{"id":"https://openalex.org/W2033651148","doi":"https://doi.org/10.1007/s10822-012-9550-5","title":"Energetic basis for drug resistance of HIV-1 protease mutants against amprenavir","display_name":"Energetic basis for drug resistance of HIV-1 protease mutants against amprenavir","publication_year":2012,"publication_date":"2012-02-01","ids":{"openalex":"https://openalex.org/W2033651148","doi":"https://doi.org/10.1007/s10822-012-9550-5","mag":"2033651148","pmid":"https://pubmed.ncbi.nlm.nih.gov/22350569"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-012-9550-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-012-9550-5","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090815521","display_name":"Parimal Kar","orcid":"https://orcid.org/0000-0001-8451-9739"},"institutions":[{"id":"https://openalex.org/I4210092306","display_name":"Max Planck Institute of Colloids and Interfaces","ror":"https://ror.org/00pwgnh47","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210092306"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Parimal Kar","raw_affiliation_strings":["Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. Parimal.Kar@mpikg.mpg.de","Department of Theory & Bio-systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany. Parimal.Kar@mpikg.mpg.de","institution_ids":["https://openalex.org/I4210092306"]},{"raw_affiliation_string":"Department of Theory & Bio-systems, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany","institution_ids":["https://openalex.org/I4210092306"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087220828","display_name":"Volker Knecht","orcid":"https://orcid.org/0000-0001-6008-1744"},"institutions":[{"id":"https://openalex.org/I4210092306","display_name":"Max Planck Institute of Colloids and Interfaces","ror":"https://ror.org/00pwgnh47","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210092306"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Volker Knecht","raw_affiliation_strings":["Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Am M\u00fchlenberg 1, 14476, Potsdam, Germany","Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Am M\u00fchlenberg 1, 14476, Potsdam, Germany","institution_ids":["https://openalex.org/I4210092306"]},{"raw_affiliation_string":"Theorie & Bio-Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society","institution_ids":["https://openalex.org/I4210092306","https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090815521"],"corresponding_institution_ids":["https://openalex.org/I4210092306"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":3.0515,"has_fulltext":false,"cited_by_count":59,"citation_normalized_percentile":{"value":0.91268914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"26","issue":"2","first_page":"215","last_page":"232"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amprenavir","display_name":"Amprenavir","score":0.9685781598091125},{"id":"https://openalex.org/keywords/protonation","display_name":"Protonation","score":0.6085002422332764},{"id":"https://openalex.org/keywords/hiv-1-protease","display_name":"HIV-1 protease","score":0.5902504324913025},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5555859208106995},{"id":"https://openalex.org/keywords/protease","display_name":"Protease","score":0.5148093104362488},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5092869997024536},{"id":"https://openalex.org/keywords/affinities","display_name":"Affinities","score":0.4810045659542084},{"id":"https://openalex.org/keywords/van-der-waals-force","display_name":"van der Waals force","score":0.43770354986190796},{"id":"https://openalex.org/keywords/wild-type","display_name":"Wild type","score":0.41566768288612366},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.37251099944114685},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.18545225262641907},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.1359264850616455},{"id":"https://openalex.org/keywords/ion","display_name":"Ion","score":0.08722764253616333},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.060013651847839355}],"concepts":[{"id":"https://openalex.org/C2777363262","wikidata":"https://www.wikidata.org/wiki/Q422198","display_name":"Amprenavir","level":5,"score":0.9685781598091125},{"id":"https://openalex.org/C30095370","wikidata":"https://www.wikidata.org/wiki/Q899488","display_name":"Protonation","level":3,"score":0.6085002422332764},{"id":"https://openalex.org/C2777583353","wikidata":"https://www.wikidata.org/wiki/Q410261","display_name":"HIV-1 protease","level":4,"score":0.5902504324913025},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5555859208106995},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.5148093104362488},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5092869997024536},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.4810045659542084},{"id":"https://openalex.org/C126061179","wikidata":"https://www.wikidata.org/wiki/Q189627","display_name":"van der Waals force","level":3,"score":0.43770354986190796},{"id":"https://openalex.org/C207583985","wikidata":"https://www.wikidata.org/wiki/Q128723","display_name":"Wild type","level":4,"score":0.41566768288612366},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37251099944114685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18545225262641907},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1359264850616455},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.08722764253616333},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.060013651847839355},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000596","descriptor_name":"Amino Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002219","descriptor_name":"Carbamates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005663","descriptor_name":"Furans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017320","descriptor_name":"HIV Protease Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020134","descriptor_name":"Catalytic Domain","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1007/s10822-012-9550-5","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-012-9550-5","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:22350569","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22350569","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null},{"id":"pmh:oai:edoc.mpg.de:609736","is_oa":false,"landing_page_url":"http://edoc.mpg.de/609736","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Computer-Aided Molecular Design, v.26, 215-232 (2012)","raw_type":"Article"},{"id":"pmh:oai:escidoc.org:escidoc:1924557","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0015-4452-9","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6399999856948853,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1496518737","https://openalex.org/W1579594936","https://openalex.org/W1593098626","https://openalex.org/W1793492141","https://openalex.org/W1963775782","https://openalex.org/W1966720984","https://openalex.org/W1968334638","https://openalex.org/W1968484323","https://openalex.org/W1969405013","https://openalex.org/W1975580333","https://openalex.org/W1976499671","https://openalex.org/W1978482484","https://openalex.org/W1984157110","https://openalex.org/W1984197256","https://openalex.org/W1984738107","https://openalex.org/W1985183069","https://openalex.org/W1988562891","https://openalex.org/W1994821580","https://openalex.org/W1998645872","https://openalex.org/W2014772558","https://openalex.org/W2015688756","https://openalex.org/W2019526592","https://openalex.org/W2022973223","https://openalex.org/W2023563495","https://openalex.org/W2025288556","https://openalex.org/W2037535298","https://openalex.org/W2043101472","https://openalex.org/W2043120072","https://openalex.org/W2043429268","https://openalex.org/W2043644039","https://openalex.org/W2044646154","https://openalex.org/W2045052213","https://openalex.org/W2046102151","https://openalex.org/W2046439270","https://openalex.org/W2048719253","https://openalex.org/W2054788798","https://openalex.org/W2058521024","https://openalex.org/W2059579908","https://openalex.org/W2065631521","https://openalex.org/W2065838297","https://openalex.org/W2067174909","https://openalex.org/W2073023478","https://openalex.org/W2075369230","https://openalex.org/W2076790509","https://openalex.org/W2080237955","https://openalex.org/W2080674340","https://openalex.org/W2083905373","https://openalex.org/W2092443343","https://openalex.org/W2092640972","https://openalex.org/W2095398138","https://openalex.org/W2101837956","https://openalex.org/W2102174621","https://openalex.org/W2103631613","https://openalex.org/W2104270610","https://openalex.org/W2105103540","https://openalex.org/W2106140689","https://openalex.org/W2106448315","https://openalex.org/W2118233996","https://openalex.org/W2120338717","https://openalex.org/W2123734473","https://openalex.org/W2143857558","https://openalex.org/W2144288821","https://openalex.org/W2144775933","https://openalex.org/W2147993766","https://openalex.org/W2152997175","https://openalex.org/W2161531618","https://openalex.org/W2414698896","https://openalex.org/W4211079109","https://openalex.org/W4236479494","https://openalex.org/W4302592293"],"related_works":["https://openalex.org/W2071527401","https://openalex.org/W2967653239","https://openalex.org/W2161234507","https://openalex.org/W2117927779","https://openalex.org/W2527992957","https://openalex.org/W2042538674","https://openalex.org/W1648971203","https://openalex.org/W2294882517","https://openalex.org/W4205087713","https://openalex.org/W2014349456"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}