{"id":"https://openalex.org/W2606550833","doi":"https://doi.org/10.1007/978-3-319-57711-1_12","title":"Linking Alterations in Metabolic Fluxes with Shifts in Metabolite Levels by Means of Kinetic Modeling","display_name":"Linking Alterations in Metabolic Fluxes with Shifts in Metabolite Levels by Means of Kinetic Modeling","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2606550833","doi":"https://doi.org/10.1007/978-3-319-57711-1_12","mag":"2606550833"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-57711-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-57711-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S2764900261","display_name":"Communications in computer and information science","issn_l":"1865-0929","issn":["1865-0929","1865-0937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications in Computer and Information Science","raw_type":"book-chapter"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049497722","display_name":"Chiara Damiani","orcid":"https://orcid.org/0000-0002-5742-8302"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Chiara Damiani","raw_affiliation_strings":["Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Viale Sarca 336, 20126, Milan, Italy","SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","SYSBIO Centre of Systems Biology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Viale Sarca 336, 20126, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026873442","display_name":"Riccardo Colombo","orcid":"https://orcid.org/0000-0002-9499-0126"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Colombo","raw_affiliation_strings":["Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Viale Sarca 336, 20126, Milan, Italy","SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","SYSBIO Centre of Systems Biology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Viale Sarca 336, 20126, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037716718","display_name":"Marzia Di Filippo","orcid":"https://orcid.org/0000-0002-7428-0522"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzia Di Filippo","raw_affiliation_strings":["Dipartimento di Biotecnologie e Bioscienze, Universit\u00e0 degli Studi di Milano-Bicocca, Piazza della Scienza 2, 20126, Milan, Italy","SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","Dipartimento di Biotecnologie e Bioscienze, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","SYSBIO Centre of Systems Biology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Biotecnologie e Bioscienze, Universit\u00e0 degli Studi di Milano-Bicocca, Piazza della Scienza 2, 20126, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Biotecnologie e Bioscienze, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Milan, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065568541","display_name":"Dario Pescini","orcid":"https://orcid.org/0000-0002-3090-4823"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Dario Pescini","raw_affiliation_strings":["Dipartimento di Statistica e Metodi Quantitativi, Universit\u00e0 degli Studi di Milano-Bicocca, Via Bicocca degli Arcimboldi 8, 20126, Milan, Italy","SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","Dipartimento di Statistica e Metodi Quantitativi, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","SYSBIO Centre of Systems Biology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Statistica e Metodi Quantitativi, Universit\u00e0 degli Studi di Milano-Bicocca, Via Bicocca degli Arcimboldi 8, 20126, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Statistica e Metodi Quantitativi, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Milan, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073163964","display_name":"Giancarlo Mauri","orcid":"https://orcid.org/0000-0003-3520-4022"},"institutions":[{"id":"https://openalex.org/I66752286","display_name":"University of Milano-Bicocca","ror":"https://ror.org/01ynf4891","country_code":"IT","type":"education","lineage":["https://openalex.org/I66752286"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Mauri","raw_affiliation_strings":["Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Viale Sarca 336, 20126, Milan, Italy","SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","SYSBIO Centre of Systems Biology, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Viale Sarca 336, 20126, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Piazza della Scienza 2, 20126, Milan, Italy","institution_ids":[]},{"raw_affiliation_string":"Dipartimento di Informatica, Sistemistica e Comunicazione, Universit\u00e0 degli Studi di Milano-Bicocca, Milan, Italy","institution_ids":["https://openalex.org/I66752286"]},{"raw_affiliation_string":"SYSBIO Centre of Systems Biology, Milan, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049497722"],"corresponding_institution_ids":["https://openalex.org/I66752286"],"apc_list":null,"apc_paid":null,"fwci":3.6006,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.91337149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":null,"issue":null,"first_page":"138","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9768000245094299,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13539","display_name":"thermodynamics and calorimetric analyses","score":0.9661999940872192,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metabolite","display_name":"Metabolite","score":0.7738900780677795},{"id":"https://openalex.org/keywords/kinetic-energy","display_name":"Kinetic energy","score":0.6804395914077759},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.39798182249069214},{"id":"https://openalex.org/keywords/environmental-chemistry","display_name":"Environmental chemistry","score":0.3301306962966919},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.24648714065551758},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22976449131965637}],"concepts":[{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.7738900780677795},{"id":"https://openalex.org/C135889238","wikidata":"https://www.wikidata.org/wiki/Q46276","display_name":"Kinetic energy","level":2,"score":0.6804395914077759},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39798182249069214},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.3301306962966919},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24648714065551758},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22976449131965637},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-319-57711-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-57711-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S2764900261","display_name":"Communications in computer and information science","issn_l":"1865-0929","issn":["1865-0929","1865-0937"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications in Computer and Information Science","raw_type":"book-chapter"},{"id":"pmh:oai:boa.unimib.it:10281/151793","is_oa":false,"landing_page_url":"https://link.springer.com/chapter/10.1007/978-3-319-57711-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306401259","display_name":"BOA (University of Milano-Bicocca)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I66752286","host_organization_name":"University of Milano-Bicocca","host_organization_lineage":["https://openalex.org/I66752286"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/conferenceObject"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2016140326","https://openalex.org/W2018187409","https://openalex.org/W2038778951","https://openalex.org/W2051959027","https://openalex.org/W2061959260","https://openalex.org/W2062090250","https://openalex.org/W2075058338","https://openalex.org/W2108195113","https://openalex.org/W2124653577","https://openalex.org/W2148044817","https://openalex.org/W2149741353","https://openalex.org/W2152873168","https://openalex.org/W2156382259","https://openalex.org/W2302302500","https://openalex.org/W2762931393","https://openalex.org/W2764228816"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834","https://openalex.org/W657579294"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}