaypee University of Information Technology","institution_ids":["https://openalex.org/I153954893"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109213331","display_name":"Pradeep Kumar Naik","orcid":null},"institutions":[{"id":"https://openalex.org/I26285277","display_name":"Guru Ghasidas Vishwavidyalaya","ror":"https://ror.org/05bvxq496","country_code":"IN","type":"education","lineage":["https://openalex.org/I26285277"]},{"id":"https://openalex.org/I153954893","display_name":"Jaypee University of Information Technology","ror":"https://ror.org/00hshrf16","country_code":"IN","type":"education","lineage":["https://openalex.org/I153954893"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Pradeep K. Naik","raw_affiliation_strings":["Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Distt., Solan, 173 234, Himachal Pradesh, India","Jaypee University of Information Technology","Guru Ghasidas Vishwavidyalaya (A Central University)"],"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Distt., Solan, 173 234, Himachal Pradesh, India","institution_ids":["https://openalex.org/I153954893"]},{"raw_affiliation_string":"Jaypee University of Information Technology","institution_ids":["https://openalex.org/I153954893"]},{"raw_affiliation_string":"Guru Ghasidas Vishwavidyalaya (A Central University)","institution_ids":["https://openalex.org/I26285277"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081162395"],"corresponding_institution_ids":["https://openalex.org/I153954893"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":1.1373,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.76675446,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"28","issue":"7","first_page":"751","last_page":"763"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11845","display_name":"Cancer therapeutics and mechanisms","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tubulin","display_name":"Tubulin","score":0.8056389093399048},{"id":"https://openalex.org/keywords/noscapine","display_name":"Noscapine","score":0.7648741006851196},{"id":"https://openalex.org/keywords/isotype","display_name":"Isotype","score":0.6079027652740479},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4522755742073059},{"id":"https://openalex.org/keywords/colchicine","display_name":"Colchicine","score":0.4305354356765747},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.42699185013771057},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.39128804206848145},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.37344151735305786},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3316911458969116},{"id":"https://openalex.org/keywords/microtubule","display_name":"Microtubule","score":0.2996889352798462},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.2525606155395508},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17355984449386597},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.15245577692985535},{"id":"https://openalex.org/keywords/alkaloid","display_name":"Alkaloid","score":0.07659032940864563}],"concepts":[{"id":"https://openalex.org/C84425145","wikidata":"https://www.wikidata.org/wiki/Q422492","display_name":"Tubulin","level":3,"score":0.8056389093399048},{"id":"https://openalex.org/C2779200813","wikidata":"https://www.wikidata.org/wiki/Q415619","display_name":"Noscapine","level":3,"score":0.7648741006851196},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.6079027652740479},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4522755742073059},{"id":"https://openalex.org/C2776636253","wikidata":"https://www.wikidata.org/wiki/Q326224","display_name":"Colchicine","level":2,"score":0.4305354356765747},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.42699185013771057},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39128804206848145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.37344151735305786},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3316911458969116},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.2996889352798462},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2525606155395508},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17355984449386597},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.15245577692985535},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.07659032940864563},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003078","descriptor_name":"Colchicine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009665","descriptor_name":"Noscapine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014404","descriptor_name":"Tubulin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-014-9756-9","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-014-9756-9","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:24916062","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24916062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.800000011920929}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1480482305","https://openalex.org/W1483247593","https://openalex.org/W1916389172","https://openalex.org/W1965480223","https://openalex.org/W1971715537","https://openalex.org/W1971825349","https://openalex.org/W1975580333","https://openalex.org/W1981021420","https://openalex.org/W1982356449","https://openalex.org/W1982900169","https://openalex.org/W1983210070","https://openalex.org/W1985588649","https://openalex.org/W1986191025","https://openalex.org/W1988263368","https://openalex.org/W1989228404","https://openalex.org/W1993013485","https://openalex.org/W1993796513","https://openalex.org/W2002742784","https://openalex.org/W2009423060","https://openalex.org/W2011745200","https://openalex.org/W2013248804","https://openalex.org/W2014726755","https://openalex.org/W2023271753","https://openalex.org/W2028054902","https://openalex.org/W2031707470","https://openalex.org/W2035266068","https://openalex.org/W2049902088","https://openalex.org/W2056328903","https://openalex.org/W2061319991","https://openalex.org/W2064493660","https://openalex.org/W2064967022","https://openalex.org/W2067174909","https://openalex.org/W2075287713","https://openalex.org/W2079473982","https://openalex.org/W2102123085","https://openalex.org/W2102993309","https://openalex.org/W2105136507","https://openalex.org/W2106140689","https://openalex.org/W2109129712","https://openalex.org/W2113846183","https://openalex.org/W2115843648","https://openalex.org/W2122199548","https://openalex.org/W2128050586","https://openalex.org/W2128572087","https://openalex.org/W2140473755","https://openalex.org/W2144288821","https://openalex.org/W2147993766","https://openalex.org/W2149882720","https://openalex.org/W2158955922","https://openalex.org/W2165629556","https://openalex.org/W2169668454","https://openalex.org/W2311078281","https://openalex.org/W3004465863","https://openalex.org/W4292079585"],"related_works":["https://openalex.org/W2042100002","https://openalex.org/W2016286020","https://openalex.org/W1979617034","https://openalex.org/W1981717742","https://openalex.org/W4312065052","https://openalex.org/W2051154727","https://openalex.org/W1967189402","https://openalex.org/W1500557103","https://openalex.org/W2147679030","https://openalex.org/W2009941152"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}