{"id":"https://openalex.org/W2800654784","doi":"https://doi.org/10.1007/s00138-018-0934-y","title":"An efficient and robust hybrid method for segmentation of zebrafish objects from bright-field microscope images","display_name":"An efficient and robust hybrid method for segmentation of zebrafish objects from bright-field microscope images","publication_year":2018,"publication_date":"2018-05-10","ids":{"openalex":"https://openalex.org/W2800654784","doi":"https://doi.org/10.1007/s00138-018-0934-y","mag":"2800654784","pmid":"https://pubmed.ncbi.nlm.nih.gov/30930547"},"language":"en","primary_location":{"id":"doi:10.1007/s00138-018-0934-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00138-018-0934-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00138-018-0934-y.pdf","source":{"id":"https://openalex.org/S27728525","display_name":"Machine Vision and Applications","issn_l":"0932-8092","issn":["0932-8092","1432-1769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Machine Vision and Applications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00138-018-0934-y.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011096681","display_name":"Yuanhao Guo","orcid":"https://orcid.org/0000-0003-4797-1616"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Yuanhao Guo","raw_affiliation_strings":["Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands","Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-4797-1616","affiliations":[{"raw_affiliation_string":"Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060587270","display_name":"Zhan Xiong","orcid":"https://orcid.org/0000-0002-3378-3561"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zhan Xiong","raw_affiliation_strings":["Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands","Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022631255","display_name":"Fons J. Verbeek","orcid":"https://orcid.org/0000-0003-2445-8158"},"institutions":[{"id":"https://openalex.org/I121797337","display_name":"Leiden University","ror":"https://ror.org/027bh9e22","country_code":"NL","type":"education","lineage":["https://openalex.org/I121797337"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Fons J. Verbeek","raw_affiliation_strings":["Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands","Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]},{"raw_affiliation_string":"Imaging & BioInformatics, LIACS, Leiden University, Niels Bohrweg 1, 2333 CA, Leiden, The Netherlands","institution_ids":["https://openalex.org/I121797337"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011096681"],"corresponding_institution_ids":["https://openalex.org/I121797337"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.427,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.75378886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"29","issue":"8","first_page":"1211","last_page":"1225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10531","display_name":"Advanced Vision and Imaging","score":0.9943000078201294,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9922999739646912,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.8042693138122559},{"id":"https://openalex.org/keywords/zebrafish","display_name":"Zebrafish","score":0.7406587600708008},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.7332528829574585},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.6749338507652283},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6500258445739746},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.5824629664421082},{"id":"https://openalex.org/keywords/scale-space-segmentation","display_name":"Scale-space segmentation","score":0.5795916318893433},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5394800901412964},{"id":"https://openalex.org/keywords/segmentation-based-object-categorization","display_name":"Segmentation-based object categorization","score":0.4515206515789032},{"id":"https://openalex.org/keywords/heuristics","display_name":"Heuristics","score":0.4224601984024048},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18009203672409058}],"concepts":[{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.8042693138122559},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.7406587600708008},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.7332528829574585},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.6749338507652283},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6500258445739746},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.5824629664421082},{"id":"https://openalex.org/C65885262","wikidata":"https://www.wikidata.org/wiki/Q7429708","display_name":"Scale-space segmentation","level":4,"score":0.5795916318893433},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5394800901412964},{"id":"https://openalex.org/C25694479","wikidata":"https://www.wikidata.org/wiki/Q7446278","display_name":"Segmentation-based object categorization","level":5,"score":0.4515206515789032},{"id":"https://openalex.org/C127705205","wikidata":"https://www.wikidata.org/wiki/Q5748245","display_name":"Heuristics","level":2,"score":0.4224601984024048},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18009203672409058},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1007/s00138-018-0934-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00138-018-0934-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00138-018-0934-y.pdf","source":{"id":"https://openalex.org/S27728525","display_name":"Machine Vision and Applications","issn_l":"0932-8092","issn":["0932-8092","1432-1769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Machine Vision and Applications","raw_type":"journal-article"},{"id":"pmid:30930547","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30930547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Machine vision and applications","raw_type":null},{"id":"pmh:oai:europepmc.org:5415682","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6411218","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/68325","is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/68325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"29","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pubmedcentral.nih.gov:6411218","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6411218","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Mach Vis Appl","raw_type":"Text"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2970841","is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/68325","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Machine Vision and Applications","raw_type":"Article / Letter to editor"}],"best_oa_location":{"id":"doi:10.1007/s00138-018-0934-y","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00138-018-0934-y","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00138-018-0934-y.pdf","source":{"id":"https://openalex.org/S27728525","display_name":"Machine Vision and Applications","issn_l":"0932-8092","issn":["0932-8092","1432-1769"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Machine Vision and Applications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/16","score":0.6200000047683716,"display_name":"Peace, Justice and strong institutions"}],"awards":[{"id":"https://openalex.org/G4847772313","display_name":null,"funder_award_id":"834.14.001","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G5998852775","display_name":null,"funder_award_id":"201206220108","funder_id":"https://openalex.org/F4320322725","funder_display_name":"China Scholarship Council"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322725","display_name":"China Scholarship Council","ror":"https://ror.org/04atp4p48"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2800654784.pdf","grobid_xml":"https://content.openalex.org/works/W2800654784.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W332214200","https://openalex.org/W1569930776","https://openalex.org/W1901129140","https://openalex.org/W1903029394","https://openalex.org/W1910657905","https://openalex.org/W1973880112","https://openalex.org/W1991113069","https://openalex.org/W2022686119","https://openalex.org/W2034110104","https://openalex.org/W2038952578","https://openalex.org/W2040764314","https://openalex.org/W2059208704","https://openalex.org/W2067191022","https://openalex.org/W2077616844","https://openalex.org/W2104095591","https://openalex.org/W2104125540","https://openalex.org/W2114444010","https://openalex.org/W2116040950","https://openalex.org/W2129390138","https://openalex.org/W2132116135","https://openalex.org/W2133216625","https://openalex.org/W2134408326","https://openalex.org/W2135056195","https://openalex.org/W2136573752","https://openalex.org/W2141023795","https://openalex.org/W2145861118","https://openalex.org/W2147427282","https://openalex.org/W2147880316","https://openalex.org/W2154547421","https://openalex.org/W2155055620","https://openalex.org/W2155343350","https://openalex.org/W2163605009","https://openalex.org/W2164822588","https://openalex.org/W2201196057","https://openalex.org/W2228033847","https://openalex.org/W2286929393","https://openalex.org/W2395611524","https://openalex.org/W2522424083","https://openalex.org/W2560455603","https://openalex.org/W2579165277","https://openalex.org/W2608459997","https://openalex.org/W2738559815","https://openalex.org/W2963881378","https://openalex.org/W3101414261","https://openalex.org/W3211330693","https://openalex.org/W6602254124"],"related_works":["https://openalex.org/W3144569342","https://openalex.org/W2185902295","https://openalex.org/W2945274617","https://openalex.org/W2103507220","https://openalex.org/W2055202857","https://openalex.org/W2371519352","https://openalex.org/W4205800335","https://openalex.org/W2386644571","https://openalex.org/W2551987074","https://openalex.org/W2372421320"],"abstract_inverted_index":{"Accurate":[0],"segmentation":[1,46,87,122,140,156,213],"of":[2,47,88,113,128,163,183,211,214],"zebrafish":[3,18,27,48,89,185,216],"from":[4,50,91,138],"bright-field":[5,92],"microscope":[6,93],"images":[7,51],"is":[8,28,38,52,136,177],"crucial":[9],"to":[10,34,63,82,101,116,144,179,222],"many":[11],"applications":[12,227],"in":[13,23,41,56,71,106],"the":[14,26,42,65,97,103,107,111,114,117,125,129,160,164,174,181,184,190,202,212,215],"life":[15],"sciences.":[16],"Early":[17],"stages":[19,25],"are":[20,169,220],"used,":[21],"and":[22,74,85,119,142,173,209],"these":[24],"partially":[29],"transparent.":[30],"This":[31,109],"transparency":[32],"leads":[33],"edge":[35],"ambiguity":[36],"as":[37],"typically":[39],"seen":[40],"larval":[43],"stages.":[44],"Therefore,":[45],"objects":[49],"a":[53,79,121],"challenging":[54],"task":[55],"computational":[57,60],"bio-imaging.":[58],"Popular":[59],"methods":[61],"fail":[62],"segment":[64],"relevant":[66],"edges,":[67],"which":[68,158],"subsequently":[69],"results":[70,219],"inaccurate":[72],"measurements":[73],"evaluations.":[75],"Here":[76],"we":[77,152,199],"present":[78],"hybrid":[80,175,204],"method":[81,192,205],"accomplish":[83],"accurate":[84],"efficient":[86],"specimens":[90],"images.":[94,108],"We":[95,187],"employ":[96],"mean":[98],"shift":[99],"algorithm":[100],"augment":[102],"colour":[104],"representation":[105],"improves":[110,206],"discrimination":[112],"specimen":[115],"background":[118],"provides":[120],"candidate":[123,141,157],"retaining":[124],"overall":[126],"shape":[127],"zebrafish.":[130,229],"A":[131],"distance-regularised":[132],"level":[133,147],"set":[134,148],"function":[135],"initialised":[137],"this":[139],"fed":[143],"an":[145],"improved":[146],"method,":[149],"such":[150],"that":[151,201],"can":[153],"obtain":[154],"another":[155],"preserves":[159],"explicit":[161],"contour":[162,182],"object.":[165],"The":[166,218],"two":[167,194],"candidates":[168],"fused":[170],"using":[171],"heuristics,":[172],"result":[176],"refined":[178],"represent":[180],"specimen.":[186,217],"have":[188],"applied":[189],"proposed":[191,203],"on":[193],"typical":[195],"datasets.":[196],"From":[197],"experiments,":[198],"conclude":[200],"both":[207],"efficiency":[208],"accuracy":[210],"going":[221],"be":[223],"used":[224],"for":[225],"high-throughput":[226],"with":[228]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}
