{"id":"https://openalex.org/W29135762","doi":"https://doi.org/10.1007/978-3-642-37137-0_12","title":"Identifying Gene Knockout Strategy Using Bees Hill Flux Balance Analysis (BHFBA) for Improving the Production of Ethanol in Bacillus Subtilis","display_name":"Identifying Gene Knockout Strategy Using Bees Hill Flux Balance Analysis (BHFBA) for Improving the Production of Ethanol in Bacillus Subtilis","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W29135762","doi":"https://doi.org/10.1007/978-3-642-37137-0_12","mag":"29135762"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-37137-0_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-37137-0_12","pdf_url":null,"source":{"id":"https://openalex.org/S2764461748","display_name":"Studies in computational intelligence","issn_l":"1860-949X","issn":["1860-949X","1860-9503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Computational Intelligence","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081045152","display_name":"Yee Wen Choon","orcid":"https://orcid.org/0000-0003-0787-5945"},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":true,"raw_author_name":"Yee Wen Choon","raw_affiliation_strings":["Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085034566","display_name":"Mohd Saberi Mohamad","orcid":"https://orcid.org/0000-0002-1079-4559"},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Mohd Saberi Mohamad","raw_affiliation_strings":["Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108483457","display_name":"Safaai Deris","orcid":null},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Safaai Deris","raw_affiliation_strings":["Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112470879","display_name":"Rosli Md. Illias","orcid":null},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Rosli M. Illias","raw_affiliation_strings":["Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioprocess Engineering, Faculty of Chemical Engineering, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069051802","display_name":"Lian En Chai","orcid":null},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Lian En Chai","raw_affiliation_strings":["Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059076481","display_name":"Chuii Khim Chong","orcid":null},"institutions":[{"id":"https://openalex.org/I4576418","display_name":"University of Technology Malaysia","ror":"https://ror.org/026w31v75","country_code":"MY","type":"education","lineage":["https://openalex.org/I4576418"]}],"countries":["MY"],"is_corresponding":false,"raw_author_name":"Chuii Khim Chong","raw_affiliation_strings":["Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Artificial Intelligence and Bioinformatics Research Group, Faculty of Computer Science and Information Systems, Universiti Teknologi Malaysia, Skudai, 81310, Johor, Malaysia","institution_ids":["https://openalex.org/I4576418"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081045152"],"corresponding_institution_ids":["https://openalex.org/I4576418"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.01235722,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"117","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9797999858856201,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.8261514902114868},{"id":"https://openalex.org/keywords/flux-balance-analysis","display_name":"Flux balance analysis","score":0.7403213977813721},{"id":"https://openalex.org/keywords/yield","display_name":"Yield (engineering)","score":0.5149974822998047},{"id":"https://openalex.org/keywords/gene-knockout","display_name":"Gene knockout","score":0.5019645690917969},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.4673497974872589},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.46361809968948364},{"id":"https://openalex.org/keywords/production","display_name":"Production (economics)","score":0.44341331720352173},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.4280874729156494},{"id":"https://openalex.org/keywords/convergence","display_name":"Convergence (economics)","score":0.4246594309806824},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.4102884829044342},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.38970234990119934},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.378146231174469},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3539917469024658},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.2987130880355835},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.23861825466156006},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.17982280254364014},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1783732771873474},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.0823623538017273}],"concepts":[{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.8261514902114868},{"id":"https://openalex.org/C167091322","wikidata":"https://www.wikidata.org/wiki/Q5463029","display_name":"Flux balance analysis","level":2,"score":0.7403213977813721},{"id":"https://openalex.org/C134121241","wikidata":"https://www.wikidata.org/wiki/Q899301","display_name":"Yield (engineering)","level":2,"score":0.5149974822998047},{"id":"https://openalex.org/C77957584","wikidata":"https://www.wikidata.org/wiki/Q1133550","display_name":"Gene knockout","level":3,"score":0.5019645690917969},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.4673497974872589},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.46361809968948364},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.44341331720352173},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.4280874729156494},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.4246594309806824},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.4102884829044342},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38970234990119934},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.378146231174469},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3539917469024658},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.2987130880355835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23861825466156006},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.17982280254364014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1783732771873474},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0823623538017273},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-37137-0_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-37137-0_12","pdf_url":null,"source":{"id":"https://openalex.org/S2764461748","display_name":"Studies in computational intelligence","issn_l":"1860-949X","issn":["1860-949X","1860-9503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Computational Intelligence","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6200000047683716}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W16088600","https://openalex.org/W112625174","https://openalex.org/W173438993","https://openalex.org/W1507811735","https://openalex.org/W1565928415","https://openalex.org/W1591310699","https://openalex.org/W1720617476","https://openalex.org/W1981045727","https://openalex.org/W2037425975","https://openalex.org/W2041715023","https://openalex.org/W2067469807","https://openalex.org/W2083401658","https://openalex.org/W2100818174","https://openalex.org/W2126175129","https://openalex.org/W2130364940","https://openalex.org/W2163240970","https://openalex.org/W4245225949","https://openalex.org/W7073855572"],"related_works":["https://openalex.org/W1999460937","https://openalex.org/W4297822179","https://openalex.org/W2077100702","https://openalex.org/W2606442043","https://openalex.org/W4240746025","https://openalex.org/W2171403356","https://openalex.org/W2377178523","https://openalex.org/W2420406980","https://openalex.org/W2046881622","https://openalex.org/W2046682534"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}