{"id":"https://openalex.org/W3021843318","doi":"https://doi.org/10.1007/s10278-020-00341-1","title":"Tumor Segmentation and Feature Extraction from Whole-Body FDG-PET/CT Using Cascaded 2D and 3D Convolutional Neural Networks","display_name":"Tumor Segmentation and Feature Extraction from Whole-Body FDG-PET/CT Using Cascaded 2D and 3D Convolutional Neural Networks","publication_year":2020,"publication_date":"2020-05-06","ids":{"openalex":"https://openalex.org/W3021843318","doi":"https://doi.org/10.1007/s10278-020-00341-1","mag":"3021843318","pmid":"https://pubmed.ncbi.nlm.nih.gov/32378059"},"language":"en","primary_location":{"id":"doi:10.1007/s10278-020-00341-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10278-020-00341-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10278-020-00341-1.pdf","source":{"id":"https://openalex.org/S62275304","display_name":"Journal of Digital Imaging","issn_l":"0897-1889","issn":["0897-1889","1618-727X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Digital Imaging","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10278-020-00341-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078885080","display_name":"Skander Jemaa","orcid":"https://orcid.org/0009-0009-3627-7670"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Skander Jemaa","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA. jemaam@gene.com","Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA. jemaam@gene.com","institution_ids":[]},{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044122805","display_name":"Jill Fredrickson","orcid":"https://orcid.org/0000-0002-2693-4309"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jill Fredrickson","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062841169","display_name":"Richard A.D. Carano","orcid":"https://orcid.org/0000-0002-6799-4367"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A. D. Carano","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112481640","display_name":"Tina Nielsen","orcid":null},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"Roche (Switzerland)","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tina Nielsen","raw_affiliation_strings":["F. Hoffman-La Roche Ltd., Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffman-La Roche Ltd., Basel, Switzerland","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070321113","display_name":"Alex de Crespigny","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alex de Crespigny","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091515666","display_name":"Thomas Bengtsson","orcid":"https://orcid.org/0000-0002-9667-8873"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Bengtsson","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5078885080"],"corresponding_institution_ids":[],"apc_list":{"value":3190,"currency":"EUR","value_usd":4190},"apc_paid":{"value":3190,"currency":"EUR","value_usd":4190},"fwci":5.6888,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.97081413,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"33","issue":"4","first_page":"888","last_page":"894"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.6589095592498779},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6180282831192017},{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.5537885427474976},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5405700206756592},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5253336429595947},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.4834664463996887},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4365254044532776},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3758384585380554},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36733922362327576},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14232301712036133}],"concepts":[{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.6589095592498779},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6180282831192017},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.5537885427474976},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5405700206756592},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5253336429595947},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.4834664463996887},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4365254044532776},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3758384585380554},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36733922362327576},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14232301712036133}],"mesh":[{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072078","descriptor_name":"Positron Emission Tomography Computed Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/s10278-020-00341-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10278-020-00341-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10278-020-00341-1.pdf","source":{"id":"https://openalex.org/S62275304","display_name":"Journal of Digital Imaging","issn_l":"0897-1889","issn":["0897-1889","1618-727X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Digital Imaging","raw_type":"journal-article"},{"id":"pmid:32378059","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32378059","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of digital imaging","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:7522127","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7522127","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Digit Imaging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/s10278-020-00341-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10278-020-00341-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10278-020-00341-1.pdf","source":{"id":"https://openalex.org/S62275304","display_name":"Journal of Digital Imaging","issn_l":"0897-1889","issn":["0897-1889","1618-727X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Digital Imaging","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3021843318.pdf","grobid_xml":"https://content.openalex.org/works/W3021843318.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W1903029394","https://openalex.org/W1993947467","https://openalex.org/W2015450881","https://openalex.org/W2108549165","https://openalex.org/W2119147717","https://openalex.org/W2133201432","https://openalex.org/W2153530160","https://openalex.org/W2162740426","https://openalex.org/W2194775991","https://openalex.org/W2301358467","https://openalex.org/W2383601426","https://openalex.org/W2395611524","https://openalex.org/W2531409750","https://openalex.org/W2598700764","https://openalex.org/W2742627598","https://openalex.org/W2761878534","https://openalex.org/W2883683269","https://openalex.org/W2898441006","https://openalex.org/W2941409406","https://openalex.org/W2962914239","https://openalex.org/W2963150697","https://openalex.org/W2963840672","https://openalex.org/W2964121744","https://openalex.org/W6602254124"],"related_works":["https://openalex.org/W4293226380","https://openalex.org/W4321487865","https://openalex.org/W4313906399","https://openalex.org/W4391266461","https://openalex.org/W2064573700","https://openalex.org/W2590798552","https://openalex.org/W2811106690","https://openalex.org/W4239306820","https://openalex.org/W2947043951","https://openalex.org/W4312417841"],"abstract_inverted_index":{"F-Fluorodeoxyglucose-positron":[0],"emission":[1],"tomography":[2],"(FDG-PET)":[3],"is":[4,29,84,182],"commonly":[5],"used":[6],"in":[7,26,73,133],"clinical":[8,11,131],"practice":[9],"and":[10,16,43,57,65,68,87,102,108,139,149,171],"drug":[12],"development":[13],"to":[14,33,62,69,75,89,125,188,192],"identify":[15,64],"quantify":[17],"metabolically":[18],"active":[19],"tumors.":[20],"Manual":[21],"or":[22],"computer-assisted":[23],"tumor":[24,35,100,195],"segmentation":[25],"FDG-PET":[27],"images":[28],"a":[30,120,156,172,183],"common":[31],"way":[32],"assess":[34,190],"burden,":[36],"such":[37],"approaches":[38],"are":[39],"both":[40],"labor":[41],"intensive":[42],"may":[44],"suffer":[45],"from":[46,129],"high":[47],"inter-reader":[48],"variability.":[49],"We":[50,154],"propose":[51],"an":[52,164],"end-to-end":[53],"method":[54,181],"leveraging":[55],"2D":[56],"3D":[58,158],"convolutional":[59],"neural":[60],"networks":[61],"rapidly":[63,189],"segment":[66],"tumors":[67],"extract":[70],"metabolic":[71],"information":[72],"eyes":[74,124,191],"thighs":[76,126,193],"(whole":[77],"body)":[78],"FDG-PET/CT":[79,127],"scans.":[80,179],"The":[81,180],"developed":[82],"architecture":[83],"computationally":[85],"efficient":[86],"devised":[88],"accommodate":[90],"the":[91,96,103,109,113],"size":[92],"of":[93,105,112,119,122,161,168],"whole-body":[94],"scans,":[95,128],"extreme":[97],"imbalance":[98],"between":[99],"burden":[101],"volume":[104],"healthy":[106],"tissue,":[107],"heterogeneous":[110],"nature":[111],"input":[114],"images.":[115],"Our":[116],"dataset":[117],"consists":[118],"total":[121],"3664":[123],"multi-site":[130],"trials":[132],"patients":[134],"with":[135],"non-Hodgkin's":[136],"lymphoma":[137],"(NHL)":[138],"advanced":[140],"non-small":[141],"cell":[142],"lung":[143],"cancer":[144],"(NSCLC).":[145],"Tumors":[146],"were":[147],"segmented":[148],"reviewed":[150],"by":[151],"board-certified":[152],"radiologists.":[153],"report":[155],"mean":[157],"Dice":[159],"score":[160],"88.6%":[162],"on":[163,175],"NHL":[165],"hold-out":[166,178],"set":[167],"1124":[169],"scans":[170],"93%":[173],"sensitivity":[174],"274":[176],"NSCLC":[177],"potential":[184],"tool":[185],"for":[186],"radiologists":[187],"FDG-avid":[194],"burden.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":1}],"updated_date":"2026-04-28T14:05:53.105641","created_date":"2025-10-10T00:00:00"}
