{"id":"https://openalex.org/W2477664781","doi":"https://doi.org/10.1007/978-3-319-46726-9_72","title":"Comprehensive Maximum Likelihood Estimation of Diffusion Compartment Models Towards Reliable Mapping of Brain Microstructure","display_name":"Comprehensive Maximum Likelihood Estimation of Diffusion Compartment Models Towards Reliable Mapping of Brain Microstructure","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2477664781","doi":"https://doi.org/10.1007/978-3-319-46726-9_72","mag":"2477664781"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-46726-9_72","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-46726-9_72","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-3-319-46726-9_72","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061958575","display_name":"Aymeric Stamm","orcid":"https://orcid.org/0000-0002-8725-3654"},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT","US"],"is_corresponding":true,"raw_author_name":"Aymeric Stamm","raw_affiliation_strings":["CRL, Harvard Medical School, Boston Children\u2019s Hospital, Boston, Massachusetts, USA","MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"CRL, Harvard Medical School, Boston Children\u2019s Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032667893","display_name":"Olivier Commowick","orcid":"https://orcid.org/0000-0001-7345-6752"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en sciences et technologies du num\u00e9rique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"government","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4387152452","display_name":"Empenn","ror":"https://ror.org/02hp31992","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1326498283","https://openalex.org/I154526488","https://openalex.org/I4387152452","https://openalex.org/I56067802"]},{"id":"https://openalex.org/I56067802","display_name":"Universit\u00e9 de Rennes","ror":"https://ror.org/015m7wh34","country_code":"FR","type":"education","lineage":["https://openalex.org/I56067802"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olivier Commowick","raw_affiliation_strings":["VISAGES, INSERM U746, CNRS UMR6074, INRIA, University of Rennes I, Rennes, France"],"affiliations":[{"raw_affiliation_string":"VISAGES, INSERM U746, CNRS UMR6074, INRIA, University of Rennes I, Rennes, France","institution_ids":["https://openalex.org/I56067802","https://openalex.org/I154526488","https://openalex.org/I1326498283","https://openalex.org/I1294671590","https://openalex.org/I4387152452"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054913205","display_name":"Simon K. Warfield","orcid":"https://orcid.org/0000-0002-7659-3880"},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon K. Warfield","raw_affiliation_strings":["CRL, Harvard Medical School, Boston Children\u2019s Hospital, Boston, Massachusetts, USA","CRL, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, USA"],"affiliations":[{"raw_affiliation_string":"CRL, Harvard Medical School, Boston Children\u2019s Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1288882113"]},{"raw_affiliation_string":"CRL, Harvard Medical School, Boston Children's Hospital, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004699501","display_name":"Simone Vantini","orcid":"https://orcid.org/0000-0001-8255-5306"},"institutions":[{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Vantini","raw_affiliation_strings":["MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy"],"affiliations":[{"raw_affiliation_string":"MOX, Department of Mathematics, Politecnico di Milano, Milan, Italy","institution_ids":["https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5061958575"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I93860229"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":{"value":5000,"currency":"EUR","value_usd":5392},"fwci":3.1947,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.9241517,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"622","last_page":"630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11885","display_name":"MRI in cancer diagnosis","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.9926000237464905,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.8473268747329712},{"id":"https://openalex.org/keywords/estimator","display_name":"Estimator","score":0.7850823998451233},{"id":"https://openalex.org/keywords/convergence","display_name":"Convergence (economics)","score":0.6086744666099548},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5801488161087036},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5303331613540649},{"id":"https://openalex.org/keywords/variance","display_name":"Variance (accounting)","score":0.5236603617668152},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.48603302240371704},{"id":"https://openalex.org/keywords/voxel","display_name":"Voxel","score":0.469498872756958},{"id":"https://openalex.org/keywords/variance-reduction","display_name":"Variance reduction","score":0.43517613410949707},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.42264100909233093},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4118475914001465},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.3677939176559448},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3156123757362366},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2284335494041443},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2049805223941803},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.13944029808044434},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13120537996292114},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.12599867582321167}],"concepts":[{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.8473268747329712},{"id":"https://openalex.org/C185429906","wikidata":"https://www.wikidata.org/wiki/Q1130160","display_name":"Estimator","level":2,"score":0.7850823998451233},{"id":"https://openalex.org/C2777303404","wikidata":"https://www.wikidata.org/wiki/Q759757","display_name":"Convergence (economics)","level":2,"score":0.6086744666099548},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5801488161087036},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5303331613540649},{"id":"https://openalex.org/C196083921","wikidata":"https://www.wikidata.org/wiki/Q7915758","display_name":"Variance (accounting)","level":2,"score":0.5236603617668152},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.48603302240371704},{"id":"https://openalex.org/C54170458","wikidata":"https://www.wikidata.org/wiki/Q663554","display_name":"Voxel","level":2,"score":0.469498872756958},{"id":"https://openalex.org/C62644790","wikidata":"https://www.wikidata.org/wiki/Q3454689","display_name":"Variance reduction","level":3,"score":0.43517613410949707},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.42264100909233093},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4118475914001465},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.3677939176559448},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3156123757362366},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2284335494041443},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2049805223941803},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.13944029808044434},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13120537996292114},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.12599867582321167},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C121955636","wikidata":"https://www.wikidata.org/wiki/Q4116214","display_name":"Accounting","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/978-3-319-46726-9_72","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-46726-9_72","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},{"id":"pmh:oai:HAL:inserm-01349556v1","is_oa":true,"landing_page_url":"https://inserm.hal.science/inserm-01349556","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"19th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), Oct 2016, Athens, Greece. pp.622 - 630, ⟨10.1007/978-3-319-46726-9_72⟩","raw_type":"Conference papers"},{"id":"pmh:oai:re.public.polimi.it:11311/1008129","is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/1008129","pdf_url":null,"source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/bookPart"}],"best_oa_location":{"id":"doi:10.1007/978-3-319-46726-9_72","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-46726-9_72","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1965170868","https://openalex.org/W2011015491","https://openalex.org/W2024729467","https://openalex.org/W2032254014","https://openalex.org/W2063761843","https://openalex.org/W2087070363","https://openalex.org/W2143752532","https://openalex.org/W2153245297","https://openalex.org/W2154524479","https://openalex.org/W2155382668"],"related_works":["https://openalex.org/W3122602933","https://openalex.org/W2950038056","https://openalex.org/W1544940847","https://openalex.org/W2289285490","https://openalex.org/W3031816500","https://openalex.org/W2298254442","https://openalex.org/W2169367269","https://openalex.org/W1977112355","https://openalex.org/W2900543860","https://openalex.org/W2980964960"],"abstract_inverted_index":{"Diffusion":[0,30],"MRI":[1],"is":[2,43,164],"a":[3,47,115],"key":[4,83],"in-vivo":[5],"non":[6],"invasive":[7],"imaging":[8],"capability":[9],"that":[10,58,121],"can":[11],"probe":[12],"the":[13,16,28,35,65,70,125,138,153,173],"microstructure":[14,90,146],"of":[15,27,55,63,88,97,109,134,172],"brain.":[17],"However,":[18],"its":[19],"limited":[20],"resolution":[21],"requires":[22],"complex":[23,151],"voxelwise":[24],"generative":[25],"models":[26,33,57,169],"diffusion.":[29],"Compartment":[31],"(DC)":[32],"divide":[34],"voxel":[36],"into":[37],"smaller":[38],"compartments":[39],"in":[40,128,148],"which":[41],"diffusion":[42],"homogeneous.":[44],"We":[45,100],"present":[46],"comprehensive":[48],"framework":[49,158],"for":[50,167],"maximum":[51],"likelihood":[52],"estimation":[53],"(MLE)":[54],"such":[56],"jointly":[59],"features":[60],"ML":[61,80,157],"estimators":[62,81,136],"(i)":[64],"baseline":[66],"MR":[67],"signal,":[68],"(ii)":[69],"noise":[71],"variance,":[72],"(iii)":[73],"compartment":[74],"proportions,":[75],"and":[76,96,114,163],"(iv)":[77],"diffusion-related":[78],"parameters.":[79],"are":[82,93],"to":[84,111,137],"providing":[85],"reliable":[86,145],"mapping":[87,147],"brain":[89],"as":[91,150,152,170],"they":[92],"asymptotically":[94],"unbiased":[95],"minimal":[98],"variance.":[99],"compare":[101],"our":[102,122],"algorithm":[103],"(which":[104],"efficiently":[105],"exploits":[106],"analytical":[107],"properties":[108],"MLE)":[110],"alternative":[112],"implementations":[113],"state-of-the-art":[116],"strategy.":[117],"Simulation":[118],"results":[119,141],"show":[120],"approach":[123],"offers":[124],"best":[126],"reduction":[127],"computational":[129],"burden":[130],"while":[131],"guaranteeing":[132],"convergence":[133],"numerical":[135],"MLE.":[139],"In-vivo":[140],"also":[142],"reveal":[143],"remarkably":[144],"areas":[149],"centrum":[154],"semi-ovale.":[155],"Our":[156],"accommodates":[159],"any":[160],"DC":[161],"model":[162],"available":[165],"freely":[166],"multi-tensor":[168],"part":[171],"ANIMA":[174],"software":[175],"(":[176],"https://github.com/Inria-Visages/Anima-Public/wiki":[177],").":[178]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":1}],"updated_date":"2026-04-23T09:07:50.710637","created_date":"2025-10-10T00:00:00"}