{"id":"https://openalex.org/W62790187","doi":"https://doi.org/10.1007/978-3-322-83092-0_3","title":"Cluster Analysis of Multiparametric MR Imaging including ADC Maps and Relaxometry for Spatially High-Resolved Differentiation of Healthy and Ischemic Human Brain Tissue","display_name":"Cluster Analysis of Multiparametric MR Imaging including ADC Maps and Relaxometry for Spatially High-Resolved Differentiation of Healthy and Ischemic Human Brain Tissue","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W62790187","doi":"https://doi.org/10.1007/978-3-322-83092-0_3","mag":"62790187"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-322-83092-0_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-322-83092-0_3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Mathematik, insbesondere Informatik","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000840994","display_name":"Johannes Bernarding","orcid":"https://orcid.org/0000-0001-6429-4851"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Johannes Bernarding","raw_affiliation_strings":["Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068391541","display_name":"J\u00fcrgen Braun","orcid":"https://orcid.org/0000-0001-5183-7546"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00fcrgen Braun","raw_affiliation_strings":["Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003914998","display_name":"Joachim Hohmann","orcid":"https://orcid.org/0000-0003-2895-8774"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Hohmann","raw_affiliation_strings":["Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078777310","display_name":"Mathias Hoehn\u2010Berlage","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110850","display_name":"Max Planck Institute for Metabolism Research","ror":"https://ror.org/0199g0r92","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210110850"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mathias Hoehn-Berlage","raw_affiliation_strings":["Max-Planck-Institute for Neurological Research, Cologne  Germany"],"affiliations":[{"raw_affiliation_string":"Max-Planck-Institute for Neurological Research, Cologne  Germany","institution_ids":["https://openalex.org/I4210110850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076052737","display_name":"Christian Stapf","orcid":"https://orcid.org/0000-0002-3193-1006"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Stapf","raw_affiliation_strings":["Neurology (Stroke Unit), University Hospital Benjamin Franklin, Free University of Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Neurology (Stroke Unit), University Hospital Benjamin Franklin, Free University of Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039558486","display_name":"Klaus-J\u00fcrgen Wolf","orcid":null},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus-J\u00fcrgen Wolf","raw_affiliation_strings":["Radiology and Nuclear Medicine, University Hospital Benjamin Franklin, Free University of Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Radiology and Nuclear Medicine, University Hospital Benjamin Franklin, Free University of Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021975616","display_name":"Thomas Tolxdorff","orcid":"https://orcid.org/0000-0002-8612-8157"},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Tolxdorff","raw_affiliation_strings":["Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Departments of Medical Informatics, University Hospital Benjamin Franklin, Free University of Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5000840994"],"corresponding_institution_ids":["https://openalex.org/I75951250"],"apc_list":null,"apc_paid":null,"fwci":2.0187,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.84370861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"15","last_page":"34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.7158933877944946},{"id":"https://openalex.org/keywords/effective-diffusion-coefficient","display_name":"Effective diffusion coefficient","score":0.6776138544082642},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.6553851366043091},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.559363842010498},{"id":"https://openalex.org/keywords/relaxometry","display_name":"Relaxometry","score":0.5585475564002991},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"Multiparametric MRI","score":0.46014532446861267},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4233365058898926},{"id":"https://openalex.org/keywords/diffusion-imaging","display_name":"Diffusion imaging","score":0.4156113862991333},{"id":"https://openalex.org/keywords/brain-tissue","display_name":"Brain tissue","score":0.41167527437210083},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.3894152343273163},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.2946726679801941},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.23070591688156128},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.14388254284858704}],"concepts":[{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.7158933877944946},{"id":"https://openalex.org/C70816921","wikidata":"https://www.wikidata.org/wiki/Q258852","display_name":"Effective diffusion coefficient","level":3,"score":0.6776138544082642},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.6553851366043091},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.559363842010498},{"id":"https://openalex.org/C73286259","wikidata":"https://www.wikidata.org/wiki/Q7310885","display_name":"Relaxometry","level":4,"score":0.5585475564002991},{"id":"https://openalex.org/C2910607126","wikidata":"https://www.wikidata.org/wiki/Q48790829","display_name":"Multiparametric MRI","level":4,"score":0.46014532446861267},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4233365058898926},{"id":"https://openalex.org/C2992283565","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion imaging","level":4,"score":0.4156113862991333},{"id":"https://openalex.org/C2986936838","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Brain tissue","level":2,"score":0.41167527437210083},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3894152343273163},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.2946726679801941},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.23070591688156128},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.14388254284858704},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C83042744","wikidata":"https://www.wikidata.org/wiki/Q904043","display_name":"Spin echo","level":3,"score":0.0},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-322-83092-0_3","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-322-83092-0_3","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Mathematik, insbesondere Informatik","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6700000166893005,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W92741922","https://openalex.org/W973275982","https://openalex.org/W1212249228","https://openalex.org/W1965498242","https://openalex.org/W1970152228","https://openalex.org/W1970231623","https://openalex.org/W1972190491","https://openalex.org/W1973139765","https://openalex.org/W1991677258","https://openalex.org/W1995984027","https://openalex.org/W1996426651","https://openalex.org/W1999348312","https://openalex.org/W2001672324","https://openalex.org/W2006462636","https://openalex.org/W2011435635","https://openalex.org/W2016294888","https://openalex.org/W2016494060","https://openalex.org/W2024298641","https://openalex.org/W2025172432","https://openalex.org/W2032503729","https://openalex.org/W2040802078","https://openalex.org/W2043151182","https://openalex.org/W2043858070","https://openalex.org/W2044573796","https://openalex.org/W2047966126","https://openalex.org/W2053672964","https://openalex.org/W2054291866","https://openalex.org/W2063819516","https://openalex.org/W2064045922","https://openalex.org/W2076060467","https://openalex.org/W2081095120","https://openalex.org/W2083835881","https://openalex.org/W2084761689","https://openalex.org/W2084944797","https://openalex.org/W2091390349","https://openalex.org/W2092816355","https://openalex.org/W2092962006","https://openalex.org/W2093712031","https://openalex.org/W2095285055","https://openalex.org/W2098748526","https://openalex.org/W2109411133","https://openalex.org/W2129841144","https://openalex.org/W2133179125","https://openalex.org/W2156267331","https://openalex.org/W2158495596","https://openalex.org/W2159314344","https://openalex.org/W2168966309","https://openalex.org/W2466209577","https://openalex.org/W2475526632","https://openalex.org/W6605301741"],"related_works":["https://openalex.org/W2839837432","https://openalex.org/W2183164637","https://openalex.org/W2168966309","https://openalex.org/W2067830314","https://openalex.org/W2154231323","https://openalex.org/W2107154603","https://openalex.org/W3029613120","https://openalex.org/W4233912066","https://openalex.org/W2115784655","https://openalex.org/W4283699765"],"abstract_inverted_index":{"In":[0],"experimental":[1,62],"stroke":[2],"models":[3],"and":[4,84,101,107,126,130,147,151,158,175],"ischemic":[5,69,177,205],"human":[6,54,72,87,204],"brain":[7,55,73,88,162],"tissue":[8,149,163],"the":[9,16,27,32,39,51,59,85,143,152,171,197,200],"apparent":[10],"diffusion":[11],"coefficient":[12],"(ADC)":[13],"decreases":[14],"in":[15,26,71,112,170],"acute":[17],"phase,":[18],"may":[19,24,34],"normalize":[20],"after":[21],"reperfusion":[22],"or":[23,78,185,211],"increase":[25],"chronic":[28,176],"stage,":[29],"suggesting":[30],"that":[31,195],"ADC":[33,52,94,108,189,202],"be":[35],"used":[36],"to":[37,91],"monitor":[38],"physiologic":[40],"state":[41],"of":[42,50,61,99,121,145,154,203],"affected":[43],"tissue.":[44],"However,":[45],"a":[46,65,113,117],"spatially":[47],"high-resolved":[48],"determination":[49,153],"for":[53,58],"tissue,":[56],"required":[57],"transfer":[60],"results,":[63],"is":[64,207],"complex":[66,86],"task:":[67],"(a)":[68],"regions":[70,178,206],"are":[74],"often":[75],"small,":[76],"heterogeneous":[77],"irregularly":[79],"shaped;":[80],"(b)":[81],"examination":[82],"conditions":[83],"anatomy":[89],"lead":[90],"widely":[92],"scattered":[93],"values.":[95,214],"To":[96],"improve":[97],"characterization":[98],"healthy":[100,146],"pathologic":[102],"tissues,":[103],"navigated":[104],"diffusion-weighted":[105,186],"images":[106,187],"maps":[109],"were":[110,136,179],"incorporated":[111],"new":[114],"approach":[115],"into":[116],"multidimensional":[118],"parameter":[119],"set":[120],"relaxation":[122,169],"times":[123],"(T1,":[124],"T2)":[125],"T1-/T2-weighted":[127],"images.":[128],"Volunteers":[129],"patients":[131],"with":[132,188],"different":[133],"neurologic":[134],"deficits":[135],"examined.":[137],"A":[138],"supervised":[139],"histogram-based":[140],"analysis":[141],"enabled":[142],"segmentation":[144],"pathologie":[148],"classes":[150],"their":[155],"mean":[156,201],"values":[157],"standard":[159],"deviations.":[160],"Healthy":[161],"was":[164],"segmented":[165],"by":[166,182],"incorporating":[167],"T1":[168],"data":[172],"set.":[173],"Acute":[174],"best":[180],"differentiated":[181],"combining":[183],"T2-":[184],"maps.":[190],"The":[191],"results":[192],"support":[193],"findings":[194],"within":[196],"first":[198],"week":[199],"reduced":[208],"before":[209],"approaching":[210],"exceeding":[212],"normal":[213]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}