{"id":"https://openalex.org/W4400907163","doi":"https://doi.org/10.1007/978-3-031-66955-2_3","title":"Stochastic Uncertainty Quantification Techniques Fail to\u00a0Account for\u00a0Inter-analyst Variability in\u00a0White Matter Hyperintensity Segmentation","display_name":"Stochastic Uncertainty Quantification Techniques Fail to\u00a0Account for\u00a0Inter-analyst Variability in\u00a0White Matter Hyperintensity Segmentation","publication_year":2024,"publication_date":"2024-01-01","ids":{"openalex":"https://openalex.org/W4400907163","doi":"https://doi.org/10.1007/978-3-031-66955-2_3"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-031-66955-2_3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-66955-2_3","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-3-031-66955-2_3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5093016048","display_name":"Ben Philps","orcid":"https://orcid.org/0009-0006-7999-2584"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Ben Philps","raw_affiliation_strings":["School of Informatics, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"School of Informatics, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025285051","display_name":"Mar\u00eda Vald\u00e9s Hern\u00e1ndez","orcid":"https://orcid.org/0000-0003-2771-6546"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Maria del C. Valdes Hernandez","raw_affiliation_strings":["Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003194031","display_name":"Susana Mu\u00f1oz Maniega","orcid":"https://orcid.org/0000-0001-5185-6384"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Susana Munoz Maniega","raw_affiliation_strings":["Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034776089","display_name":"Mark E. Bastin","orcid":"https://orcid.org/0000-0002-0490-0845"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark E. Bastin","raw_affiliation_strings":["Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054011304","display_name":"E. Sakka","orcid":"https://orcid.org/0000-0002-9116-3432"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Eleni Sakka","raw_affiliation_strings":["Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034315975","display_name":"\u00dana Clancy","orcid":"https://orcid.org/0000-0002-8062-7537"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Una Clancy","raw_affiliation_strings":["Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004889443","display_name":"Joanna M. Wardlaw","orcid":"https://orcid.org/0000-0002-9812-6642"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanna M. Wardlaw","raw_affiliation_strings":["Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Department of Neuroimaging Sciences, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015181633","display_name":"Miguel O. Bernab\u00e9u","orcid":"https://orcid.org/0000-0002-6456-3756"},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Miguel O. Bernabeu","raw_affiliation_strings":["Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK"],"affiliations":[{"raw_affiliation_string":"Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5093016048"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":{"value":5000,"currency":"EUR","value_usd":5392},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.25600807,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"34","last_page":"53"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10052","display_name":"Medical Image Segmentation Techniques","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.9715999960899353,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9635999798774719,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7650414705276489},{"id":"https://openalex.org/keywords/hyperintensity","display_name":"Hyperintensity","score":0.6631802320480347},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.521872878074646},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.42720186710357666},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.1307094693183899},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.06306448578834534},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.052824318408966064}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7650414705276489},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.6631802320480347},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.521872878074646},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.42720186710357666},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.1307094693183899},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.06306448578834534},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.052824318408966064}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-031-66955-2_3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-66955-2_3","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.1007/978-3-031-66955-2_3","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-66955-2_3","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2002514626","https://openalex.org/W2034510106","https://openalex.org/W2069424609","https://openalex.org/W2072290762","https://openalex.org/W2083252561","https://openalex.org/W2091931051","https://openalex.org/W2135989124","https://openalex.org/W2136573752","https://openalex.org/W2145661921","https://openalex.org/W2156717321","https://openalex.org/W2158742097","https://openalex.org/W2592929672","https://openalex.org/W2595489545","https://openalex.org/W2807861409","https://openalex.org/W2903804687","https://openalex.org/W2904422658","https://openalex.org/W2947592434","https://openalex.org/W2952735543","https://openalex.org/W2963076262","https://openalex.org/W2997179245","https://openalex.org/W3015910149","https://openalex.org/W3023221939","https://openalex.org/W3033549135","https://openalex.org/W3034976991","https://openalex.org/W3083847135","https://openalex.org/W3102100346","https://openalex.org/W3157886632","https://openalex.org/W3163963109","https://openalex.org/W3164731060","https://openalex.org/W3174508405","https://openalex.org/W4221129115","https://openalex.org/W4224926219","https://openalex.org/W4225373549","https://openalex.org/W4288424379","https://openalex.org/W4296122570","https://openalex.org/W4296193129","https://openalex.org/W4304195579","https://openalex.org/W4309635395","https://openalex.org/W4315781299","https://openalex.org/W4321018328","https://openalex.org/W4321760728","https://openalex.org/W4362663609","https://openalex.org/W4383377291","https://openalex.org/W4386065840","https://openalex.org/W4387225748","https://openalex.org/W4391164176","https://openalex.org/W6799272542","https://openalex.org/W6921538924"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2748952813","https://openalex.org/W2090103820","https://openalex.org/W2390279801","https://openalex.org/W3206072240","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2021468470","https://openalex.org/W2106430568","https://openalex.org/W2376932109"],"abstract_inverted_index":{"White":[0],"Matter":[1],"Hyperintensities":[2],"(WMH)":[3],"are":[4,190],"important":[5],"neuroradiological":[6],"markers":[7],"of":[8,35,73,172,184],"small":[9],"vessel":[10],"disease":[11],"in":[12,20,29,65,83,87,133,156,164],"brain":[13],"MRI,":[14],"with":[15,100],"automatic":[16],"segmentation":[17,34,102,167],"tasks":[18],"essential":[19],"research":[21],"and":[22,46,85,104,126,145,208],"clinical":[23],"settings":[24],"to":[25,40,180,204,211],"understand":[26],"their":[27,41],"role":[28],"individuals\u2019":[30],"health.":[31],"However":[32],"accurate":[33,61],"WMH":[36,62,88,128,166],"is":[37],"difficult":[38],"due":[39],"heterogeneous":[42],"shape,":[43],"intensity,":[44],"size":[45],"location.":[47],"Furthermore,":[48],"image":[49],"analysts":[50,188],"working":[51],"on":[52,96],"different":[53,57],"studies":[54,110],"have":[55],"adopted":[56],"approaches":[58,84,192],"for":[59,79],"providing":[60],"segmentations,":[63],"resulting":[64],"high":[66],"inter-analyst":[67],"variability.":[68],"We":[69,90,200],"assess":[70],"the":[71,81,113,121,127,162,165,170,182,206],"effectiveness":[72],"stochastic":[74,176],"uncertainty":[75,163],"quantification":[76],"(UQ)":[77],"techniques":[78,95],"bridging":[80],"variability":[82],"criteria":[86],"segmentation.":[89],"first":[91],"train":[92],"six":[93],"such":[94],"an":[97],"in-house":[98],"dataset":[99],"two":[101,138],"approaches,":[103],"then":[105],"evaluate":[106],"performance":[107],"across":[108],"three":[109],"unseen":[111],"by":[112,175,187],"model":[114],"when":[115],"training:":[116],"Mild":[117],"Stroke":[118],"Study":[119],"3,":[120],"Lothian":[122],"Birth":[123],"Cohort":[124],"1936":[125],"Challenge":[129],"dataset.":[130],"To":[131],"aid":[132],"our":[134],"analysis,":[135],"we":[136],"introduce":[137],"metrics:":[139],"Uncertainty":[140,147],"Inter":[141],"Rater":[142],"Overlap":[143,149],"(UIRO)":[144],"Joint":[146],"Error":[148],"(JUEO).":[150],"Our":[151],"results":[152],"show":[153],"that":[154,193],"changes":[155],"analyst":[157],"policy":[158],"between":[159],"datasets":[160],"dominates":[161],"task.":[168],"Crucially,":[169],"distribution":[171,183],"segmentations":[173,185],"predicted":[174],"models":[177],"can":[178],"fail":[179],"match":[181],"provided":[186],"who":[189],"following":[191],"differ":[194],"from":[195],"those":[196],"used":[197],"during":[198],"training.":[199],"further":[201],"suggest":[202],"how":[203],"modify":[205],"task":[207],"cost":[209],"function":[210],"overcome":[212],"these":[213],"difficulties.":[214]},"counts_by_year":[],"updated_date":"2025-12-26T23:08:49.675405","created_date":"2025-10-10T00:00:00"}