{"id":"https://openalex.org/W98077110","doi":"https://doi.org/10.1007/978-3-642-16345-6_22","title":"Reverse Engineering of Gene Regulation Networks with an Application to the DREAM4 in silico Network Challenge","display_name":"Reverse Engineering of Gene Regulation Networks with an Application to the DREAM4 in silico Network Challenge","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W98077110","doi":"https://doi.org/10.1007/978-3-642-16345-6_22","mag":"98077110"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-16345-6_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-16345-6_22","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Statistical Bioinformatics","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101891706","display_name":"Hyonho Chun","orcid":"https://orcid.org/0000-0002-7842-3316"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyonho Chun","raw_affiliation_strings":["Department of Epidemiology and Public Health, Yale University, New Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Public Health, Yale University, New Haven, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101822729","display_name":"Jia Kang","orcid":"https://orcid.org/0000-0002-3804-6640"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jia Kang","raw_affiliation_strings":["Program in Translational Informatics, Yale University, New Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Translational Informatics, Yale University, New Haven, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016089743","display_name":"Xianghua Zhang","orcid":"https://orcid.org/0000-0002-2180-6543"},"institutions":[{"id":"https://openalex.org/I126520041","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09","country_code":"CN","type":"education","lineage":["https://openalex.org/I126520041","https://openalex.org/I19820366"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianghua Zhang","raw_affiliation_strings":["Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, People\u2019s Republic of China","Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, People\u2019s Republic of China","institution_ids":["https://openalex.org/I126520041"]},{"raw_affiliation_string":"Department of Electronic Science and Technology, University of Science and Technology of China, Hefei, People's Republic of China","institution_ids":["https://openalex.org/I126520041"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101690048","display_name":"Minghua Deng","orcid":"https://orcid.org/0000-0002-2411-9650"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Minghua Deng","raw_affiliation_strings":["School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing, People\u2019s Republic of China","School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I20231570"]},{"raw_affiliation_string":"School of Mathematical Sciences and Center for Theoretical Biology, Peking University, Beijing, People's Republic of China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043651523","display_name":"Haisu Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haisu Ma","raw_affiliation_strings":["Program in Computational Biology, Yale University, New Haven, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Computational Biology, Yale University, New Haven, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074828414","display_name":"Hongyu Zhao","orcid":"https://orcid.org/0000-0003-1195-9607"},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hongyu Zhao","raw_affiliation_strings":["Department of Genetics, Yale University, New Haven, USA","School of Medicine, Dept. Epidemiology & Public Health, Yale University, College Street 60, New Haven, 06520, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics, Yale University, New Haven, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"School of Medicine, Dept. Epidemiology & Public Health, Yale University, College Street 60, New Haven, 06520, Connecticut, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074828414"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.4878,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.62063995,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"461","last_page":"477"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.8315680027008057},{"id":"https://openalex.org/keywords/reverse-engineering","display_name":"Reverse engineering","score":0.7374808192253113},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5954101085662842},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5601598620414734},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5518558025360107},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.46444064378738403},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4128817319869995},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34978020191192627},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3319287896156311},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2523092031478882},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.19225364923477173},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.15891361236572266},{"id":"https://openalex.org/keywords/systems-engineering","display_name":"Systems engineering","score":0.08742007613182068}],"concepts":[{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.8315680027008057},{"id":"https://openalex.org/C207850805","wikidata":"https://www.wikidata.org/wiki/Q269608","display_name":"Reverse engineering","level":2,"score":0.7374808192253113},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5954101085662842},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5601598620414734},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5518558025360107},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46444064378738403},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4128817319869995},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34978020191192627},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3319287896156311},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2523092031478882},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19225364923477173},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.15891361236572266},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.08742007613182068},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-642-16345-6_22","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-16345-6_22","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Handbook of Statistical Bioinformatics","raw_type":"book-chapter"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.173.7438","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.173.7438","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.stat.purdue.edu/calendar/seminars/vigre/docs/chun11-3-10.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W145994340","https://openalex.org/W603809537","https://openalex.org/W1502529406","https://openalex.org/W1514833568","https://openalex.org/W1530964327","https://openalex.org/W1575978816","https://openalex.org/W1581582023","https://openalex.org/W1607114662","https://openalex.org/W1792175597","https://openalex.org/W1892101717","https://openalex.org/W1893022572","https://openalex.org/W1969008680","https://openalex.org/W1971410477","https://openalex.org/W1990512452","https://openalex.org/W1992452843","https://openalex.org/W2000692739","https://openalex.org/W2001334414","https://openalex.org/W2006331688","https://openalex.org/W2010824638","https://openalex.org/W2023348596","https://openalex.org/W2033284638","https://openalex.org/W2041274449","https://openalex.org/W2046355391","https://openalex.org/W2049053063","https://openalex.org/W2053775054","https://openalex.org/W2056735347","https://openalex.org/W2059334100","https://openalex.org/W2061280979","https://openalex.org/W2065515536","https://openalex.org/W2065576510","https://openalex.org/W2076372398","https://openalex.org/W2086878253","https://openalex.org/W2087454975","https://openalex.org/W2103453943","https://openalex.org/W2111977130","https://openalex.org/W2112814716","https://openalex.org/W2114937915","https://openalex.org/W2117994680","https://openalex.org/W2120625059","https://openalex.org/W2121150592","https://openalex.org/W2122342005","https://openalex.org/W2125129404","https://openalex.org/W2125904845","https://openalex.org/W2127788692","https://openalex.org/W2129265801","https://openalex.org/W2135951244","https://openalex.org/W2136988691","https://openalex.org/W2137683543","https://openalex.org/W2141536144","https://openalex.org/W2146264532","https://openalex.org/W2148460690","https://openalex.org/W2151098983","https://openalex.org/W2154785870","https://openalex.org/W2155205047","https://openalex.org/W2157121418","https://openalex.org/W2163296115","https://openalex.org/W2163675212","https://openalex.org/W2164201990","https://openalex.org/W2279481061","https://openalex.org/W2522041912","https://openalex.org/W2611370172","https://openalex.org/W3098834468","https://openalex.org/W3099289621","https://openalex.org/W4212942074","https://openalex.org/W4235499294"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2363831530","https://openalex.org/W2101501829","https://openalex.org/W2003194288","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W391093122","https://openalex.org/W2106927126"],"abstract_inverted_index":null,"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}