{"id":"https://openalex.org/W4416237887","doi":"https://doi.org/10.1007/978-3-032-08452-1_15","title":"IGHV Mutational Status and DNA Entropy: Refining Prognostic Tools in Chronic Lymphocytic Leukemia","display_name":"IGHV Mutational Status and DNA Entropy: Refining Prognostic Tools in Chronic Lymphocytic Leukemia","publication_year":2025,"publication_date":"2025-11-15","ids":{"openalex":"https://openalex.org/W4416237887","doi":"https://doi.org/10.1007/978-3-032-08452-1_15"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-032-08452-1_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-032-08452-1_15","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023037777","display_name":"\u0410. \u0412. \u041c\u0430\u0440\u0442\u044b\u043d\u0435\u043d\u043a\u043e","orcid":"https://orcid.org/0000-0002-0609-2220"},"institutions":[{"id":"https://openalex.org/I8765205","display_name":"V. N. Karazin Kharkiv National University","ror":"https://ror.org/03ftejk10","country_code":"UA","type":"education","lineage":["https://openalex.org/I8765205"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES","UA"],"is_corresponding":true,"raw_author_name":"Alexander Martynenko","raw_affiliation_strings":["University of Barcelona, 08007, Barcelona, Spain","V. N. Karazin Kharkiv National University, Kharkiv, 61022, Ukraine"],"affiliations":[{"raw_affiliation_string":"University of Barcelona, 08007, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]},{"raw_affiliation_string":"V. N. Karazin Kharkiv National University, Kharkiv, 61022, Ukraine","institution_ids":["https://openalex.org/I8765205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027556349","display_name":"Xavier Pastor","orcid":"https://orcid.org/0000-0001-8267-7151"},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xavier Pastor","raw_affiliation_strings":["Hospital Clinic of Barcelona, 08036, Barcelona, Spain","University of Barcelona, 08007, Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Clinic of Barcelona, 08036, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"University of Barcelona, 08007, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058642542","display_name":"Santiago Frid","orcid":"https://orcid.org/0000-0001-8400-5770"},"institutions":[{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]},{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Santiago Frid","raw_affiliation_strings":["Hospital Clinic of Barcelona, 08036, Barcelona, Spain","University of Barcelona, 08007, Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Clinic of Barcelona, 08036, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"University of Barcelona, 08007, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091224685","display_name":"Dyana Sanchez","orcid":"https://orcid.org/0009-0004-1309-1199"},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"David S\u00e1nchez","raw_affiliation_strings":["Hospital Clinic of Barcelona, 08036, Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Clinic of Barcelona, 08036, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072909652","display_name":"X. Borrat","orcid":"https://orcid.org/0000-0002-9348-9284"},"institutions":[{"id":"https://openalex.org/I4210115097","display_name":"Hospital Cl\u00ednic de Barcelona","ror":"https://ror.org/02a2kzf50","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210115097"]},{"id":"https://openalex.org/I71999127","display_name":"Universitat de Barcelona","ror":"https://ror.org/021018s57","country_code":"ES","type":"education","lineage":["https://openalex.org/I71999127"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xavier Borrat","raw_affiliation_strings":["Hospital Clinic of Barcelona, 08036, Barcelona, Spain","University of Barcelona, 08007, Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"Hospital Clinic of Barcelona, 08036, Barcelona, Spain","institution_ids":["https://openalex.org/I4210115097"]},{"raw_affiliation_string":"University of Barcelona, 08007, Barcelona, Spain","institution_ids":["https://openalex.org/I71999127"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023037777"],"corresponding_institution_ids":["https://openalex.org/I71999127","https://openalex.org/I8765205"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.78325123,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"185","last_page":"195"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.7872999906539917,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.7872999906539917,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.09000000357627869,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12946","display_name":"Fractal and DNA sequence analysis","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ighv","display_name":"IGHV@","score":0.9531999826431274},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"Chronic lymphocytic leukemia","score":0.6887999773025513},{"id":"https://openalex.org/keywords/entropy","display_name":"Entropy (arrow of time)","score":0.4106999933719635},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.3774999976158142},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.37290000915527344},{"id":"https://openalex.org/keywords/digital-polymerase-chain-reaction","display_name":"Digital polymerase chain reaction","score":0.3666999936103821}],"concepts":[{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.9531999826431274},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.6887999773025513},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46059998869895935},{"id":"https://openalex.org/C106301342","wikidata":"https://www.wikidata.org/wiki/Q4117933","display_name":"Entropy (arrow of time)","level":2,"score":0.4106999933719635},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3785000145435333},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.3774999976158142},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.37290000915527344},{"id":"https://openalex.org/C48126324","wikidata":"https://www.wikidata.org/wiki/Q5276136","display_name":"Digital polymerase chain reaction","level":4,"score":0.3666999936103821},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.33660000562667847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.31850001215934753},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.29989999532699585},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.2827000021934509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2720000147819519},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.26980000734329224},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C98638677","wikidata":"https://www.wikidata.org/wiki/Q2067051","display_name":"Mutation rate","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25839999318122864},{"id":"https://openalex.org/C2779012473","wikidata":"https://www.wikidata.org/wiki/Q3235015","display_name":"RAD51","level":4,"score":0.2531000077724457}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-032-08452-1_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-032-08452-1_15","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1993063664","https://openalex.org/W1993616033","https://openalex.org/W1995875735","https://openalex.org/W2034828191","https://openalex.org/W2093464117","https://openalex.org/W2131126556","https://openalex.org/W2140773464","https://openalex.org/W2147448885","https://openalex.org/W2413812548","https://openalex.org/W2590664894","https://openalex.org/W2624598927","https://openalex.org/W2728505921","https://openalex.org/W2755066803","https://openalex.org/W2799783533","https://openalex.org/W2886087547","https://openalex.org/W2915047734","https://openalex.org/W2916823148","https://openalex.org/W3027443406","https://openalex.org/W3032915113","https://openalex.org/W3042774676","https://openalex.org/W3091472020","https://openalex.org/W3100688200","https://openalex.org/W3128903602","https://openalex.org/W3198407702","https://openalex.org/W4315705280","https://openalex.org/W4360602903","https://openalex.org/W4367023679","https://openalex.org/W4390176461","https://openalex.org/W4390828887","https://openalex.org/W4399205574","https://openalex.org/W4399231889","https://openalex.org/W4401161479"],"related_works":[],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2025-11-28T08:55:08.230858","created_date":"2025-11-15T00:00:00"}