{"id":"https://openalex.org/W2527045222","doi":"https://doi.org/10.1007/978-3-319-46726-9_47","title":"ASL-incorporated Pharmacokinetic Modelling of PET Data With Reduced Acquisition Time: Application to Amyloid Imaging","display_name":"ASL-incorporated Pharmacokinetic Modelling of PET Data With Reduced Acquisition Time: Application to Amyloid Imaging","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2527045222","doi":"https://doi.org/10.1007/978-3-319-46726-9_47","mag":"2527045222"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-46726-9_47","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-46726-9_47","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-3-319-46726-9_47","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064290628","display_name":"Catherine J Scott","orcid":"https://orcid.org/0000-0003-0129-738X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Catherine J. Scott","raw_affiliation_strings":["Translational Imaging Group, CMIC, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Imaging Group, CMIC, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014127274","display_name":"Jieqing Jiao","orcid":null},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jieqing Jiao","raw_affiliation_strings":["Translational Imaging Group, CMIC, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Imaging Group, CMIC, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035099926","display_name":"Andrew Melbourne","orcid":"https://orcid.org/0000-0001-7667-3947"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew Melbourne","raw_affiliation_strings":["Translational Imaging Group, CMIC, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Imaging Group, CMIC, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045615014","display_name":"Jonathan M. Schott","orcid":"https://orcid.org/0000-0003-2059-024X"},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jonathan M. Schott","raw_affiliation_strings":["Dementia Research Centre, Institute of Neurology, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Centre, Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016217712","display_name":"Brian F. Hutton","orcid":"https://orcid.org/0000-0001-7481-0952"},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["AU","GB"],"is_corresponding":false,"raw_author_name":"Brian F. Hutton","raw_affiliation_strings":["Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia","Institute of Nuclear Medicine, University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Medical Radiation Physics, University of Wollongong, Wollongong, New South Wales, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Institute of Nuclear Medicine, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082106258","display_name":"S\u00e9bastien Ourselin","orcid":"https://orcid.org/0000-0002-5694-5340"},"institutions":[{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"S\u00e9bastien Ourselin","raw_affiliation_strings":["Dementia Research Centre, Institute of Neurology, University College London, London, UK","Translational Imaging Group, CMIC, University College London, London, UK","University College London, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementia Research Centre, Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Translational Imaging Group, CMIC, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5064290628"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":{"value":5000,"currency":"EUR","value_usd":5392},"fwci":3.0738,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.92566372,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"406","last_page":"413"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/positron-emission-tomography","display_name":"Positron emission tomography","score":0.814092755317688},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5877653956413269},{"id":"https://openalex.org/keywords/arterial-spin-labeling","display_name":"Arterial spin labeling","score":0.5809973478317261},{"id":"https://openalex.org/keywords/blood-flow","display_name":"Blood flow","score":0.5474395155906677},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5283226370811462},{"id":"https://openalex.org/keywords/cerebral-blood-flow","display_name":"Cerebral blood flow","score":0.5222105383872986},{"id":"https://openalex.org/keywords/standardized-uptake-value","display_name":"Standardized uptake value","score":0.4762989580631256},{"id":"https://openalex.org/keywords/nuclear-medicine","display_name":"Nuclear medicine","score":0.4648963510990143},{"id":"https://openalex.org/keywords/pet-imaging","display_name":"Pet imaging","score":0.4562685191631317},{"id":"https://openalex.org/keywords/data-acquisition","display_name":"Data acquisition","score":0.42534321546554565},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.33324021100997925},{"id":"https://openalex.org/keywords/biomedical-engineering","display_name":"Biomedical engineering","score":0.3321830630302429},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.30224788188934326},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.19135984778404236},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.13771557807922363}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.814092755317688},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5877653956413269},{"id":"https://openalex.org/C3018723549","wikidata":"https://www.wikidata.org/wiki/Q56284158","display_name":"Arterial spin labeling","level":3,"score":0.5809973478317261},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.5474395155906677},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5283226370811462},{"id":"https://openalex.org/C157767197","wikidata":"https://www.wikidata.org/wiki/Q886843","display_name":"Cerebral blood flow","level":2,"score":0.5222105383872986},{"id":"https://openalex.org/C199374082","wikidata":"https://www.wikidata.org/wiki/Q907080","display_name":"Standardized uptake value","level":3,"score":0.4762989580631256},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4648963510990143},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.4562685191631317},{"id":"https://openalex.org/C163985040","wikidata":"https://www.wikidata.org/wiki/Q1172399","display_name":"Data acquisition","level":2,"score":0.42534321546554565},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.33324021100997925},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.3321830630302429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30224788188934326},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.19135984778404236},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13771557807922363},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1007/978-3-319-46726-9_47","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-46726-9_47","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},{"id":"pmh:oai:kclpure.kcl.ac.uk:openaire/16f89463-6d4b-49ae-93a1-0fa1c95dae5d","is_oa":true,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/16f89463-6d4b-49ae-93a1-0fa1c95dae5d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:ro.uow.edu.au:eispapers-7664","is_oa":false,"landing_page_url":"https://ro.uow.edu.au/eispapers/6632","pdf_url":null,"source":{"id":"https://openalex.org/S4306400510","display_name":"Research Online (University of Wollongong)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204824540","host_organization_name":"University of Wollongong","host_organization_lineage":["https://openalex.org/I204824540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty of Engineering and Information Sciences - Papers: Part A","raw_type":"article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:1530675","is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/1530675/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"In: Ourselin, S and Joskowicz, L and Sabuncu, MR and Unal, G and Wells, W, (eds.) MICCAI 2016: Medical Image Computing and Computer-Assisted Intervention: Proceedings, Part III. (pp. pp. 406-413). Springer International Publishing AG (2016)","raw_type":"Proceedings paper"},{"id":"pmh:oai:figshare.com:article/27756900","is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/ASL-incorporated_pharmacokinetic_modelling_of_PET_data_with_reduced_acquisition_time_Application_to_amyloid_imaging/27756900","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1007/978-3-319-46726-9_47","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-319-46726-9_47","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6800468499","display_name":null,"funder_award_id":"MR/J01107X/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1949599440","https://openalex.org/W1995321462","https://openalex.org/W2027668399","https://openalex.org/W2038018468","https://openalex.org/W2054422278","https://openalex.org/W2117671988","https://openalex.org/W2167720733","https://openalex.org/W2301387898"],"related_works":["https://openalex.org/W2070060620","https://openalex.org/W2691788872","https://openalex.org/W2040386745","https://openalex.org/W3213626221","https://openalex.org/W2557712647","https://openalex.org/W1939164019","https://openalex.org/W4309516704","https://openalex.org/W4233840641","https://openalex.org/W2355116690","https://openalex.org/W2132129501"],"abstract_inverted_index":{"Pharmacokinetic":[0],"analysis":[1],"of":[2,14,78,164],"Positron":[3],"Emission":[4],"Tomography":[5],"(PET)":[6],"data":[7,97,125,143,157],"typically":[8],"requires":[9],"at":[10],"least":[11],"one":[12],"hour":[13],"image":[15],"acquisition,":[16],"which":[17,133],"poses":[18],"a":[19,30,159],"great":[20],"disadvantage":[21],"in":[22,162],"clinical":[23,94],"practice.":[24],"In":[25],"this":[26],"work,":[27],"we":[28],"propose":[29],"novel":[31],"approach":[32,108],"for":[33],"pharmacokinetic":[34],"modelling":[35],"with":[36,88,109,136],"significantly":[37],"reduced":[38],"PET":[39,80,85,124,142],"acquisition":[40],"time,":[41],"by":[42,67],"incorporating":[43],"the":[44,70,79,106,110,137,152,156],"blood":[45,64],"flow":[46,90],"information":[47],"from":[48,74,98,120,139,155],"simultaneously":[49],"acquired":[50],"arterial":[51],"spin":[52],"labelling":[53],"(ASL)":[54],"magnetic":[55],"resonance":[56],"imaging":[57,96],"(MRI).":[58],"A":[59],"relationship":[60],"is":[61,134],"established":[62],"between":[63],"flow,":[65],"measured":[66],"ASL,":[68],"and":[69,126],"transfer":[71],"rate":[72],"constant":[73],"plasma":[75],"to":[76,83],"tissue":[77,113],"tracer,":[81],"leading":[82],"modified":[84],"kinetic":[86],"models":[87],"ASL-derived":[89],"information.":[91],"Evaluation":[92],"on":[93],"amyloid":[95,117,166],"an":[99],"Alzheimer\u2019s":[100],"disease":[101],"(AD)":[102],"study":[103],"shows":[104],"that":[105],"proposed":[107],"simplified":[111],"reference":[112],"model":[114],"can":[115],"achieve":[116],"burden":[118,167],"estimation":[119,138],"30":[121],"min":[122,128,141],"[$$^{18}$$F]florbetapir":[123],"5":[127],"simultaneous":[129],"ASL":[130],"MR":[131],"data,":[132],"comparable":[135],"60":[140],"(mean":[144,168],"error$$\\,=-0.03$$).":[145],"Conversely,":[146],"standardised":[147],"uptake":[148],"value":[149],"ratio":[150],"(SUVR),":[151],"alternative":[153],"measure":[154],"showed":[158],"positive":[160],"bias":[161],"areas":[163],"higher":[165],"error$$\\,=0.07$$).":[169]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
