{"id":"https://openalex.org/W2070485353","doi":"https://doi.org/10.1007/s10822-013-9652-8","title":"Substrate recognition by norovirus polymerase: microsecond molecular dynamics study","display_name":"Substrate recognition by norovirus polymerase: microsecond molecular dynamics study","publication_year":2013,"publication_date":"2013-04-01","ids":{"openalex":"https://openalex.org/W2070485353","doi":"https://doi.org/10.1007/s10822-013-9652-8","mag":"2070485353","pmid":"https://pubmed.ncbi.nlm.nih.gov/23619980"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-013-9652-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-013-9652-8","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008759597","display_name":"Kamil Mal\u00e1\u010d","orcid":null},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210122644","display_name":"Czech Academy of Sciences, Institute of Physics","ror":"https://ror.org/02yhj4v17","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122644"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Kamil Mal\u00e1\u010d","raw_affiliation_strings":["Faculty of Mathematics and Physics, Institute of Physics, Charles University, Ke Karlovu 5, Prague 2, 121 16, Czech Republic","Faculty of Mathematics and Physics, Institute of Physics, Charles University, Ke Karlovu 5, Prague, 2, 121 16, Czech Republic"],"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Physics, Institute of Physics, Charles University, Ke Karlovu 5, Prague 2, 121 16, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210122644"]},{"raw_affiliation_string":"Faculty of Mathematics and Physics, Institute of Physics, Charles University, Ke Karlovu 5, Prague, 2, 121 16, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041325691","display_name":"Ivan Barv\u0131\u0301k","orcid":"https://orcid.org/0000-0002-0802-1346"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210122644","display_name":"Czech Academy of Sciences, Institute of Physics","ror":"https://ror.org/02yhj4v17","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210122644"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Ivan Barv\u00edk","raw_affiliation_strings":["Faculty of Mathematics and Physics, Institute of Physics, Charles University, Ke Karlovu 5, Prague 2, 121 16, Czech Republic","Charles University,"],"affiliations":[{"raw_affiliation_string":"Faculty of Mathematics and Physics, Institute of Physics, Charles University, Ke Karlovu 5, Prague 2, 121 16, Czech Republic","institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210122644"]},{"raw_affiliation_string":"Charles University,","institution_ids":["https://openalex.org/I21250087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008759597"],"corresponding_institution_ids":["https://openalex.org/I21250087","https://openalex.org/I4210122644"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.1732,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.54859342,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"27","issue":"4","first_page":"373","last_page":"388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9606000185012817,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14479","display_name":"Freezing and Crystallization Processes","score":0.9483000040054321,"subfield":{"id":"https://openalex.org/subfields/2211","display_name":"Mechanics of Materials"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/norovirus","display_name":"Norovirus","score":0.7925925254821777},{"id":"https://openalex.org/keywords/microsecond","display_name":"Microsecond","score":0.7524054050445557},{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.552320659160614},{"id":"https://openalex.org/keywords/polymerase","display_name":"Polymerase","score":0.5356065630912781},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.4231528043746948},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3788757622241974},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.27498728036880493},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2564763128757477},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19524726271629333},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.1723596453666687},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14254048466682434},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.118419349193573},{"id":"https://openalex.org/keywords/optics","display_name":"Optics","score":0.0760934054851532},{"id":"https://openalex.org/keywords/acoustics","display_name":"Acoustics","score":0.061273008584976196}],"concepts":[{"id":"https://openalex.org/C2778750513","wikidata":"https://www.wikidata.org/wiki/Q1142751","display_name":"Norovirus","level":3,"score":0.7925925254821777},{"id":"https://openalex.org/C34742353","wikidata":"https://www.wikidata.org/wiki/Q842015","display_name":"Microsecond","level":2,"score":0.7524054050445557},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.552320659160614},{"id":"https://openalex.org/C82381507","wikidata":"https://www.wikidata.org/wiki/Q416878","display_name":"Polymerase","level":3,"score":0.5356065630912781},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.4231528043746948},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3788757622241974},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.27498728036880493},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2564763128757477},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19524726271629333},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1723596453666687},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14254048466682434},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.118419349193573},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0760934054851532},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.061273008584976196},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003570","descriptor_name":"Cytidine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003570","descriptor_name":"Cytidine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003570","descriptor_name":"Cytidine Triphosphate","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003570","descriptor_name":"Cytidine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003570","descriptor_name":"Cytidine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003570","descriptor_name":"Cytidine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012324","descriptor_name":"RNA-Dependent RNA Polymerase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017250","descriptor_name":"Caliciviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017250","descriptor_name":"Caliciviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D017250","descriptor_name":"Caliciviridae Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029322","descriptor_name":"Norovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-013-9652-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-013-9652-8","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:23619980","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23619980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320321006","display_name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","ror":"https://ror.org/01pv73b02"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":69,"referenced_works":["https://openalex.org/W1966089805","https://openalex.org/W1967242595","https://openalex.org/W1973711348","https://openalex.org/W1976360756","https://openalex.org/W1976499671","https://openalex.org/W1977482735","https://openalex.org/W1978717578","https://openalex.org/W1990568874","https://openalex.org/W1991846280","https://openalex.org/W2003240840","https://openalex.org/W2010084968","https://openalex.org/W2012419248","https://openalex.org/W2015828831","https://openalex.org/W2015894034","https://openalex.org/W2021764197","https://openalex.org/W2027769799","https://openalex.org/W2029667189","https://openalex.org/W2030603638","https://openalex.org/W2032183039","https://openalex.org/W2033345469","https://openalex.org/W2034401884","https://openalex.org/W2038618123","https://openalex.org/W2040809566","https://openalex.org/W2044318670","https://openalex.org/W2047280630","https://openalex.org/W2055140930","https://openalex.org/W2057042405","https://openalex.org/W2058479011","https://openalex.org/W2060608792","https://openalex.org/W2066951434","https://openalex.org/W2069982778","https://openalex.org/W2078028336","https://openalex.org/W2082586732","https://openalex.org/W2085693638","https://openalex.org/W2091795018","https://openalex.org/W2093329195","https://openalex.org/W2093381148","https://openalex.org/W2095917523","https://openalex.org/W2096864415","https://openalex.org/W2102030104","https://openalex.org/W2106140689","https://openalex.org/W2110660825","https://openalex.org/W2110872379","https://openalex.org/W2115577316","https://openalex.org/W2122199548","https://openalex.org/W2124394465","https://openalex.org/W2128824543","https://openalex.org/W2128983623","https://openalex.org/W2132629607","https://openalex.org/W2133620840","https://openalex.org/W2136729627","https://openalex.org/W2140267249","https://openalex.org/W2147237488","https://openalex.org/W2150981663","https://openalex.org/W2155515400","https://openalex.org/W2156728090","https://openalex.org/W2157540025","https://openalex.org/W2159869554","https://openalex.org/W2168912424","https://openalex.org/W2170506864","https://openalex.org/W2313839046","https://openalex.org/W2314193970","https://openalex.org/W2317841013","https://openalex.org/W2319911380","https://openalex.org/W2322378280","https://openalex.org/W2330872822","https://openalex.org/W2337120805","https://openalex.org/W3037896947","https://openalex.org/W4240574896"],"related_works":["https://openalex.org/W2353498255","https://openalex.org/W2158937766","https://openalex.org/W2347463849","https://openalex.org/W2436036196","https://openalex.org/W2380870509","https://openalex.org/W4386134360","https://openalex.org/W4220674773","https://openalex.org/W2735197665","https://openalex.org/W4309135055","https://openalex.org/W2419672583"],"abstract_inverted_index":null,"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
