{"id":"https://openalex.org/W1999998965","doi":"https://doi.org/10.1007/bf00124360","title":"A Monte Carlo pharmacophore generation procedure: Application to the human PAF receptor","display_name":"A Monte Carlo pharmacophore generation procedure: Application to the human PAF receptor","publication_year":1993,"publication_date":"1993-10-01","ids":{"openalex":"https://openalex.org/W1999998965","doi":"https://doi.org/10.1007/bf00124360","mag":"1999998965","pmid":"https://pubmed.ncbi.nlm.nih.gov/8294944"},"language":"en","primary_location":{"id":"doi:10.1007/bf00124360","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00124360","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074570437","display_name":"Edward E. Hodgkin","orcid":null},"institutions":[{"id":"https://openalex.org/I868599081","display_name":"BTG International (United Kingdom)","ror":"https://ror.org/05c691y47","country_code":"GB","type":"company","lineage":["https://openalex.org/I868599081"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Edward E. Hodgkin","raw_affiliation_strings":["British Bio-technology Ltd., Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Bio-technology Ltd., Oxford, U.K","institution_ids":["https://openalex.org/I868599081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006882267","display_name":"A. L. Miller","orcid":"https://orcid.org/0000-0002-4890-7627"},"institutions":[{"id":"https://openalex.org/I2800081431","display_name":"British Academy","ror":"https://ror.org/0302b4677","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800081431"]},{"id":"https://openalex.org/I868599081","display_name":"BTG International (United Kingdom)","ror":"https://ror.org/05c691y47","country_code":"GB","type":"company","lineage":["https://openalex.org/I868599081"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Miller","raw_affiliation_strings":["British Bio-technology Ltd., Watlington Road, OX4 5LY, Oxford, U.K","British Bio-technology Ltd., Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Bio-technology Ltd., Watlington Road, OX4 5LY, Oxford, U.K","institution_ids":["https://openalex.org/I2800081431"]},{"raw_affiliation_string":"British Bio-technology Ltd., Oxford, U.K","institution_ids":["https://openalex.org/I868599081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110281997","display_name":"Mark Whittaker","orcid":null},"institutions":[{"id":"https://openalex.org/I2800081431","display_name":"British Academy","ror":"https://ror.org/0302b4677","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I2800081431"]},{"id":"https://openalex.org/I868599081","display_name":"BTG International (United Kingdom)","ror":"https://ror.org/05c691y47","country_code":"GB","type":"company","lineage":["https://openalex.org/I868599081"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark Whittaker","raw_affiliation_strings":["British Bio-technology Ltd., Watlington Road, OX4 5LY, Oxford, U.K","British Bio-technology Ltd., Oxford, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"British Bio-technology Ltd., Watlington Road, OX4 5LY, Oxford, U.K","institution_ids":["https://openalex.org/I2800081431"]},{"raw_affiliation_string":"British Bio-technology Ltd., Oxford, U.K","institution_ids":["https://openalex.org/I868599081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":null,"fwci":1.2153,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.778989,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"7","issue":"5","first_page":"515","last_page":"534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11460","display_name":"Analytical Methods in Pharmaceuticals","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9879999756813049,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacophore","display_name":"Pharmacophore","score":0.9596397876739502},{"id":"https://openalex.org/keywords/monte-carlo-method","display_name":"Monte Carlo method","score":0.6620692610740662},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.44813427329063416},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.43408337235450745},{"id":"https://openalex.org/keywords/simulated-annealing","display_name":"Simulated annealing","score":0.41237393021583557},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3889774680137634},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3154338002204895},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.3126232624053955},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2218499481678009},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2214614748954773},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16925951838493347},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1471845507621765}],"concepts":[{"id":"https://openalex.org/C56173144","wikidata":"https://www.wikidata.org/wiki/Q1539893","display_name":"Pharmacophore","level":2,"score":0.9596397876739502},{"id":"https://openalex.org/C19499675","wikidata":"https://www.wikidata.org/wiki/Q232207","display_name":"Monte Carlo method","level":2,"score":0.6620692610740662},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44813427329063416},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43408337235450745},{"id":"https://openalex.org/C126980161","wikidata":"https://www.wikidata.org/wiki/Q863783","display_name":"Simulated annealing","level":2,"score":0.41237393021583557},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3889774680137634},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3154338002204895},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3126232624053955},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2218499481678009},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2214614748954773},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16925951838493347},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1471845507621765},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010972","descriptor_name":"Platelet Activating Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010980","descriptor_name":"Platelet Membrane Glycoproteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf00124360","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf00124360","pdf_url":null,"source":{"id":"https://openalex.org/S64621741","display_name":"Journal of Computer-Aided Molecular Design","issn_l":"0920-654X","issn":["0920-654X","1573-4951"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computer-Aided Molecular Design","raw_type":"journal-article"},{"id":"pmid:8294944","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8294944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computer-aided molecular design","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7","score":0.8899999856948853}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W644860508","https://openalex.org/W650893053","https://openalex.org/W1972243809","https://openalex.org/W1976137476","https://openalex.org/W1978229492","https://openalex.org/W1982141201","https://openalex.org/W1984776927","https://openalex.org/W1985616236","https://openalex.org/W1995484623","https://openalex.org/W1999297737","https://openalex.org/W2030676639","https://openalex.org/W2033106171","https://openalex.org/W2043382734","https://openalex.org/W2043934481","https://openalex.org/W2050251045","https://openalex.org/W2052607605","https://openalex.org/W2053333781","https://openalex.org/W2056760934","https://openalex.org/W2057384013","https://openalex.org/W2059530451","https://openalex.org/W2064683594","https://openalex.org/W2066224698","https://openalex.org/W2072555086","https://openalex.org/W2078787710","https://openalex.org/W2080563827","https://openalex.org/W2084550441","https://openalex.org/W2089526089","https://openalex.org/W2093980638","https://openalex.org/W2111558474","https://openalex.org/W2141178517","https://openalex.org/W2161239029","https://openalex.org/W2162166182","https://openalex.org/W2166392415","https://openalex.org/W2241823605","https://openalex.org/W2433302053","https://openalex.org/W4244676158","https://openalex.org/W6603918287","https://openalex.org/W6613591007","https://openalex.org/W6829287214"],"related_works":["https://openalex.org/W3184587995","https://openalex.org/W2943414817","https://openalex.org/W1605005150","https://openalex.org/W3092402433","https://openalex.org/W2385923153","https://openalex.org/W2902128418","https://openalex.org/W2511683653","https://openalex.org/W187265897","https://openalex.org/W4255394524","https://openalex.org/W2181313142"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-07-23T08:03:31.855105","created_date":"2025-10-10T00:00:00"}