{"id":"https://openalex.org/W2132010529","doi":"https://doi.org/10.1007/s10822-005-9015-1","title":"ENPDA: an evolutionary structure-based de novo peptide design algorithm","display_name":"ENPDA: an evolutionary structure-based de novo peptide design algorithm","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W2132010529","doi":"https://doi.org/10.1007/s10822-005-9015-1","mag":"2132010529","pmid":"https://pubmed.ncbi.nlm.nih.gov/16267689"},"language":"en","primary_location":{"id":"doi:10.1007/s10822-005-9015-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-005-9015-1","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080970584","display_name":"Ignasi Belda","orcid":"https://orcid.org/0000-0001-7527-0652"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ignasi Belda","raw_affiliation_strings":["Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016182320","display_name":"Sergio Madurga","orcid":"https://orcid.org/0000-0002-8135-7057"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sergio Madurga","raw_affiliation_strings":["Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036640710","display_name":"Xavier Llor\u00e0","orcid":null},"institutions":[{"id":"https://openalex.org/I157725225","display_name":"University of Illinois Urbana-Champaign","ror":"https://ror.org/047426m28","country_code":"US","type":"education","lineage":["https://openalex.org/I157725225"]},{"id":"https://openalex.org/I4210135837","display_name":"National Center for Supercomputing Applications","ror":"https://ror.org/03r10zj06","country_code":"US","type":"facility","lineage":["https://openalex.org/I157725225","https://openalex.org/I4210135837"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xavier Llor\u00e0","raw_affiliation_strings":["Illinois Genetic Algorithms Laboratory, National Center for Supercomputing Applications, University of Illinois at Urbana\u2013Champaign, Illinois, USA","Illinois Genetic Algorithms Laboratory, National Center for Supercomputing Applications, University of Illinois at Urbana\u2013Champaign, 117 Transportation Building, 104 South Mathews Urbana, Illinois, IL, 61801-2996, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Illinois Genetic Algorithms Laboratory, National Center for Supercomputing Applications, University of Illinois at Urbana\u2013Champaign, Illinois, USA","institution_ids":["https://openalex.org/I4210135837"]},{"raw_affiliation_string":"Illinois Genetic Algorithms Laboratory, National Center for Supercomputing Applications, University of Illinois at Urbana\u2013Champaign, 117 Transportation Building, 104 South Mathews Urbana, Illinois, IL, 61801-2996, USA","institution_ids":["https://openalex.org/I157725225","https://openalex.org/I4210135837"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086993070","display_name":"Marc Martinell","orcid":"https://orcid.org/0000-0002-2462-2643"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marc Martinell","raw_affiliation_strings":["Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087795214","display_name":"Teresa Tarrag\u00f3","orcid":null},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Teresa Tarrag\u00f3","raw_affiliation_strings":["Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Josep Samitier, 1-5, Barcelona, E 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047650636","display_name":"Mireia Piqueras","orcid":null},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mireia G. Piqueras","raw_affiliation_strings":["Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Barcelona, Spain","Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s, 1-11, Barcelona, E 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s, 1-11, Barcelona, E 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070367315","display_name":"Ernesto Nicol\u00e1s","orcid":"https://orcid.org/0000-0002-5943-5450"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ernesto Nicol\u00e1s","raw_affiliation_strings":["Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Barcelona, Spain","Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s, 1-11, Barcelona, E 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s, 1-11, Barcelona, E 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037246000","display_name":"Ernest Giralt","orcid":"https://orcid.org/0000-0001-8381-1797"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ernest Giralt","raw_affiliation_strings":["Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Barcelona, Spain","Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s, 1-11, Barcelona, E 08028, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Institut de Recerca Biom\u00e8dica de Barcelona, Parc Cient\u00edfic de Barcelona, Universitat de Barcelona, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"Departament de Qu\u00edmica Org\u00e0nica, Universitat de Barcelona, Mart\u00ed i Franqu\u00e8s, 1-11, Barcelona, E 08028, Spain","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5037246000"],"corresponding_institution_ids":["https://openalex.org/I71999127"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":1.6537,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.83718498,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"19","issue":"8","first_page":"585","last_page":"601"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5298718214035034},{"id":"https://openalex.org/keywords/protein-design","display_name":"Protein design","score":0.5198215246200562},{"id":"https://openalex.org/keywords/heuristics","display_name":"Heuristics","score":0.4938066899776459},{"id":"https://openalex.org/keywords/structural-bioinformatics","display_name":"Structural bioinformatics","score":0.44839489459991455},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4313090741634369},{"id":"https://openalex.org/keywords/evolutionary-algorithm","display_name":"Evolutionary algorithm","score":0.4259575605392456},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2588386833667755},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.23778274655342102},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.22404319047927856},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20607927441596985},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15416261553764343}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5298718214035034},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.5198215246200562},{"id":"https://openalex.org/C127705205","wikidata":"https://www.wikidata.org/wiki/Q5748245","display_name":"Heuristics","level":2,"score":0.4938066899776459},{"id":"https://openalex.org/C69131567","wikidata":"https://www.wikidata.org/wiki/Q2068215","display_name":"Structural bioinformatics","level":3,"score":0.44839489459991455},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4313090741634369},{"id":"https://openalex.org/C159149176","wikidata":"https://www.wikidata.org/wiki/Q14489129","display_name":"Evolutionary algorithm","level":2,"score":0.4259575605392456},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2588386833667755},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.23778274655342102},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.22404319047927856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20607927441596985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15416261553764343},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000085822","descriptor_name":"Prolyl Oligopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085822","descriptor_name":"Prolyl Oligopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000085822","descriptor_name":"Prolyl Oligopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006183","descriptor_name":"H-2 Antigens","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D027081","descriptor_name":"DNA Gyrase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10822-005-9015-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10822-005-9015-1","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:16267689","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16267689","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8799999952316284,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W63064086","https://openalex.org/W119114865","https://openalex.org/W139976806","https://openalex.org/W163590980","https://openalex.org/W261298141","https://openalex.org/W584914605","https://openalex.org/W586395054","https://openalex.org/W952838121","https://openalex.org/W1495033819","https://openalex.org/W1497256448","https://openalex.org/W1505394602","https://openalex.org/W1508312673","https://openalex.org/W1542067597","https://openalex.org/W1549148204","https://openalex.org/W1559956479","https://openalex.org/W1562424368","https://openalex.org/W1564267908","https://openalex.org/W1574396325","https://openalex.org/W1576818901","https://openalex.org/W1588177623","https://openalex.org/W1592238003","https://openalex.org/W1650797637","https://openalex.org/W1764151989","https://openalex.org/W1967224365","https://openalex.org/W1967747511","https://openalex.org/W1971302107","https://openalex.org/W1973098530","https://openalex.org/W1981425874","https://openalex.org/W1986176168","https://openalex.org/W1989448721","https://openalex.org/W1994859764","https://openalex.org/W1996713229","https://openalex.org/W1996793152","https://openalex.org/W1999489135","https://openalex.org/W2003050682","https://openalex.org/W2009644767","https://openalex.org/W2011230643","https://openalex.org/W2022885801","https://openalex.org/W2026178423","https://openalex.org/W2046564413","https://openalex.org/W2051137721","https://openalex.org/W2052067496","https://openalex.org/W2058369753","https://openalex.org/W2061658069","https://openalex.org/W2072632083","https://openalex.org/W2091901336","https://openalex.org/W2094148990","https://openalex.org/W2097233276","https://openalex.org/W2101312482","https://openalex.org/W2102248717","https://openalex.org/W2118612667","https://openalex.org/W2130479394","https://openalex.org/W2142183404","https://openalex.org/W2145325544","https://openalex.org/W2152292155","https://openalex.org/W2158534713","https://openalex.org/W2159027901","https://openalex.org/W2159080219","https://openalex.org/W2170711396","https://openalex.org/W2329792474","https://openalex.org/W2411455738","https://openalex.org/W2415580803","https://openalex.org/W3020913839","https://openalex.org/W4213177353","https://openalex.org/W4242306912","https://openalex.org/W4250444145","https://openalex.org/W6793806228"],"related_works":["https://openalex.org/W2952785685","https://openalex.org/W2904811114","https://openalex.org/W1988730649","https://openalex.org/W2607853144","https://openalex.org/W2092087990","https://openalex.org/W1995668710","https://openalex.org/W2061685714","https://openalex.org/W2048936194","https://openalex.org/W4290600387","https://openalex.org/W3210595847"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-07-29T09:40:50.615796","created_date":"2025-10-10T00:00:00"}
