{"id":"https://openalex.org/W176561394","doi":"https://doi.org/10.1007/978-3-642-28839-5_28","title":"Computational Tools for Strain Optimization by Adding Reactions","display_name":"Computational Tools for Strain Optimization by Adding Reactions","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W176561394","doi":"https://doi.org/10.1007/978-3-642-28839-5_28","mag":"176561394"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-28839-5_28","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-28839-5_28","pdf_url":null,"source":{"id":"https://openalex.org/S4210208846","display_name":"Advances in intelligent and soft computing","issn_l":"1867-5662","issn":["1867-5662","1867-5670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Intelligent and Soft Computing","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://repositorium.uminho.pt/bitstreams/f47a2f9e-fec5-4274-85f2-897c26eaedc2/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081208807","display_name":"Sara Correia","orcid":"https://orcid.org/0000-0002-0395-5561"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Sara Correia","raw_affiliation_strings":["CCTC, University of Minho, Braga, Portugal","University of MInho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCTC, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"University of MInho","institution_ids":["https://openalex.org/I99682543"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040524717","display_name":"Miguel Rocha","orcid":"https://orcid.org/0000-0001-8439-8172"},"institutions":[{"id":"https://openalex.org/I99682543","display_name":"University of Minho","ror":"https://ror.org/037wpkx04","country_code":"PT","type":"education","lineage":["https://openalex.org/I99682543"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Miguel Rocha","raw_affiliation_strings":["CCTC, University of Minho, Braga, Portugal","University of MInho"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CCTC, University of Minho, Braga, Portugal","institution_ids":["https://openalex.org/I99682543"]},{"raw_affiliation_string":"University of MInho","institution_ids":["https://openalex.org/I99682543"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5081208807"],"corresponding_institution_ids":["https://openalex.org/I99682543"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05918339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"241","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10171","display_name":"Biofuel production and bioconversion","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simulated-annealing","display_name":"Simulated annealing","score":0.6765921115875244},{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.5294848084449768},{"id":"https://openalex.org/keywords/vanillin","display_name":"Vanillin","score":0.5282753109931946},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.5159283876419067},{"id":"https://openalex.org/keywords/metabolic-engineering","display_name":"Metabolic engineering","score":0.4750540256500244},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.45411208271980286},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4459470510482788},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.42732787132263184},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3174703121185303},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.2560691237449646},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22328180074691772},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.20237529277801514},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.16679108142852783},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1111910343170166}],"concepts":[{"id":"https://openalex.org/C126980161","wikidata":"https://www.wikidata.org/wiki/Q863783","display_name":"Simulated annealing","level":2,"score":0.6765921115875244},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.5294848084449768},{"id":"https://openalex.org/C2777340834","wikidata":"https://www.wikidata.org/wiki/Q33495","display_name":"Vanillin","level":2,"score":0.5282753109931946},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5159283876419067},{"id":"https://openalex.org/C6350086","wikidata":"https://www.wikidata.org/wiki/Q6822347","display_name":"Metabolic engineering","level":3,"score":0.4750540256500244},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45411208271980286},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4459470510482788},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.42732787132263184},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3174703121185303},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.2560691237449646},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22328180074691772},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.20237529277801514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16679108142852783},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1111910343170166},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/978-3-642-28839-5_28","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-28839-5_28","pdf_url":null,"source":{"id":"https://openalex.org/S4210208846","display_name":"Advances in intelligent and soft computing","issn_l":"1867-5662","issn":["1867-5662","1867-5670"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Intelligent and Soft Computing","raw_type":"book-chapter"},{"id":"pmh:oai:repositorium.uminho.pt:1822/23885","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/23885","pdf_url":"https://repositorium.uminho.pt/bitstreams/f47a2f9e-fec5-4274-85f2-897c26eaedc2/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference paper"},{"id":"pmh:oai:repositorium.sdum.uminho.pt:1822/23885","is_oa":true,"landing_page_url":"http://hdl.handle.net/1822/23885","pdf_url":null,"source":{"id":"https://openalex.org/S4306400354","display_name":"Reposit\u00f3riUM (Universidade do Minho)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I99682543","host_organization_name":"University of Minho","host_organization_lineage":["https://openalex.org/I99682543"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorium.uminho.pt:1822/23885","is_oa":true,"landing_page_url":"https://hdl.handle.net/1822/23885","pdf_url":"https://repositorium.uminho.pt/bitstreams/f47a2f9e-fec5-4274-85f2-897c26eaedc2/download","source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"conference paper"},"sustainable_development_goals":[{"score":0.5899999737739563,"id":"https://metadata.un.org/sdg/9","display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W176561394.pdf","grobid_xml":"https://content.openalex.org/works/W176561394.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1559956479","https://openalex.org/W1992306474","https://openalex.org/W2006672203","https://openalex.org/W2024060531","https://openalex.org/W2026089579","https://openalex.org/W2067469807","https://openalex.org/W2073837631","https://openalex.org/W2100818174","https://openalex.org/W2102164505","https://openalex.org/W2128746754","https://openalex.org/W2150908245","https://openalex.org/W2156409537","https://openalex.org/W4247892585"],"related_works":["https://openalex.org/W2302077272","https://openalex.org/W2208076193","https://openalex.org/W2334293709","https://openalex.org/W1881146916","https://openalex.org/W4310964874","https://openalex.org/W2023600884","https://openalex.org/W2273625928","https://openalex.org/W2930102738","https://openalex.org/W3116476418","https://openalex.org/W3092335715"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-05-22T09:01:20.584952","created_date":"2025-10-10T00:00:00"}