{"id":"https://openalex.org/W20879212","doi":"https://doi.org/10.1007/978-3-642-15705-9_5","title":"Factor VIIa:TF induces activation of the JAK/STAT pathway; inflammatory signaling via non-inflammatory receptors","display_name":"Factor VIIa:TF induces activation of the JAK/STAT pathway; inflammatory signaling via non-inflammatory receptors","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W20879212","doi":"https://doi.org/10.1007/978-3-642-15705-9_5","mag":"20879212"},"language":"en","primary_location":{"id":"mag:20879212","is_oa":false,"landing_page_url":"http://dare.uva.nl/document/2/32841","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention","raw_type":null},"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044180782","display_name":"Henri H. Versteeg","orcid":"https://orcid.org/0000-0003-4294-175X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henri H. Versteeg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075427186","display_name":"Sjoukje H. Slofstra","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sjoukje H. Slofstra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071322217","display_name":"Dick J. Richer","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dick J. Richer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108770759","display_name":"Sander J. H. van Deventer","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sander J. H. van Deventer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069908102","display_name":"Maikel P. Peppelenbosch","orcid":"https://orcid.org/0000-0001-9112-6028"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maikel P. Peppelenbosch","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9112-6028","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":4.47e-05,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":"Pt 1","first_page":"37","last_page":"44"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11280","display_name":"Hemophilia Treatment and Research","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.6791030168533325},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.6539427042007446},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.5743929147720337},{"id":"https://openalex.org/keywords/tissue-factor","display_name":"Tissue factor","score":0.4949108958244324},{"id":"https://openalex.org/keywords/stat5","display_name":"STAT5","score":0.48564067482948303},{"id":"https://openalex.org/keywords/stat4","display_name":"STAT4","score":0.48112455010414124},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.46542924642562866},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4460311532020569},{"id":"https://openalex.org/keywords/transactivation","display_name":"Transactivation","score":0.428705632686615},{"id":"https://openalex.org/keywords/stat","display_name":"stat","score":0.42470160126686096},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.41170066595077515},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.39459139108657837},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.19868189096450806},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11736062169075012},{"id":"https://openalex.org/keywords/coagulation","display_name":"Coagulation","score":0.11455678939819336},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.09093418717384338},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.090512216091156}],"concepts":[{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.6791030168533325},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6539427042007446},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5743929147720337},{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.4949108958244324},{"id":"https://openalex.org/C2779391668","wikidata":"https://www.wikidata.org/wiki/Q4210018","display_name":"STAT5","level":3,"score":0.48564067482948303},{"id":"https://openalex.org/C65439459","wikidata":"https://www.wikidata.org/wiki/Q14914618","display_name":"STAT4","level":5,"score":0.48112455010414124},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.46542924642562866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4460311532020569},{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.428705632686615},{"id":"https://openalex.org/C2778277574","wikidata":"https://www.wikidata.org/wiki/Q665327","display_name":"stat","level":4,"score":0.42470160126686096},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41170066595077515},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39459139108657837},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19868189096450806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11736062169075012},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.11455678939819336},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.09093418717384338},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.090512216091156},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:20879212","is_oa":false,"landing_page_url":"http://dare.uva.nl/document/2/32841","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W9494736","https://openalex.org/W63837087","https://openalex.org/W1591377255","https://openalex.org/W1995387334","https://openalex.org/W2029539300","https://openalex.org/W2033726443","https://openalex.org/W2039265075","https://openalex.org/W2040495689","https://openalex.org/W2049567007","https://openalex.org/W2073129389","https://openalex.org/W2087144342","https://openalex.org/W2088375664","https://openalex.org/W2092097766","https://openalex.org/W2107691073","https://openalex.org/W2120056767","https://openalex.org/W2122601432","https://openalex.org/W2128839531","https://openalex.org/W2143760520","https://openalex.org/W2164143095","https://openalex.org/W2234822179","https://openalex.org/W2235373860","https://openalex.org/W2289234838","https://openalex.org/W2342851382","https://openalex.org/W2412312642"],"related_works":["https://openalex.org/W2071874640","https://openalex.org/W2088375664","https://openalex.org/W2117833357","https://openalex.org/W2090166013","https://openalex.org/W2768664330","https://openalex.org/W2136727466","https://openalex.org/W2107631090","https://openalex.org/W2101283727","https://openalex.org/W2000520554","https://openalex.org/W2126155653","https://openalex.org/W2094431180","https://openalex.org/W1967093416","https://openalex.org/W2091272253","https://openalex.org/W2070651101","https://openalex.org/W2066396134","https://openalex.org/W2947296782","https://openalex.org/W2142830561","https://openalex.org/W2071120706","https://openalex.org/W2027718658","https://openalex.org/W2094185828"],"abstract_inverted_index":{"In":[0],"this":[1,40,46],"paper,":[2],"we":[3],"propose":[4],"to":[5,59,67,83,110,122],"classify":[6],"medical":[7],"images":[8,19],"using":[9,26],"dissimilarities":[10],"computed":[11,90],"between":[12],"collections":[13],"of":[14,16,45,63,73,103],"regions":[15,65],"interest.":[17],"The":[18,42,78],"are":[20],"mapped":[21],"into":[22,115],"a":[23,32],"dissimilarity":[24,29],"space":[25],"an":[27,95,116],"image":[28,118],"measure,":[30],"and":[31,120],"standard":[33],"vector":[34],"space-based":[35],"classifier":[36],"is":[37,58,81,106],"applied":[38,82],"in":[39,51,75,89,127],"space.":[41],"classification":[43],"output":[44],"approach":[47,80],"can":[48],"be":[49],"used":[50],"computer":[52],"aided-diagnosis":[53],"problems":[54],"where":[55],"the":[56,61,69,98],"goal":[57],"detect":[60],"presence":[62],"abnormal":[64],"or":[66,71],"quantify":[68,84],"extent":[70],"severity":[72],"abnormalities":[74],"these":[76],"regions.":[77],"proposed":[79],"chronic":[85],"obstructive":[86],"pulmonary":[87,128],"disease":[88],"tomography":[91],"(CT)":[92],"images,":[93],"achieving":[94],"area":[96],"under":[97],"receiver":[99],"operating":[100],"characteristic":[101],"curve":[102],"0.817.":[104],"This":[105],"significantly":[107],"better":[108],"compared":[109,121],"combining":[111],"individual":[112],"region":[113],"classifications":[114],"overall":[117],"classification,":[119],"common":[123],"computerized":[124],"quantitative":[125],"measures":[126],"CT.":[129]},"counts_by_year":[],"updated_date":"2026-06-16T09:24:06.705377","created_date":"2016-06-24T00:00:00"}