{"id":"https://openalex.org/W4416309873","doi":"https://doi.org/10.1007/978-3-032-08455-2_23","title":"Regulating Toxic Amyloid-Beta Oligomers in\u00a0Alzheimer\u2019s Disease: A Control Theory Approach","display_name":"Regulating Toxic Amyloid-Beta Oligomers in\u00a0Alzheimer\u2019s Disease: A Control Theory Approach","publication_year":2025,"publication_date":"2025-11-18","ids":{"openalex":"https://openalex.org/W4416309873","doi":"https://doi.org/10.1007/978-3-032-08455-2_23"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-032-08455-2_23","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-032-08455-2_23","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079401465","display_name":"Swadesh Pal","orcid":"https://orcid.org/0000-0002-6873-7338"},"institutions":[{"id":"https://openalex.org/I75381157","display_name":"Wilfrid Laurier University","ror":"https://ror.org/00fn7gb05","country_code":"CA","type":"education","lineage":["https://openalex.org/I75381157"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Swadesh Pal","raw_affiliation_strings":["M3AI Laboratory, MS2Discovery Interdisciplinary Research Institute, Wilfrid Laurier University, Waterloo, ON, N2L 3C5, Canada"],"raw_orcid":"https://orcid.org/0000-0002-6873-7338","affiliations":[{"raw_affiliation_string":"M3AI Laboratory, MS2Discovery Interdisciplinary Research Institute, Wilfrid Laurier University, Waterloo, ON, N2L 3C5, Canada","institution_ids":["https://openalex.org/I75381157"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045989726","display_name":"Roderick Melnik","orcid":"https://orcid.org/0000-0002-1560-6684"},"institutions":[{"id":"https://openalex.org/I2802176441","display_name":"Basque Center for Applied Mathematics","ror":"https://ror.org/03b21sh32","country_code":"ES","type":"education","lineage":["https://openalex.org/I2802176441"]},{"id":"https://openalex.org/I75381157","display_name":"Wilfrid Laurier University","ror":"https://ror.org/00fn7gb05","country_code":"CA","type":"education","lineage":["https://openalex.org/I75381157"]}],"countries":["CA","ES"],"is_corresponding":true,"raw_author_name":"Roderick Melnik","raw_affiliation_strings":["BCAM - Basque Center for Applied Mathematics, E-48009, Bilbao, Spain","M3AI Laboratory, MS2Discovery Interdisciplinary Research Institute, Wilfrid Laurier University, Waterloo, ON, N2L 3C5, Canada"],"raw_orcid":"https://orcid.org/0000-0002-1560-6684","affiliations":[{"raw_affiliation_string":"BCAM - Basque Center for Applied Mathematics, E-48009, Bilbao, Spain","institution_ids":["https://openalex.org/I2802176441"]},{"raw_affiliation_string":"M3AI Laboratory, MS2Discovery Interdisciplinary Research Institute, Wilfrid Laurier University, Waterloo, ON, N2L 3C5, Canada","institution_ids":["https://openalex.org/I75381157"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045989726"],"corresponding_institution_ids":["https://openalex.org/I2802176441","https://openalex.org/I75381157"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.6780229,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"301","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6389999985694885,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.6389999985694885,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11829","display_name":"Mathematical Biology Tumor Growth","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.03689999878406525,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/optimal-control","display_name":"Optimal control","score":0.511900007724762},{"id":"https://openalex.org/keywords/control","display_name":"Control (management)","score":0.45980000495910645},{"id":"https://openalex.org/keywords/probability-density-function","display_name":"Probability density function","score":0.45730000734329224},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.43970000743865967},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.43230000138282776},{"id":"https://openalex.org/keywords/dimer","display_name":"Dimer","score":0.43050000071525574}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7311999797821045},{"id":"https://openalex.org/C91575142","wikidata":"https://www.wikidata.org/wiki/Q1971426","display_name":"Optimal control","level":2,"score":0.511900007724762},{"id":"https://openalex.org/C2775924081","wikidata":"https://www.wikidata.org/wiki/Q55608371","display_name":"Control (management)","level":2,"score":0.45980000495910645},{"id":"https://openalex.org/C197055811","wikidata":"https://www.wikidata.org/wiki/Q207522","display_name":"Probability density function","level":2,"score":0.45730000734329224},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.4410000145435333},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.43970000743865967},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.43230000138282776},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.43050000071525574},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.38960000872612},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.3668000102043152},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.3546000123023987},{"id":"https://openalex.org/C8272713","wikidata":"https://www.wikidata.org/wiki/Q176737","display_name":"Stochastic process","level":2,"score":0.31769999861717224},{"id":"https://openalex.org/C47446073","wikidata":"https://www.wikidata.org/wiki/Q5165890","display_name":"Control theory (sociology)","level":3,"score":0.31369999051094055},{"id":"https://openalex.org/C17500928","wikidata":"https://www.wikidata.org/wiki/Q959968","display_name":"Control system","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C170131372","wikidata":"https://www.wikidata.org/wiki/Q7617811","display_name":"Stochastic control","level":3,"score":0.2888999879360199}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-032-08455-2_23","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-032-08455-2_23","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W231975775","https://openalex.org/W304622482","https://openalex.org/W1605885548","https://openalex.org/W1965219278","https://openalex.org/W1989996110","https://openalex.org/W2063917507","https://openalex.org/W2067088461","https://openalex.org/W2527645962","https://openalex.org/W2789555777","https://openalex.org/W2969535869","https://openalex.org/W3080820931","https://openalex.org/W3088454151","https://openalex.org/W3134680770","https://openalex.org/W3198052269","https://openalex.org/W4234903469","https://openalex.org/W4294295443","https://openalex.org/W4361213733","https://openalex.org/W4384161995","https://openalex.org/W4395686010"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-06-13T06:13:01.061226","created_date":"2025-11-18T00:00:00"}