{"id":"https://openalex.org/W2603116877","doi":"https://doi.org/10.1007/978-3-319-56660-3_15","title":"Structure-Based Virtual Screening for Novel Modulators of Human Orexin 2 Receptor with Cloud Systems and Supercomputers","display_name":"Structure-Based Virtual Screening for Novel Modulators of Human Orexin 2 Receptor with Cloud Systems and Supercomputers","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2603116877","doi":"https://doi.org/10.1007/978-3-319-56660-3_15","mag":"2603116877"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-56660-3_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-56660-3_15","pdf_url":null,"source":{"id":"https://openalex.org/S2764461748","display_name":"Studies in computational intelligence","issn_l":"1860-949X","issn":["1860-949X","1860-9503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Computational Intelligence","raw_type":"book-chapter"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026816800","display_name":"Rafael Dole\u017eal","orcid":"https://orcid.org/0000-0001-9495-3934"},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I4210137570"]},{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Rafael Dolezal","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]},{"raw_affiliation_string":"Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013987157","display_name":"Eugenie Nepovimov\u00e1","orcid":"https://orcid.org/0000-0003-0281-246X"},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I4210137570"]},{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Eugenie Nepovimova","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]},{"raw_affiliation_string":"Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039230927","display_name":"Michaela Mel\u00edkov\u00e1","orcid":"https://orcid.org/0000-0001-8658-6169"},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I4210137570"]},{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Michaela Melikova","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]},{"raw_affiliation_string":"Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066903927","display_name":"Kamil Ku\u010da","orcid":"https://orcid.org/0000-0001-9664-1109"},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I4210137570"]},{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Kamil Kuca","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]},{"raw_affiliation_string":"Faculty of Informatics and Management, Center for Basic and Applied Research, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kr\u00e1lov\u00e9, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026816800"],"corresponding_institution_ids":["https://openalex.org/I4210137570","https://openalex.org/I75092371"],"apc_list":null,"apc_paid":null,"fwci":0.6815,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58100775,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"161","last_page":"171"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10985","display_name":"Sleep and Wakefulness Research","score":0.9873999953269958,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9526000022888184,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/virtual-screening","display_name":"Virtual screening","score":0.8249309062957764},{"id":"https://openalex.org/keywords/narcolepsy","display_name":"Narcolepsy","score":0.6814589500427246},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5823268294334412},{"id":"https://openalex.org/keywords/cloud-computing","display_name":"Cloud computing","score":0.5376120805740356},{"id":"https://openalex.org/keywords/orexin","display_name":"Orexin","score":0.4616497755050659},{"id":"https://openalex.org/keywords/docking","display_name":"Docking (animal)","score":0.4572247564792633},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.3180026412010193},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3058357834815979},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.2855328321456909},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.2391153872013092},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.22082367539405823},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.17057880759239197},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.15883058309555054},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15754804015159607},{"id":"https://openalex.org/keywords/neuropeptide","display_name":"Neuropeptide","score":0.14997032284736633},{"id":"https://openalex.org/keywords/neurology","display_name":"Neurology","score":0.1279432475566864},{"id":"https://openalex.org/keywords/operating-system","display_name":"Operating system","score":0.10504487156867981}],"concepts":[{"id":"https://openalex.org/C103697762","wikidata":"https://www.wikidata.org/wiki/Q4112105","display_name":"Virtual screening","level":3,"score":0.8249309062957764},{"id":"https://openalex.org/C2779494582","wikidata":"https://www.wikidata.org/wiki/Q189561","display_name":"Narcolepsy","level":3,"score":0.6814589500427246},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5823268294334412},{"id":"https://openalex.org/C79974875","wikidata":"https://www.wikidata.org/wiki/Q483639","display_name":"Cloud computing","level":2,"score":0.5376120805740356},{"id":"https://openalex.org/C2779680196","wikidata":"https://www.wikidata.org/wiki/Q410857","display_name":"Orexin","level":4,"score":0.4616497755050659},{"id":"https://openalex.org/C41685203","wikidata":"https://www.wikidata.org/wiki/Q1974042","display_name":"Docking (animal)","level":2,"score":0.4572247564792633},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3180026412010193},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3058357834815979},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2855328321456909},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.2391153872013092},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22082367539405823},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17057880759239197},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.15883058309555054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15754804015159607},{"id":"https://openalex.org/C118303440","wikidata":"https://www.wikidata.org/wiki/Q419968","display_name":"Neuropeptide","level":3,"score":0.14997032284736633},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.1279432475566864},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.10504487156867981},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-319-56660-3_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-56660-3_15","pdf_url":null,"source":{"id":"https://openalex.org/S2764461748","display_name":"Studies in computational intelligence","issn_l":"1860-949X","issn":["1860-949X","1860-9503"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Studies in Computational Intelligence","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1497476952","https://openalex.org/W2004595546","https://openalex.org/W2021137848","https://openalex.org/W2041326852","https://openalex.org/W2061745280","https://openalex.org/W2078315934","https://openalex.org/W2096719700","https://openalex.org/W2098228975","https://openalex.org/W2104025214","https://openalex.org/W2112411768","https://openalex.org/W2295952321","https://openalex.org/W2395558553"],"related_works":["https://openalex.org/W2759155180","https://openalex.org/W4239938417","https://openalex.org/W103760963","https://openalex.org/W2055154971","https://openalex.org/W2113413798","https://openalex.org/W2026066776","https://openalex.org/W2035238683","https://openalex.org/W2016419546","https://openalex.org/W2062408203","https://openalex.org/W2036163096"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}