{"id":"https://openalex.org/W2558114163","doi":"https://doi.org/10.1007/978-3-319-45246-3_26","title":"Designing QSAR Models for Promising TLR4 Agonists Isolated from Euodia Asteridula by Artificial Neural Networks Enhanced by Optimal Brain Surgeon","display_name":"Designing QSAR Models for Promising TLR4 Agonists Isolated from Euodia Asteridula by Artificial Neural Networks Enhanced by Optimal Brain Surgeon","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2558114163","doi":"https://doi.org/10.1007/978-3-319-45246-3_26","mag":"2558114163"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-319-45246-3_26","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-45246-3_26","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026816800","display_name":"Rafael Dole\u017eal","orcid":"https://orcid.org/0000-0001-9495-3934"},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I4210137570"]},{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":true,"raw_author_name":"Rafael Dolezal","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic","Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]},{"raw_affiliation_string":"Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054112795","display_name":"Jan Trejbal","orcid":"https://orcid.org/0000-0003-3059-9432"},"institutions":[{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Trejbal","raw_affiliation_strings":["Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044560055","display_name":"Jakub M\u011bs\u00ed\u010dek","orcid":"https://orcid.org/0000-0002-0438-721X"},"institutions":[{"id":"https://openalex.org/I4210137570","display_name":"University Hospital Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/04wckhb82","country_code":"CZ","type":"funder","lineage":["https://openalex.org/I4210137570"]},{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jakub Mesicek","raw_affiliation_strings":["Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic","Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Center, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I4210137570"]},{"raw_affiliation_string":"Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035914207","display_name":"Agata Milanov","orcid":null},"institutions":[{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Agata Milanov","raw_affiliation_strings":["Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025578676","display_name":"Veronika Ra\u010d\u00e1kov\u00e1","orcid":null},"institutions":[{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Veronika Racakova","raw_affiliation_strings":["Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000700030","display_name":"Ji\u0159\u00ed K\u0159enek","orcid":null},"institutions":[{"id":"https://openalex.org/I75092371","display_name":"University of Hradec Kr\u00e1lov\u00e9","ror":"https://ror.org/05k238v14","country_code":"CZ","type":"education","lineage":["https://openalex.org/I75092371"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jiri Krenek","raw_affiliation_strings":["Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic","institution_ids":["https://openalex.org/I75092371"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026816800"],"corresponding_institution_ids":["https://openalex.org/I4210137570","https://openalex.org/I75092371"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":2.2242,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.9005655,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"271","last_page":"281"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.9879000186920166,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13791","display_name":"Veterinary medicine and infectious diseases","score":0.9732999801635742,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13649","display_name":"Advanced Synthetic Organic Chemistry","score":0.970300018787384,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-structure\u2013activity-relationship","display_name":"Quantitative structure\u2013activity relationship","score":0.8098145723342896},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7358954548835754},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.7138831615447998},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6319550275802612},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5514073967933655},{"id":"https://openalex.org/keywords/backpropagation","display_name":"Backpropagation","score":0.4817224144935608}],"concepts":[{"id":"https://openalex.org/C164126121","wikidata":"https://www.wikidata.org/wiki/Q766383","display_name":"Quantitative structure\u2013activity relationship","level":2,"score":0.8098145723342896},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7358954548835754},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.7138831615447998},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6319550275802612},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5514073967933655},{"id":"https://openalex.org/C155032097","wikidata":"https://www.wikidata.org/wiki/Q798503","display_name":"Backpropagation","level":3,"score":0.4817224144935608}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-319-45246-3_26","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-319-45246-3_26","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1588337522","https://openalex.org/W1970853727","https://openalex.org/W1981399181","https://openalex.org/W2057295660","https://openalex.org/W2102927413","https://openalex.org/W2104025214","https://openalex.org/W2114766824","https://openalex.org/W2125389748","https://openalex.org/W2144629150","https://openalex.org/W2156150815"],"related_works":["https://openalex.org/W2894173309","https://openalex.org/W4387932263","https://openalex.org/W2098962763","https://openalex.org/W2961085424","https://openalex.org/W2371065793","https://openalex.org/W2157746493","https://openalex.org/W4306674287","https://openalex.org/W1977222966","https://openalex.org/W3046775127","https://openalex.org/W3107602296"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-05-05T08:41:31.759640","created_date":"2025-10-10T00:00:00"}