{"id":"https://openalex.org/W2943075027","doi":"https://doi.org/10.1007/s00422-020-00846-6","title":"Optimizing enzymatic catalysts for rapid turnover of substrates with low enzyme sequestration","display_name":"Optimizing enzymatic catalysts for rapid turnover of substrates with low enzyme sequestration","publication_year":2020,"publication_date":"2020-10-12","ids":{"openalex":"https://openalex.org/W2943075027","doi":"https://doi.org/10.1007/s00422-020-00846-6","mag":"2943075027","pmid":"https://pubmed.ncbi.nlm.nih.gov/33044662"},"language":"en","primary_location":{"id":"doi:10.1007/s00422-020-00846-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00422-020-00846-6","pdf_url":null,"source":{"id":"https://openalex.org/S87357125","display_name":"Biological Cybernetics","issn_l":"0340-1200","issn":["0340-1200","1432-0770"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Cybernetics","raw_type":"journal-article"},"type":"preprint","indexed_in":["arxiv","crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1905.00555","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002062233","display_name":"Abhishek Deshpande","orcid":"https://orcid.org/0000-0003-0163-6564"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abhishek Deshpande","raw_affiliation_strings":["Department of Mathematics, University of Wisconin Madison, Madison, 53706, WI, United States of America","University of Wisconsin-Madison, #TAB#"],"raw_orcid":"https://orcid.org/0000-0003-0163-6564","affiliations":[{"raw_affiliation_string":"Department of Mathematics, University of Wisconin Madison, Madison, 53706, WI, United States of America","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"University of Wisconsin-Madison, #TAB#","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025227332","display_name":"Thomas E. Ouldridge","orcid":"https://orcid.org/0000-0001-8114-8602"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas E. Ouldridge","raw_affiliation_strings":["Imperial College Centre for Synthetic Biology and Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. t.ouldridge@imperial.ac.uk","Imperial College Centre for Synthetic Biology and Department of Bioengineering, Imperial College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial College Centre for Synthetic Biology and Department of Bioengineering, Imperial College London, London, SW7 2AZ, UK. t.ouldridge@imperial.ac.uk","institution_ids":["https://openalex.org/I47508984"]},{"raw_affiliation_string":"Imperial College Centre for Synthetic Biology and Department of Bioengineering, Imperial College London, London, UK","institution_ids":["https://openalex.org/I47508984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2790,"currency":"EUR","value_usd":3590},"apc_paid":null,"fwci":0.0834,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.4239317,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"114","issue":"6","first_page":"653","last_page":"668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10303","display_name":"Photosynthetic Processes and Mechanisms","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/catalysis","display_name":"Catalysis","score":0.7118371725082397},{"id":"https://openalex.org/keywords/substrate","display_name":"Substrate (aquarium)","score":0.6482454538345337},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.6181440353393555},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6074907779693604},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.6016904711723328},{"id":"https://openalex.org/keywords/binding-energy","display_name":"Binding energy","score":0.5172358155250549},{"id":"https://openalex.org/keywords/free-product","display_name":"Free product","score":0.4608897566795349},{"id":"https://openalex.org/keywords/enzyme-catalysis","display_name":"Enzyme catalysis","score":0.42707303166389465},{"id":"https://openalex.org/keywords/reaction-rate","display_name":"Reaction rate","score":0.4114115238189697},{"id":"https://openalex.org/keywords/product","display_name":"Product (mathematics)","score":0.410386323928833},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.380990594625473},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.2057092785835266},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.15794247388839722},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.13147148489952087},{"id":"https://openalex.org/keywords/atomic-physics","display_name":"Atomic physics","score":0.1261369287967682},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10468977689743042},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09034362435340881}],"concepts":[{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.7118371725082397},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.6482454538345337},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.6181440353393555},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6074907779693604},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6016904711723328},{"id":"https://openalex.org/C93282013","wikidata":"https://www.wikidata.org/wiki/Q420754","display_name":"Binding energy","level":2,"score":0.5172358155250549},{"id":"https://openalex.org/C47527751","wikidata":"https://www.wikidata.org/wiki/Q1454165","display_name":"Free product","level":3,"score":0.4608897566795349},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.42707303166389465},{"id":"https://openalex.org/C175113610","wikidata":"https://www.wikidata.org/wiki/Q3394849","display_name":"Reaction rate","level":3,"score":0.4114115238189697},{"id":"https://openalex.org/C90673727","wikidata":"https://www.wikidata.org/wiki/Q901718","display_name":"Product (mathematics)","level":2,"score":0.410386323928833},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.380990594625473},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.2057092785835266},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15794247388839722},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.13147148489952087},{"id":"https://openalex.org/C184779094","wikidata":"https://www.wikidata.org/wiki/Q26383","display_name":"Atomic physics","level":1,"score":0.1261369287967682},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10468977689743042},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09034362435340881},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1007/s00422-020-00846-6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00422-020-00846-6","pdf_url":null,"source":{"id":"https://openalex.org/S87357125","display_name":"Biological Cybernetics","issn_l":"0340-1200","issn":["0340-1200","1432-0770"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological Cybernetics","raw_type":"journal-article"},{"id":"pmid:33044662","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33044662","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological cybernetics","raw_type":null},{"id":"pmh:oai:arXiv.org:1905.00555","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1905.00555","pdf_url":"https://arxiv.org/pdf/1905.00555","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2943075027","is_oa":true,"landing_page_url":"http://export.arxiv.org/pdf/1905.00555","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"pmh:oai:spiral.imperial.ac.uk:10044/1/85338","is_oa":false,"landing_page_url":"http://hdl.handle.net/10044/1/85338","pdf_url":null,"source":{"id":"https://openalex.org/S4306401396","display_name":"Spiral (Imperial College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I47508984","host_organization_name":"Imperial College London","host_organization_lineage":["https://openalex.org/I47508984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"668","raw_type":"Journal Article"},{"id":"doi:10.48550/arxiv.1905.00555","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1905.00555","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1905.00555","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1905.00555","pdf_url":"https://arxiv.org/pdf/1905.00555","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.47999998927116394,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":66,"referenced_works":["https://openalex.org/W1510479004","https://openalex.org/W1563426240","https://openalex.org/W1576666627","https://openalex.org/W1593075457","https://openalex.org/W1771886792","https://openalex.org/W1869042642","https://openalex.org/W1964504843","https://openalex.org/W1964756055","https://openalex.org/W1965076207","https://openalex.org/W1968606500","https://openalex.org/W1972657716","https://openalex.org/W1975353473","https://openalex.org/W1987696643","https://openalex.org/W2003501808","https://openalex.org/W2008875008","https://openalex.org/W2009008752","https://openalex.org/W2013676609","https://openalex.org/W2014670037","https://openalex.org/W2030205108","https://openalex.org/W2030742563","https://openalex.org/W2037339623","https://openalex.org/W2041603328","https://openalex.org/W2049020763","https://openalex.org/W2055214702","https://openalex.org/W2060161932","https://openalex.org/W2062931536","https://openalex.org/W2062936056","https://openalex.org/W2063080802","https://openalex.org/W2065024011","https://openalex.org/W2066381187","https://openalex.org/W2070658593","https://openalex.org/W2071131107","https://openalex.org/W2071423255","https://openalex.org/W2074616759","https://openalex.org/W2076316042","https://openalex.org/W2082260955","https://openalex.org/W2097110590","https://openalex.org/W2102485933","https://openalex.org/W2105984138","https://openalex.org/W2124892319","https://openalex.org/W2138358136","https://openalex.org/W2166499263","https://openalex.org/W2186962916","https://openalex.org/W2238266207","https://openalex.org/W2247294682","https://openalex.org/W2270973704","https://openalex.org/W2314693860","https://openalex.org/W2497237190","https://openalex.org/W2522193263","https://openalex.org/W2580403151","https://openalex.org/W2590202030","https://openalex.org/W2754905677","https://openalex.org/W2761766018","https://openalex.org/W2765985933","https://openalex.org/W2783893042","https://openalex.org/W2963625100","https://openalex.org/W2980231968","https://openalex.org/W2983083334","https://openalex.org/W2986739588","https://openalex.org/W3027131444","https://openalex.org/W3027163008","https://openalex.org/W3028388550","https://openalex.org/W3122662640","https://openalex.org/W3165523566","https://openalex.org/W4251170832","https://openalex.org/W6611713002"],"related_works":["https://openalex.org/W2028017072","https://openalex.org/W84748094","https://openalex.org/W2138374861","https://openalex.org/W2434324911","https://openalex.org/W2738334646","https://openalex.org/W2095368323","https://openalex.org/W2405554446","https://openalex.org/W50239912","https://openalex.org/W2018656720","https://openalex.org/W1990663454","https://openalex.org/W2463700396","https://openalex.org/W1999510423","https://openalex.org/W2398597526","https://openalex.org/W1995798009","https://openalex.org/W1986895790","https://openalex.org/W1556832027","https://openalex.org/W2080635588","https://openalex.org/W2387303036","https://openalex.org/W2030282707","https://openalex.org/W2132851597"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}