{"id":"https://openalex.org/W4388468293","doi":"https://doi.org/10.1007/978-3-031-47994-6_35","title":"Interpretable Weighted Siamese Network to\u00a0Predict the\u00a0Time to\u00a0Onset of\u00a0Alzheimer\u2019s Disease from\u00a0MRI Images","display_name":"Interpretable Weighted Siamese Network to\u00a0Predict the\u00a0Time to\u00a0Onset of\u00a0Alzheimer\u2019s Disease from\u00a0MRI Images","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4388468293","doi":"https://doi.org/10.1007/978-3-031-47994-6_35"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-031-47994-6_35","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-47994-6_35","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/978-3-031-47994-6_35","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058624041","display_name":"Misgina Tsighe Hagos","orcid":"https://orcid.org/0000-0002-9318-9417"},"institutions":[{"id":"https://openalex.org/I168346926","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I168346926"]}],"countries":["IE"],"is_corresponding":true,"raw_author_name":"Misgina Tsighe Hagos","raw_affiliation_strings":["School of Computer Science, Dublin, Ireland","Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-9318-9417","affiliations":[{"raw_affiliation_string":"School of Computer Science, Dublin, Ireland","institution_ids":[]},{"raw_affiliation_string":"Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland","institution_ids":["https://openalex.org/I168346926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085932960","display_name":"Niamh Belton","orcid":"https://orcid.org/0000-0003-4949-4745"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I168346926","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I168346926"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Niamh Belton","raw_affiliation_strings":["School of Medicine, University College Dublin, Dublin, Ireland","Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-4949-4745","affiliations":[{"raw_affiliation_string":"School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland","institution_ids":["https://openalex.org/I168346926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047043586","display_name":"Ronan P. Killeen","orcid":"https://orcid.org/0000-0002-9231-8133"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I4210102375","display_name":"Molecular Medicine Ireland","ror":"https://ror.org/00qvg6x21","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I4210102375"]},{"id":"https://openalex.org/I4210115218","display_name":"St. Vincent's University Hospital","ror":"https://ror.org/029tkqm80","country_code":"IE","type":"healthcare","lineage":["https://openalex.org/I4210115218"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ronan P. Killeen","raw_affiliation_strings":["Department of Radiology, Dublin, Ireland","School of Medicine, University College Dublin, Dublin, Ireland","UCD-SVUH PET CT Research Centre, St Vincent\u2019s University Hospital, Dublin, 4, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-9231-8133","affiliations":[{"raw_affiliation_string":"Department of Radiology, Dublin, Ireland","institution_ids":["https://openalex.org/I4210102375"]},{"raw_affiliation_string":"School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"UCD-SVUH PET CT Research Centre, St Vincent\u2019s University Hospital, Dublin, 4, Ireland","institution_ids":["https://openalex.org/I4210115218"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031311803","display_name":"Kathleen M. Curran","orcid":"https://orcid.org/0000-0003-0095-9337"},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I168346926","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I168346926"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Kathleen M. Curran","raw_affiliation_strings":["School of Medicine, University College Dublin, Dublin, Ireland","Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-0095-9337","affiliations":[{"raw_affiliation_string":"School of Medicine, University College Dublin, Dublin, Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland","institution_ids":["https://openalex.org/I168346926"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084251444","display_name":"Brian Mac Namee","orcid":"https://orcid.org/0000-0003-2518-0274"},"institutions":[{"id":"https://openalex.org/I168346926","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38","country_code":"IE","type":"nonprofit","lineage":["https://openalex.org/I168346926"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Brian Mac Namee","raw_affiliation_strings":["School of Computer Science, Dublin, Ireland","Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland"],"raw_orcid":"https://orcid.org/0000-0003-2518-0274","affiliations":[{"raw_affiliation_string":"School of Computer Science, Dublin, Ireland","institution_ids":[]},{"raw_affiliation_string":"Science Foundation Ireland Centre for Research Training in Machine Learning, Dublin, Ireland","institution_ids":["https://openalex.org/I168346926"]}]},{"author_position":"last","author":{"id":null,"display_name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058624041"],"corresponding_institution_ids":["https://openalex.org/I168346926"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":{"value":5000,"currency":"EUR","value_usd":5392},"fwci":2.0809,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.89222414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"391","last_page":"403"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10862","display_name":"AI in cancer detection","score":0.9919999837875366,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6465269327163696},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"Cognitive impairment","score":0.5154586434364319},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5018699169158936},{"id":"https://openalex.org/keywords/weighting","display_name":"Weighting","score":0.4971809685230255},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.4374784827232361},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.41871178150177},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4167692959308624},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2959453761577606},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.11130693554878235},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.07455083727836609}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6465269327163696},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.5154586434364319},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5018699169158936},{"id":"https://openalex.org/C183115368","wikidata":"https://www.wikidata.org/wiki/Q856577","display_name":"Weighting","level":2,"score":0.4971809685230255},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.4374784827232361},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41871178150177},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4167692959308624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2959453761577606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11130693554878235},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.07455083727836609},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-031-47994-6_35","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-47994-6_35","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.1007/978-3-031-47994-6_35","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-47994-6_35","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1976900720","https://openalex.org/W2010925911","https://openalex.org/W2018317802","https://openalex.org/W2024814727","https://openalex.org/W2093602450","https://openalex.org/W2113463442","https://openalex.org/W2127589108","https://openalex.org/W2142367912","https://openalex.org/W2157364932","https://openalex.org/W2165840723","https://openalex.org/W2470394683","https://openalex.org/W2499216257","https://openalex.org/W2586179392","https://openalex.org/W2738454660","https://openalex.org/W2769782531","https://openalex.org/W2783188875","https://openalex.org/W2783215915","https://openalex.org/W2789488272","https://openalex.org/W2791282053","https://openalex.org/W2899335103","https://openalex.org/W2900207554","https://openalex.org/W2905035821","https://openalex.org/W3014080415","https://openalex.org/W3091905774","https://openalex.org/W3102124851","https://openalex.org/W3129402560","https://openalex.org/W4286506501","https://openalex.org/W4327919044"],"related_works":["https://openalex.org/W2180954594","https://openalex.org/W2366107444","https://openalex.org/W2052835778","https://openalex.org/W2049003611","https://openalex.org/W2127804977","https://openalex.org/W2108418243","https://openalex.org/W164103134","https://openalex.org/W2787352659","https://openalex.org/W4388145910","https://openalex.org/W1970611213"],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"Disease":[1],"(AD)":[2],"is":[3,17,115],"a":[4,63,113,134,147,168,178,186,212],"progressive":[5,89,130],"disease":[6],"preceded":[7],"by":[8],"Mild":[9],"Cognitive":[10],"Impairment":[11],"(MCI).":[12],"Early":[13],"detection":[14,30],"of":[15,25,31,40,88,129,158,171,203,208],"AD":[16,32,61,98,119,159],"crucial":[18],"for":[19],"making":[20],"treatment":[21],"decisions.":[22],"However,":[23],"most":[24],"the":[26,81,86,97,117,139,154,204,209],"literature":[27],"on":[28,34,161],"computer-assisted":[29],"focuses":[33],"classifying":[35],"brain":[36,163],"images":[37],"into":[38,52],"one":[39],"three":[41],"major":[42],"categories:":[43],"healthy,":[44],"MCI,":[45],"and":[46,66,74,101,173],"AD;":[47],"or":[48],"categorizing":[49],"MCI":[50,59,73,90,131],"patients":[51,132],"(1)":[53],"progressive:":[54],"those":[55,69],"who":[56,70],"progress":[57,76],"from":[58],"to":[60,77,83,109,116,141,143,152,156,177,189],"at":[62],"future":[64],"time,":[65],"(2)":[67],"stable:":[68],"stay":[71],"as":[72,104],"never":[75],"AD.":[78,144],"This":[79],"misses":[80],"opportunity":[82],"accurately":[84],"identify":[85],"trajectory":[87],"patients.":[91],"In":[92],"this":[93,122],"paper,":[94],"we":[95,124,196],"revisit":[96],"identification":[99],"task":[100,108],"re-frame":[102],"it":[103],"an":[105,126,201],"ordinal":[106,127],"classification":[107],"predict":[110,153],"how":[111],"close":[112],"patient":[114],"severe":[118],"stage.":[120],"To":[121],"end,":[123],"construct":[125],"dataset":[128],"with":[133,200],"prediction":[135],"target":[136],"that":[137,184],"indicates":[138],"time":[140,155],"progression":[142],"We":[145,165],"train":[146],"Siamese":[148],"network":[149],"(SN)":[150],"model":[151,213],"onset":[157],"based":[160],"MRI":[162],"images.":[164],"also":[166],"propose":[167],"Weighted":[169],"variety":[170],"SN":[172,190],"compare":[174],"its":[175],"performance":[176,193],"baseline":[179],"model.":[180],"Our":[181],"evaluations":[182],"show":[183],"incorporating":[185],"weighting":[187],"factor":[188],"brings":[191],"considerable":[192],"gain.":[194],"Moreover,":[195],"complement":[197],"our":[198],"results":[199],"interpretation":[202],"learned":[205],"embedding":[206],"space":[207],"SNs":[210],"using":[211],"explainability":[214],"technique.":[215]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1}],"updated_date":"2026-01-22T23:29:09.771500","created_date":"2025-10-10T00:00:00"}
