{"id":"https://openalex.org/W3191003990","doi":"https://doi.org/10.1007/s00521-021-06357-0","title":"A deep embedded refined clustering approach for breast cancer distinction based on DNA methylation","display_name":"A deep embedded refined clustering approach for breast cancer distinction based on DNA methylation","publication_year":2021,"publication_date":"2021-07-31","ids":{"openalex":"https://openalex.org/W3191003990","doi":"https://doi.org/10.1007/s00521-021-06357-0","mag":"3191003990"},"language":"en","primary_location":{"id":"doi:10.1007/s00521-021-06357-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00521-021-06357-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00521-021-06357-0.pdf","source":{"id":"https://openalex.org/S147897268","display_name":"Neural Computing and Applications","issn_l":"0941-0643","issn":["0941-0643","1433-3058"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computing and Applications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00521-021-06357-0.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067714499","display_name":"Roc\u00edo del Amor","orcid":"https://orcid.org/0000-0002-5342-2093"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Roc\u00edo del Amor","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, I3B, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, 46022, Valencia, Spain"],"raw_orcid":"https://orcid.org/0000-0002-5342-2093","affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, I3B, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, 46022, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019517367","display_name":"Adri\u00e1n Colomer","orcid":"https://orcid.org/0000-0002-7616-6029"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adri\u00e1n Colomer","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, I3B, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, 46022, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, I3B, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, 46022, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030244533","display_name":"Carlos Monteagudo","orcid":"https://orcid.org/0000-0002-9381-9976"},"institutions":[{"id":"https://openalex.org/I16097986","display_name":"Universitat de Val\u00e8ncia","ror":"https://ror.org/043nxc105","country_code":"ES","type":"education","lineage":["https://openalex.org/I16097986"]},{"id":"https://openalex.org/I4210094406","display_name":"Hospital Cl\u00ednico Universitario de Valencia","ror":"https://ror.org/00hpnj894","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210094406"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Monteagudo","raw_affiliation_strings":["Pathology Department, Hospital Cl\u00ednico Universitario de Valencia, Universidad de Valencia, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Cl\u00ednico Universitario de Valencia, Universidad de Valencia, Valencia, Spain","institution_ids":["https://openalex.org/I16097986","https://openalex.org/I4210094406"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043316752","display_name":"Valery Naranjo","orcid":"https://orcid.org/0000-0002-0181-3412"},"institutions":[{"id":"https://openalex.org/I60053951","display_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","ror":"https://ror.org/01460j859","country_code":"ES","type":"education","lineage":["https://openalex.org/I60053951"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Valery Naranjo","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, I3B, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, 46022, Valencia, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Bioingenier\u00eda, I3B, Universitat Polit\u00e8cnica de Val\u00e8ncia, Camino de Vera s/n, 46022, Valencia, Spain","institution_ids":["https://openalex.org/I60053951"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5067714499"],"corresponding_institution_ids":["https://openalex.org/I60053951"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2990,"currency":"USD","value_usd":2990},"fwci":1.9253,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.86962901,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"34","issue":"13","first_page":"10243","last_page":"10255"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10627","display_name":"Advanced Image and Video Retrieval Techniques","score":0.9498999714851379,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9431999921798706,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoencoder","display_name":"Autoencoder","score":0.807895302772522},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.7110996842384338},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6442423462867737},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6221721768379211},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5996843576431274},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"Breast cancer","score":0.5726560354232788},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.5402516722679138},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.514831006526947},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.490582138299942},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.4467431306838989},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.4383719265460968},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.43310344219207764},{"id":"https://openalex.org/keywords/word-error-rate","display_name":"Word error rate","score":0.42160531878471375},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.4085747003555298},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.34032097458839417},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.327308714389801},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.24000594019889832},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.15867355465888977},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10345900058746338},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.07617765665054321}],"concepts":[{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.807895302772522},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.7110996842384338},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6442423462867737},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6221721768379211},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5996843576431274},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.5726560354232788},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.5402516722679138},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.514831006526947},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.490582138299942},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4467431306838989},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.4383719265460968},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.43310344219207764},{"id":"https://openalex.org/C40969351","wikidata":"https://www.wikidata.org/wiki/Q3516228","display_name":"Word error rate","level":2,"score":0.42160531878471375},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.4085747003555298},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34032097458839417},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.327308714389801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24000594019889832},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.15867355465888977},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10345900058746338},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07617765665054321},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s00521-021-06357-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00521-021-06357-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00521-021-06357-0.pdf","source":{"id":"https://openalex.org/S147897268","display_name":"Neural Computing and Applications","issn_l":"0941-0643","issn":["0941-0643","1433-3058"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computing and Applications","raw_type":"journal-article"},{"id":"pmh:oai:riunet.upv.es:10251/179754","is_oa":true,"landing_page_url":"http://hdl.handle.net/10251/179754","pdf_url":null,"source":{"id":"https://openalex.org/S4306400639","display_name":"RiuNet (Universitat Polit\u00e8cnica de Val\u00e8ncia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I60053951","host_organization_name":"Universitat Polit\u00e8cnica de Val\u00e8ncia","host_organization_lineage":["https://openalex.org/I60053951"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1007/s00521-021-06357-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00521-021-06357-0","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00521-021-06357-0.pdf","source":{"id":"https://openalex.org/S147897268","display_name":"Neural Computing and Applications","issn_l":"0941-0643","issn":["0941-0643","1433-3058"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Computing and Applications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6899999976158142}],"awards":[{"id":"https://openalex.org/G2300613588","display_name":"CLoud ARtificial Intelligence For pathologY","funder_award_id":"860627","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2374808697","display_name":null,"funder_award_id":"PID2019-105142RB-C21","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G3133865805","display_name":null,"funder_award_id":"DPI2016-77869","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G4292344142","display_name":null,"funder_award_id":"860627","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G5221953459","display_name":null,"funder_award_id":"2019/109","funder_id":"https://openalex.org/F4320321864","funder_display_name":"Generalitat Valenciana"},{"id":"https://openalex.org/G8121320623","display_name":null,"funder_award_id":"DPI2016-77869-C2-1-R","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320309480","display_name":"Nvidia","ror":"https://ror.org/03jdj4y14"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320321864","display_name":"Generalitat Valenciana","ror":"https://ror.org/0097mvx21"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3191003990.pdf","grobid_xml":"https://content.openalex.org/works/W3191003990.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1965262464","https://openalex.org/W1979362779","https://openalex.org/W2017502278","https://openalex.org/W2056040742","https://openalex.org/W2072831163","https://openalex.org/W2074746593","https://openalex.org/W2093172432","https://openalex.org/W2096330673","https://openalex.org/W2131971406","https://openalex.org/W2187089797","https://openalex.org/W2221409856","https://openalex.org/W2341171179","https://openalex.org/W2410426698","https://openalex.org/W2520450246","https://openalex.org/W2765741717","https://openalex.org/W2884851420","https://openalex.org/W2894989903","https://openalex.org/W2895120143","https://openalex.org/W2908698261","https://openalex.org/W2937917790","https://openalex.org/W2964074409","https://openalex.org/W2978853725","https://openalex.org/W2980305541","https://openalex.org/W2985397232","https://openalex.org/W2990633537","https://openalex.org/W2991254538","https://openalex.org/W3035918293","https://openalex.org/W3040063571","https://openalex.org/W3099071781","https://openalex.org/W4235169531","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W3013693939","https://openalex.org/W2566616303","https://openalex.org/W2159052453","https://openalex.org/W3131327266","https://openalex.org/W2734887215","https://openalex.org/W4297051394","https://openalex.org/W2752972570","https://openalex.org/W4310873165","https://openalex.org/W2355395139","https://openalex.org/W4285596704"],"abstract_inverted_index":{"Abstract":[0],"Epigenetic":[1,15],"alterations":[2],"have":[3,148],"an":[4,98,168,175,199,204],"important":[5],"role":[6],"in":[7,88],"the":[8,58,65,89,93,109,113,118,139,142,151,191,221,230],"development":[9],"of":[10,13,21,32,67,80,92,112,131,141,172,179,190,201,208],"several":[11],"types":[12],"cancer.":[14],"studies":[16,147],"generate":[17],"a":[18,42,104,126,187,195],"large":[19],"amount":[20],"data,":[22],"which":[23],"makes":[24],"it":[25],"essential":[26],"to":[27,156],"develop":[28],"novel":[29],"models":[30],"capable":[31],"dealing":[33],"with":[34],"large-scale":[35],"data.":[36,241],"In":[37,56],"this":[38],"work,":[39],"we":[40],"propose":[41],"deep":[43,59],"embedded":[44],"refined":[45],"clustering":[46,105,170],"method":[47,122,166,193],"for":[48,160,233],"breast":[49,183,212,234],"cancer":[50,235],"differentiation":[51],"based":[52,96,107,237],"on":[53,97,108,150,181,210,218,238],"DNA":[54,161,239],"methylation.":[55],"concrete,":[57],"learning":[60],"system":[61],"presented":[62],"here":[63],"uses":[64],"levels":[66],"CpG":[68],"island":[69],"methylation":[70,94,162,197,240],"between":[71],"0":[72],"and":[73,135,174,203],"1.":[74],"The":[75,84,100,120,164],"proposed":[76,165,222],"approach":[77],"is":[78,103,123],"composed":[79,130],"two":[81,132],"main":[82],"stages.":[83],"first":[85],"stage":[86,102],"consists":[87],"dimensionality":[90,152],"reduction":[91,153],"data":[95],"autoencoder.":[99,119],"second":[101,188],"algorithm":[106,223],"soft":[110],"assignment":[111],"latent":[114],"space":[115],"provided":[116],"by":[117],"whole":[121],"optimized":[124],"through":[125],"weighted":[127],"loss":[128],"function":[129],"terms:":[133],"reconstruction":[134],"classification":[136,157,236],"terms.":[137],"To":[138],"best":[140],"authors\u2019":[143],"knowledge,":[144],"no":[145],"previous":[146],"focused":[149],"algorithms":[154],"linked":[155],"trained":[158],"end-to-end":[159],"analysis.":[163],"achieves":[167],"unsupervised":[169],"accuracy":[171,200],"0.9927":[173],"error":[176,205],"rate":[177,206],"(%)":[178,207],"0.73":[180],"137":[182],"tissue":[184,213],"samples.":[185],"After":[186],"test":[189],"deep-learning-based":[192],"using":[194],"different":[196],"database,":[198],"0.9343":[202],"6.57":[209],"45":[211],"samples":[214],"are":[215],"obtained.":[216],"Based":[217],"these":[219],"results,":[220],"outperforms":[224],"other":[225],"state-of-the-art":[226],"methods":[227],"evaluated":[228],"under":[229],"same":[231],"conditions":[232]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3}],"updated_date":"2026-07-31T08:31:51.225901","created_date":"2025-10-10T00:00:00"}
