{"id":"https://openalex.org/W2147666426","doi":"https://doi.org/10.1007/bf00124476","title":"The agonistic binding site at the histamine H2 receptor. I. Theoretical investigations of histamine binding to an oligopeptide mimicking a part of the fifth transmembrane \u03b1-helix","display_name":"The agonistic binding site at the histamine H2 receptor. I. Theoretical investigations of histamine binding to an oligopeptide mimicking a part of the fifth transmembrane \u03b1-helix","publication_year":1996,"publication_date":"1996-10-01","ids":{"openalex":"https://openalex.org/W2147666426","doi":"https://doi.org/10.1007/bf00124476","mag":"2147666426","pmid":"https://pubmed.ncbi.nlm.nih.gov/8951654"},"language":"en","primary_location":{"id":"doi:10.1007/bf00124476","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00124476","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103557732","display_name":"Paul H. J. Nederkoorn","orcid":null},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Paul H. J. Nederkoorn","raw_affiliation_strings":["Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, The Netherlands","Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109941865","display_name":"Joop H. van Lenthe","orcid":null},"institutions":[{"id":"https://openalex.org/I4210112966","display_name":"Instituto de F\u00edsica Te\u00f3rica","ror":"https://ror.org/022r8mj40","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210112966","https://openalex.org/I63634437"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["ES","NL"],"is_corresponding":false,"raw_author_name":"Joop H. van Lenthe","raw_affiliation_strings":["Theoretical Chemistry Group, Debije Institute, Utrecht University, Padualaan 14, 3584 CH, Utrecht, The Netherlands","Theoretical Chemistry Group, Debije Institute, Utrecht University, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Theoretical Chemistry Group, Debije Institute, Utrecht University, Padualaan 14, 3584 CH, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353","https://openalex.org/I4210112966"]},{"raw_affiliation_string":"Theoretical Chemistry Group, Debije Institute, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108807334","display_name":"H. van der Goot","orcid":null},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Henk van der Goot","raw_affiliation_strings":["Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands","Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064252280","display_name":"Gabri\u00eblle M. Donn\u00e9-Op den Kelder","orcid":null},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gabri\u00eblle M. Donn\u00e9-Op den Kelder","raw_affiliation_strings":["Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands","Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112783486","display_name":"Henk Timmerman","orcid":null},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Henk Timmerman","raw_affiliation_strings":["Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands","Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"Department of Pharmacochemistry, Leiden/Amsterdam Center for Drug Research (LACDR), Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5103557732"],"corresponding_institution_ids":["https://openalex.org/I865915315"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":0.9575,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.75684269,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"10","issue":"5","first_page":"461","last_page":"478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligopeptide","display_name":"Oligopeptide","score":0.7924604415893555},{"id":"https://openalex.org/keywords/histamine","display_name":"Histamine","score":0.7703777551651001},{"id":"https://openalex.org/keywords/agonistic-behaviour","display_name":"Agonistic behaviour","score":0.7678971290588379},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5131235718727112},{"id":"https://openalex.org/keywords/transmembrane-domain","display_name":"Transmembrane domain","score":0.4998338222503662},{"id":"https://openalex.org/keywords/transmembrane-protein","display_name":"Transmembrane protein","score":0.49445366859436035},{"id":"https://openalex.org/keywords/helix","display_name":"Helix (gastropod)","score":0.45923882722854614},{"id":"https://openalex.org/keywords/histamine-h4-receptor","display_name":"Histamine H4 receptor","score":0.45690786838531494},{"id":"https://openalex.org/keywords/binding-site","display_name":"Binding site","score":0.45309311151504517},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.44145667552948},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.4392828941345215},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4065524935722351},{"id":"https://openalex.org/keywords/histamine-h2-receptor","display_name":"Histamine H2 receptor","score":0.363044410943985},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2520807981491089},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.250654935836792},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.240034818649292},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.16559138894081116},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.1414942741394043},{"id":"https://openalex.org/keywords/zoology","display_name":"Zoology","score":0.08454030752182007},{"id":"https://openalex.org/keywords/antagonist","display_name":"Antagonist","score":0.06587517261505127}],"concepts":[{"id":"https://openalex.org/C13935069","wikidata":"https://www.wikidata.org/wiki/Q2157266","display_name":"Oligopeptide","level":3,"score":0.7924604415893555},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.7703777551651001},{"id":"https://openalex.org/C187898756","wikidata":"https://www.wikidata.org/wiki/Q395324","display_name":"Agonistic behaviour","level":3,"score":0.7678971290588379},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5131235718727112},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.4998338222503662},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.49445366859436035},{"id":"https://openalex.org/C2778530040","wikidata":"https://www.wikidata.org/wiki/Q1937315","display_name":"Helix (gastropod)","level":3,"score":0.45923882722854614},{"id":"https://openalex.org/C30862142","wikidata":"https://www.wikidata.org/wiki/Q288382","display_name":"Histamine H4 receptor","level":5,"score":0.45690786838531494},{"id":"https://openalex.org/C107824862","wikidata":"https://www.wikidata.org/wiki/Q616005","display_name":"Binding site","level":2,"score":0.45309311151504517},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.44145667552948},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4392828941345215},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4065524935722351},{"id":"https://openalex.org/C34400551","wikidata":"https://www.wikidata.org/wiki/Q311568","display_name":"Histamine H2 receptor","level":4,"score":0.363044410943985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2520807981491089},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.250654935836792},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.240034818649292},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.16559138894081116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1414942741394043},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.08454030752182007},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.06587517261505127},{"id":"https://openalex.org/C2779448149","wikidata":"https://www.wikidata.org/wiki/Q191797","display_name":"Aggression","level":2,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C2780252984","wikidata":"https://www.wikidata.org/wiki/Q4867740","display_name":"Gastropoda","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011970","descriptor_name":"Receptors, Histamine H2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017076","descriptor_name":"Computer-Aided Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017076","descriptor_name":"Computer-Aided Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017076","descriptor_name":"Computer-Aided Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017442","descriptor_name":"Histamine Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017442","descriptor_name":"Histamine Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017442","descriptor_name":"Histamine Agonists","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/bf00124476","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00124476","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:8951654","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8951654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null},{"id":"pmh:vu:oai:research.vu.nl:publications/a5579601-996b-4992-b895-26534109be41","is_oa":false,"landing_page_url":"https://research.vu.nl/en/publications/a5579601-996b-4992-b895-26534109be41","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Computer-aided Molecular Design, 10, 461 - 478. Springer Netherlands","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W637501784","https://openalex.org/W1493538310","https://openalex.org/W1970389871","https://openalex.org/W1975702539","https://openalex.org/W1979263745","https://openalex.org/W1980899216","https://openalex.org/W2016912149","https://openalex.org/W2021618958","https://openalex.org/W2035100851","https://openalex.org/W2039771104","https://openalex.org/W2040986918","https://openalex.org/W2046221309","https://openalex.org/W2049521571","https://openalex.org/W2049553830","https://openalex.org/W2065875666","https://openalex.org/W2067492849","https://openalex.org/W2075662564","https://openalex.org/W2078703954","https://openalex.org/W2091748192","https://openalex.org/W2101831743","https://openalex.org/W2114621223","https://openalex.org/W2148941593","https://openalex.org/W2412314192","https://openalex.org/W2430462957","https://openalex.org/W4211143939"],"related_works":["https://openalex.org/W1973858289","https://openalex.org/W2888752514","https://openalex.org/W2036774297","https://openalex.org/W1983461608","https://openalex.org/W2155652189","https://openalex.org/W1970895266","https://openalex.org/W4376225150","https://openalex.org/W1982404225","https://openalex.org/W593353776","https://openalex.org/W2564431776"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2016-06-24T00:00:00"}
