{"id":"https://openalex.org/W2010540516","doi":"https://doi.org/10.1007/s10822-013-9666-2","title":"Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions","display_name":"Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions","publication_year":2013,"publication_date":"2013-07-01","ids":{"openalex":"https://openalex.org/W2010540516","doi":"https://doi.org/10.1007/s10822-013-9666-2","mag":"2010540516","pmid":"https://pubmed.ncbi.nlm.nih.gov/23881217"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-013-9666-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-013-9666-2","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11563/61849","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016675576","display_name":"Rafik Karaman","orcid":"https://orcid.org/0000-0001-5526-4490"},"institutions":[{"id":"https://openalex.org/I2800709001","display_name":"Jerusalem University College","ror":"https://ror.org/05xwpxc69","country_code":"IL","type":"education","lineage":["https://openalex.org/I2800709001"]},{"id":"https://openalex.org/I21215505","display_name":"Al-Quds University","ror":"https://ror.org/04hym7e04","country_code":"PS","type":"education","lineage":["https://openalex.org/I21215505"]}],"countries":["IL","PS"],"is_corresponding":true,"raw_author_name":"Rafik Karaman","raw_affiliation_strings":["Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, Jerusalem, Israel. dr_karaman@yahoo.com","Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel"],"affiliations":[{"raw_affiliation_string":"Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, Jerusalem, Israel. dr_karaman@yahoo.com","institution_ids":["https://openalex.org/I21215505"]},{"raw_affiliation_string":"Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel","institution_ids":["https://openalex.org/I2800709001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067380744","display_name":"Hiba Ghareeb","orcid":null},"institutions":[{"id":"https://openalex.org/I2800709001","display_name":"Jerusalem University College","ror":"https://ror.org/05xwpxc69","country_code":"IL","type":"education","lineage":["https://openalex.org/I2800709001"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hiba Ghareeb","raw_affiliation_strings":["Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel"],"affiliations":[{"raw_affiliation_string":"Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel","institution_ids":["https://openalex.org/I2800709001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090636597","display_name":"Khuloud K. Dajani","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khuloud Kamal Dajani","raw_affiliation_strings":["Faculty of Public Health Sciences, Al-Quds University, Box 20002, Jerusalem, Israel"],"affiliations":[{"raw_affiliation_string":"Faculty of Public Health Sciences, Al-Quds University, Box 20002, Jerusalem, Israel","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002426892","display_name":"Laura Scrano","orcid":"https://orcid.org/0000-0002-3716-2666"},"institutions":[{"id":"https://openalex.org/I20272500","display_name":"University of Basilicata","ror":"https://ror.org/03tc05689","country_code":"IT","type":"education","lineage":["https://openalex.org/I20272500"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Laura Scrano","raw_affiliation_strings":["Department of Sciences, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100, Potenza, Italy","Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100, Potenza, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Sciences, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100, Potenza, Italy","institution_ids":["https://openalex.org/I20272500"]},{"raw_affiliation_string":"Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100, Potenza, Italy","institution_ids":["https://openalex.org/I20272500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045784005","display_name":"Hussein Hallak","orcid":"https://orcid.org/0000-0002-1685-1374"},"institutions":[{"id":"https://openalex.org/I2800709001","display_name":"Jerusalem University College","ror":"https://ror.org/05xwpxc69","country_code":"IL","type":"education","lineage":["https://openalex.org/I2800709001"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Hussein Hallak","raw_affiliation_strings":["Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel"],"affiliations":[{"raw_affiliation_string":"Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel","institution_ids":["https://openalex.org/I2800709001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014530222","display_name":"Saleh Abu\u2010Lafi","orcid":"https://orcid.org/0000-0002-9069-8646"},"institutions":[{"id":"https://openalex.org/I2800709001","display_name":"Jerusalem University College","ror":"https://ror.org/05xwpxc69","country_code":"IL","type":"education","lineage":["https://openalex.org/I2800709001"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Saleh Abu-Lafi","raw_affiliation_strings":["Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel"],"affiliations":[{"raw_affiliation_string":"Bioorganic Chemistry Department, Faculty of Pharmacy, Al-Quds University, P. O. Box 20002, Jerusalem, Israel","institution_ids":["https://openalex.org/I2800709001"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018387462","display_name":"Gennaro Mecca","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gennaro Mecca","raw_affiliation_strings":["Exo Research Organization, Potenza, Italy"],"affiliations":[{"raw_affiliation_string":"Exo Research Organization, Potenza, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032241728","display_name":"Sabino Aurelio Bufo","orcid":"https://orcid.org/0000-0002-0857-2367"},"institutions":[{"id":"https://openalex.org/I20272500","display_name":"University of Basilicata","ror":"https://ror.org/03tc05689","country_code":"IT","type":"education","lineage":["https://openalex.org/I20272500"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabino A. Bufo","raw_affiliation_strings":["Department of Sciences, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100, Potenza, Italy","Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100, Potenza, Italy"],"affiliations":[{"raw_affiliation_string":"Department of Sciences, University of Basilicata, Via dell\u2019Ateneo Lucano 10, 85100, Potenza, Italy","institution_ids":["https://openalex.org/I20272500"]},{"raw_affiliation_string":"Department of Sciences, University of Basilicata, Via dell'Ateneo Lucano 10, 85100, Potenza, Italy","institution_ids":["https://openalex.org/I20272500"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5016675576"],"corresponding_institution_ids":["https://openalex.org/I21215505","https://openalex.org/I2800709001"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":2.2519,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.87583931,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"27","issue":"7","first_page":"615","last_page":"635"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9948999881744385,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12191","display_name":"Chemical Reaction Mechanisms","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.8740081787109375},{"id":"https://openalex.org/keywords/prodrug","display_name":"Prodrug","score":0.8610154390335083},{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"Tranexamic acid","score":0.7677938938140869},{"id":"https://openalex.org/keywords/amine-gas-treating","display_name":"Amine gas treating","score":0.6705319881439209},{"id":"https://openalex.org/keywords/hydrolysis","display_name":"Hydrolysis","score":0.5708185434341431},{"id":"https://openalex.org/keywords/tetrahedral-carbonyl-addition-compound","display_name":"Tetrahedral carbonyl addition compound","score":0.5278978943824768},{"id":"https://openalex.org/keywords/amide","display_name":"Amide","score":0.47162866592407227},{"id":"https://openalex.org/keywords/moiety","display_name":"Moiety","score":0.46123433113098145},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3866668939590454},{"id":"https://openalex.org/keywords/medicinal-chemistry","display_name":"Medicinal chemistry","score":0.3732105493545532},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.3169879913330078},{"id":"https://openalex.org/keywords/catalysis","display_name":"Catalysis","score":0.2855561673641205},{"id":"https://openalex.org/keywords/nucleophile","display_name":"Nucleophile","score":0.15350887179374695},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.05919766426086426}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8740081787109375},{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.8610154390335083},{"id":"https://openalex.org/C2779637338","wikidata":"https://www.wikidata.org/wiki/Q418666","display_name":"Tranexamic acid","level":3,"score":0.7677938938140869},{"id":"https://openalex.org/C131779359","wikidata":"https://www.wikidata.org/wiki/Q471875","display_name":"Amine gas treating","level":2,"score":0.6705319881439209},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5708185434341431},{"id":"https://openalex.org/C192604958","wikidata":"https://www.wikidata.org/wiki/Q7706517","display_name":"Tetrahedral carbonyl addition compound","level":4,"score":0.5278978943824768},{"id":"https://openalex.org/C2778439535","wikidata":"https://www.wikidata.org/wiki/Q188777","display_name":"Amide","level":2,"score":0.47162866592407227},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.46123433113098145},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3866668939590454},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.3732105493545532},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3169879913330078},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.2855561673641205},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.15350887179374695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.05919766426086426},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C2991743468","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Blood loss","level":2,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D014148","descriptor_name":"Tranexamic Acid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10822-013-9666-2","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-013-9666-2","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:23881217","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23881217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null},{"id":"pmh:oai:iris.unibas.it:11563/61849","is_oa":true,"landing_page_url":"http://hdl.handle.net/11563/61849","pdf_url":null,"source":{"id":"https://openalex.org/S4377196360","display_name":"CINECA IRIS Institutional Research Information System (University of Basilicata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20272500","host_organization_name":"University of Basilicata","host_organization_lineage":["https://openalex.org/I20272500"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unibas.it:11563/61849","is_oa":true,"landing_page_url":"http://hdl.handle.net/11563/61849","pdf_url":null,"source":{"id":"https://openalex.org/S4377196360","display_name":"CINECA IRIS Institutional Research Information System (University of Basilicata)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I20272500","host_organization_name":"University of Basilicata","host_organization_lineage":["https://openalex.org/I20272500"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.49000000953674316,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1022309144","https://openalex.org/W1520293967","https://openalex.org/W1829510808","https://openalex.org/W1948480439","https://openalex.org/W1967036936","https://openalex.org/W1967579508","https://openalex.org/W1969040007","https://openalex.org/W1972303763","https://openalex.org/W1973202934","https://openalex.org/W1975466927","https://openalex.org/W1980357072","https://openalex.org/W1984898529","https://openalex.org/W1986043170","https://openalex.org/W1991392423","https://openalex.org/W1993227076","https://openalex.org/W1994295315","https://openalex.org/W1994674083","https://openalex.org/W1995042715","https://openalex.org/W1995103763","https://openalex.org/W1999855268","https://openalex.org/W2003505022","https://openalex.org/W2007736036","https://openalex.org/W2012129602","https://openalex.org/W2012165618","https://openalex.org/W2016537088","https://openalex.org/W2024918945","https://openalex.org/W2025624195","https://openalex.org/W2027387711","https://openalex.org/W2027874018","https://openalex.org/W2032926123","https://openalex.org/W2032935102","https://openalex.org/W2034038424","https://openalex.org/W2038083805","https://openalex.org/W2043695677","https://openalex.org/W2044050036","https://openalex.org/W2053232998","https://openalex.org/W2055327257","https://openalex.org/W2056758348","https://openalex.org/W2057179269","https://openalex.org/W2058194503","https://openalex.org/W2064538270","https://openalex.org/W2065036976","https://openalex.org/W2076555292","https://openalex.org/W2079220677","https://openalex.org/W2079326433","https://openalex.org/W2080922473","https://openalex.org/W2085336624","https://openalex.org/W2085604639","https://openalex.org/W2087007861","https://openalex.org/W2087126377","https://openalex.org/W2088615896","https://openalex.org/W2093646532","https://openalex.org/W2094203461","https://openalex.org/W2095465279","https://openalex.org/W2102820529","https://openalex.org/W2103413146","https://openalex.org/W2104062274","https://openalex.org/W2108445433","https://openalex.org/W2111482516","https://openalex.org/W2111792984","https://openalex.org/W2113690539","https://openalex.org/W2122654894","https://openalex.org/W2131643485","https://openalex.org/W2134149462","https://openalex.org/W2135737980","https://openalex.org/W2145947854","https://openalex.org/W2146018326","https://openalex.org/W2154146486","https://openalex.org/W2160687225","https://openalex.org/W2161206101","https://openalex.org/W2162249417","https://openalex.org/W2165127297","https://openalex.org/W2312202389","https://openalex.org/W2320862607","https://openalex.org/W2321973160","https://openalex.org/W2322566075","https://openalex.org/W2949184650","https://openalex.org/W2949706422","https://openalex.org/W2951471535","https://openalex.org/W3005141061"],"related_works":["https://openalex.org/W3118036361","https://openalex.org/W2118188452","https://openalex.org/W3045868972","https://openalex.org/W2539195930","https://openalex.org/W2292123940","https://openalex.org/W4294878056","https://openalex.org/W2946783333","https://openalex.org/W2106450890","https://openalex.org/W2765221321","https://openalex.org/W2041447397"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1}],"updated_date":"2026-01-15T23:16:33.117629","created_date":"2025-10-10T00:00:00"}
