{"id":"https://openalex.org/W2027561030","doi":"https://doi.org/10.1007/s10339-010-0375-7","title":"Insufficient augmentation of ambient GABA responsible for age-related cognitive deficit","display_name":"Insufficient augmentation of ambient GABA responsible for age-related cognitive deficit","publication_year":2010,"publication_date":"2010-11-02","ids":{"openalex":"https://openalex.org/W2027561030","doi":"https://doi.org/10.1007/s10339-010-0375-7","mag":"2027561030","pmid":"https://pubmed.ncbi.nlm.nih.gov/21046192"},"language":"en","primary_location":{"id":"doi:10.1007/s10339-010-0375-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10339-010-0375-7","pdf_url":null,"source":{"id":"https://openalex.org/S99753134","display_name":"Cognitive Processing","issn_l":"1612-4782","issn":["1612-4782","1612-4790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cognitive Processing","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021169740","display_name":"Hideyuki Fujiwara","orcid":null},"institutions":[{"id":"https://openalex.org/I6178835","display_name":"Ibaraki University","ror":"https://ror.org/00sjd5653","country_code":"JP","type":"education","lineage":["https://openalex.org/I6178835"]},{"id":"https://openalex.org/I65143321","display_name":"Hitachi (Japan)","ror":"https://ror.org/02exqgm79","country_code":"JP","type":"company","lineage":["https://openalex.org/I65143321"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Hideyuki Fujiwara","raw_affiliation_strings":["Department of Intelligent Systems Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibaraki 316-8511, Japan","Ibaraki University"],"affiliations":[{"raw_affiliation_string":"Department of Intelligent Systems Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibaraki 316-8511, Japan","institution_ids":["https://openalex.org/I6178835","https://openalex.org/I65143321"]},{"raw_affiliation_string":"Ibaraki University","institution_ids":["https://openalex.org/I6178835"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109139415","display_name":"MeiHong Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meihong Zheng","raw_affiliation_strings":["Department of Psychology, Tsinghua University, Haidian District, Beijing, 100084, China","Tsinghua University"],"affiliations":[{"raw_affiliation_string":"Department of Psychology, Tsinghua University, Haidian District, Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Tsinghua University","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051024661","display_name":"Ai Miyamoto","orcid":"https://orcid.org/0000-0003-4644-4312"},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Ai Miyamoto","raw_affiliation_strings":["Department of Psychology, University of Victoria, Victoria, BC, Canada","University of Victoria"],"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Victoria, Victoria, BC, Canada","institution_ids":["https://openalex.org/I212119943"]},{"raw_affiliation_string":"University of Victoria","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073667862","display_name":"Osamu Hoshino","orcid":null},"institutions":[{"id":"https://openalex.org/I6178835","display_name":"Ibaraki University","ror":"https://ror.org/00sjd5653","country_code":"JP","type":"education","lineage":["https://openalex.org/I6178835"]},{"id":"https://openalex.org/I65143321","display_name":"Hitachi (Japan)","ror":"https://ror.org/02exqgm79","country_code":"JP","type":"company","lineage":["https://openalex.org/I65143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Osamu Hoshino","raw_affiliation_strings":["Department of Intelligent Systems Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibaraki, 316-8511, Japan","Ibaraki University"],"affiliations":[{"raw_affiliation_string":"Department of Intelligent Systems Engineering, Ibaraki University, 4-12-1 Nakanarusawa, Hitachi, Ibaraki, 316-8511, Japan","institution_ids":["https://openalex.org/I6178835","https://openalex.org/I65143321"]},{"raw_affiliation_string":"Ibaraki University","institution_ids":["https://openalex.org/I6178835"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021169740"],"corresponding_institution_ids":["https://openalex.org/I6178835","https://openalex.org/I65143321"],"apc_list":{"value":2690,"currency":"EUR","value_usd":3390},"apc_paid":null,"fwci":0.3522,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53088188,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"12","issue":"2","first_page":"151","last_page":"159"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/inhibitory-postsynaptic-potential","display_name":"Inhibitory postsynaptic potential","score":0.6293208599090576},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6246594190597534},{"id":"https://openalex.org/keywords/stimulus","display_name":"Stimulus (psychology)","score":0.5905723571777344},{"id":"https://openalex.org/keywords/transporter","display_name":"Transporter","score":0.5553815364837646},{"id":"https://openalex.org/keywords/premovement-neuronal-activity","display_name":"Premovement neuronal activity","score":0.470714271068573},{"id":"https://openalex.org/keywords/extracellular","display_name":"Extracellular","score":0.46679574251174927},{"id":"https://openalex.org/keywords/basal","display_name":"Basal (medicine)","score":0.45077913999557495},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.4375843405723572},{"id":"https://openalex.org/keywords/gamma-aminobutyric-acid","display_name":"gamma-Aminobutyric acid","score":0.4116394817829132},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.33204808831214905},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31249234080314636},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2936730682849884},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.14853525161743164},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.08732679486274719}],"concepts":[{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.6293208599090576},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6246594190597534},{"id":"https://openalex.org/C2779918689","wikidata":"https://www.wikidata.org/wiki/Q3771842","display_name":"Stimulus (psychology)","level":2,"score":0.5905723571777344},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.5553815364837646},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.470714271068573},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46679574251174927},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.45077913999557495},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4375843405723572},{"id":"https://openalex.org/C2777771985","wikidata":"https://www.wikidata.org/wiki/Q210021","display_name":"gamma-Aminobutyric acid","level":3,"score":0.4116394817829132},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.33204808831214905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31249234080314636},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2936730682849884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14853525161743164},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08732679486274719},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005680","descriptor_name":"gamma-Aminobutyric Acid","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009433","descriptor_name":"Neural Inhibition","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050485","descriptor_name":"GABA Plasma Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10339-010-0375-7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10339-010-0375-7","pdf_url":null,"source":{"id":"https://openalex.org/S99753134","display_name":"Cognitive Processing","issn_l":"1612-4782","issn":["1612-4782","1612-4790"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cognitive Processing","raw_type":"journal-article"},{"id":"pmid:21046192","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21046192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cognitive processing","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1483276925","https://openalex.org/W1543041220","https://openalex.org/W1545211126","https://openalex.org/W1937675039","https://openalex.org/W1964776414","https://openalex.org/W1966692769","https://openalex.org/W1977265431","https://openalex.org/W1984212133","https://openalex.org/W1992713633","https://openalex.org/W1994561581","https://openalex.org/W2000516728","https://openalex.org/W2006842487","https://openalex.org/W2007219297","https://openalex.org/W2013045879","https://openalex.org/W2018118045","https://openalex.org/W2023781008","https://openalex.org/W2025114609","https://openalex.org/W2025603247","https://openalex.org/W2029215893","https://openalex.org/W2039752037","https://openalex.org/W2041220317","https://openalex.org/W2061769920","https://openalex.org/W2065154130","https://openalex.org/W2072472879","https://openalex.org/W2080218996","https://openalex.org/W2081052063","https://openalex.org/W2087356150","https://openalex.org/W2094850964","https://openalex.org/W2104291446","https://openalex.org/W2114492421","https://openalex.org/W2135382901","https://openalex.org/W2144841925","https://openalex.org/W2149242603","https://openalex.org/W2149439254","https://openalex.org/W2149451815","https://openalex.org/W2168467995","https://openalex.org/W4243115481","https://openalex.org/W4293254491","https://openalex.org/W4388325361"],"related_works":["https://openalex.org/W2108588741","https://openalex.org/W2073508040","https://openalex.org/W3159614036","https://openalex.org/W2737944388","https://openalex.org/W2432552858","https://openalex.org/W3164714412","https://openalex.org/W4212915683","https://openalex.org/W2895989784","https://openalex.org/W2149996614","https://openalex.org/W2980943964"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}