{"id":"https://openalex.org/W4401643415","doi":"https://doi.org/10.1007/s10489-024-05625-5","title":"Multi-functional scar tissue discrimination platform construction and exploration of molecular mechanism for scar formation","display_name":"Multi-functional scar tissue discrimination platform construction and exploration of molecular mechanism for scar formation","publication_year":2024,"publication_date":"2024-08-16","ids":{"openalex":"https://openalex.org/W4401643415","doi":"https://doi.org/10.1007/s10489-024-05625-5"},"language":"en","primary_location":{"id":"doi:10.1007/s10489-024-05625-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10489-024-05625-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10489-024-05625-5.pdf","source":{"id":"https://openalex.org/S74726891","display_name":"Applied Intelligence","issn_l":"0924-669X","issn":["0924-669X","1573-7497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10489-024-05625-5.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051454075","display_name":"X. Hu","orcid":"https://orcid.org/0009-0003-4374-0551"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]},{"id":"https://openalex.org/I96733725","display_name":"Shanghai Maritime University","ror":"https://ror.org/04z7qrj66","country_code":"CN","type":"education","lineage":["https://openalex.org/I96733725"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoqian Hu","raw_affiliation_strings":["College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave, Shanghai, 201306, P. R. China","Department of Orthopedic Surgery, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0009-0003-4374-0551","affiliations":[{"raw_affiliation_string":"College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave, Shanghai, 201306, P. R. China","institution_ids":["https://openalex.org/I96733725"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078785531","display_name":"Yaling Yu","orcid":"https://orcid.org/0000-0001-6116-4330"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaling Yu","raw_affiliation_strings":["Department of Orthopedic Surgery, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","Institute of Microsurgery on Extremities, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0000-0001-6116-4330","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Institute of Microsurgery on Extremities, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001837630","display_name":"Wei Kong","orcid":"https://orcid.org/0000-0002-6554-4338"},"institutions":[{"id":"https://openalex.org/I96733725","display_name":"Shanghai Maritime University","ror":"https://ror.org/04z7qrj66","country_code":"CN","type":"education","lineage":["https://openalex.org/I96733725"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Kong","raw_affiliation_strings":["College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave, Shanghai, 201306, P. R. China"],"raw_orcid":"https://orcid.org/0000-0002-6554-4338","affiliations":[{"raw_affiliation_string":"College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave, Shanghai, 201306, P. R. China","institution_ids":["https://openalex.org/I96733725"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068687838","display_name":"Shuaiqun Wang","orcid":"https://orcid.org/0000-0001-6274-4097"},"institutions":[{"id":"https://openalex.org/I96733725","display_name":"Shanghai Maritime University","ror":"https://ror.org/04z7qrj66","country_code":"CN","type":"education","lineage":["https://openalex.org/I96733725"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shuaiqun Wang","raw_affiliation_strings":["College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave, Shanghai, 201306, P. R. China"],"raw_orcid":"https://orcid.org/0000-0001-6274-4097","affiliations":[{"raw_affiliation_string":"College of Information Engineering, Shanghai Maritime University, 1550 Haigang Ave, Shanghai, 201306, P. R. China","institution_ids":["https://openalex.org/I96733725"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101672764","display_name":"Gen Wen","orcid":"https://orcid.org/0000-0001-6477-4740"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gen Wen","raw_affiliation_strings":["Department of Orthopedic Surgery, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China"],"raw_orcid":"https://orcid.org/0000-0001-6477-4740","affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery, Shanghai Sixth People\u2019s Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I4210144482"]},{"raw_affiliation_string":"Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200233, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5001837630","https://openalex.org/A5101672764"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482","https://openalex.org/I96733725"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":0.8431,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.75726917,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":96},"biblio":{"volume":"54","issue":"22","first_page":"11295","last_page":"11310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9501000046730042,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9501000046730042,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9451000094413757,"subfield":{"id":"https://openalex.org/subfields/2742","display_name":"Rehabilitation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.819893479347229},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.7318897247314453},{"id":"https://openalex.org/keywords/scar-tissue","display_name":"Scar tissue","score":0.5847475528717041},{"id":"https://openalex.org/keywords/surgery","display_name":"Surgery","score":0.11077684164047241},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.09092795848846436}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.819893479347229},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7318897247314453},{"id":"https://openalex.org/C3018954641","wikidata":"https://www.wikidata.org/wiki/Q7430223","display_name":"Scar tissue","level":2,"score":0.5847475528717041},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11077684164047241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.09092795848846436},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s10489-024-05625-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10489-024-05625-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10489-024-05625-5.pdf","source":{"id":"https://openalex.org/S74726891","display_name":"Applied Intelligence","issn_l":"0924-669X","issn":["0924-669X","1573-7497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Intelligence","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s10489-024-05625-5","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10489-024-05625-5","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10489-024-05625-5.pdf","source":{"id":"https://openalex.org/S74726891","display_name":"Applied Intelligence","issn_l":"0924-669X","issn":["0924-669X","1573-7497"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied Intelligence","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","score":0.4099999964237213,"display_name":"Reduced inequalities"},{"id":"https://metadata.un.org/sdg/5","score":0.4000000059604645,"display_name":"Gender equality"}],"awards":[{"id":"https://openalex.org/G5879935106","display_name":null,"funder_award_id":"18ZR1417200","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"},{"id":"https://openalex.org/G6491047327","display_name":null,"funder_award_id":"No. 18ZR1417200","funder_id":"https://openalex.org/F4320309612","funder_display_name":"Natural Science Foundation of Shanghai"}],"funders":[{"id":"https://openalex.org/F4320309612","display_name":"Natural Science Foundation of Shanghai","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4401643415.pdf","grobid_xml":"https://content.openalex.org/works/W4401643415.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1902027874","https://openalex.org/W2154797625","https://openalex.org/W2943993363","https://openalex.org/W2972588473","https://openalex.org/W2985289210","https://openalex.org/W2990745855","https://openalex.org/W2995312601","https://openalex.org/W3006951656","https://openalex.org/W3156922928","https://openalex.org/W3185000423","https://openalex.org/W3202226602","https://openalex.org/W4210327192","https://openalex.org/W4229032448","https://openalex.org/W4280589656","https://openalex.org/W4298137411","https://openalex.org/W4318476344","https://openalex.org/W4328049425","https://openalex.org/W4366760820","https://openalex.org/W4378982643","https://openalex.org/W4386078698","https://openalex.org/W4390399270","https://openalex.org/W4391222591"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W4396696052","https://openalex.org/W2382997850","https://openalex.org/W2382290278"],"abstract_inverted_index":{"Scars":[0],"that":[1,111],"form":[2],"after":[3],"skin":[4,11,63],"injury":[5],"can":[6,33],"cause":[7],"structural":[8],"and":[9,23,25,49,53,72,90,98,104,167,196,217,236,240,249,259],"functional":[10],"damage.":[12],"Currently,":[13],"scar":[14,47,64,185,257],"tissue":[15,48],"determination":[16],"relies":[17],"mainly":[18],"on":[19,68,131],"doctors\u2019":[20],"subjective":[21],"observations":[22],"judgments":[24],"lacks":[26],"objectivity.":[27],"However,":[28],"current":[29],"deep":[30,70,164],"learning":[31,71],"models":[32],"only":[34],"achieve":[35],"specific":[36],"discrimination":[37,127,150,154,174],"using":[38,84],"unimodal":[39,103],"data,":[40],"which":[41,251],"limits":[42],"the":[43,112,125,147,161,182,190,209,226,229],"comprehensive":[44],"understanding":[45],"of":[46,119,156,163,184],"may":[50],"reduce":[51],"accuracy":[52,118,155],"stability.":[54],"To":[55],"solve":[56],"these":[57],"problems,":[58],"in":[59],"this":[60,177,222],"study,":[61,223],"a":[62,73,85,91,116,132,153,187],"recognition":[65],"platform":[66,114],"based":[67],"advanced":[69],"weighted":[74],"aggregation":[75],"network":[76],"fusion":[77,170],"method":[78,188],"is":[79,82,99],"proposed.":[80],"It":[81],"implemented":[83],"residual":[86],"network-based":[87],"CNN":[88],"model":[89,94,128,151],"logistic":[92],"regression":[93],"with":[95,189],"L1":[96],"regularization":[97],"suitable":[100],"for":[101,121,172,255],"both":[102],"multimodal":[105,149,168],"data.":[106,220],"The":[107],"experimental":[108],"results":[109,159],"showed":[110],"proposed":[113,148],"achieved":[115,152],"satisfactory":[117],"98.26%":[120],"image":[122,173,215],"discrimination.":[123],"In":[124,145,221],"gene":[126,137,218],"test":[129,133],"performed":[130],"dataset":[134],"containing":[135],"17":[136],"expression":[138,219],"samples,":[139],"all":[140],"samples":[141],"were":[142],"accurately":[143],"discriminated.":[144],"addition,":[146],"98.23%.":[157],"These":[158],"validate":[160],"effectiveness":[162],"feature":[165,169],"extraction":[166],"techniques":[171],"tasks.":[175],"On":[176],"basis,":[178],"to":[179,192,207],"deeply":[180],"explore":[181,208],"pathogenesis":[183],"formation,":[186],"ability":[191],"integrate":[193],"regularization,":[194],"sparsity,":[195],"orthogonality":[197],"constraints,":[198],"multiconstraint":[199],"joint":[200],"non-negative":[201],"matrix":[202],"factorization":[203],"(MCJNMF),":[204],"was":[205],"used":[206],"genetic":[210],"correlation":[211],"between":[212,228],"collagen":[213,237],"micrographic":[214],"features":[216],"we":[224],"confirmed":[225],"association":[227],"calcium":[230],"signaling":[231,234],"pathway,":[232,235],"MAPK":[233],"fiber":[238],"repair,":[239],"successfully":[241],"identified":[242],"11":[243],"potential":[244],"therapeutic":[245],"targets,":[246],"including":[247],"TRIM59":[248],"TBC1D9,":[250],"provide":[252],"important":[253],"clues":[254],"future":[256],"treatment":[258],"prevention":[260],"strategies.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":2}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
