{"id":"https://openalex.org/W4387430367","doi":"https://doi.org/10.1007/978-3-031-45275-8_20","title":"Gene Interactions in\u00a0Survival Data Analysis: A Data-Driven Approach Using Restricted Mean Survival Time and\u00a0Literature Mining","display_name":"Gene Interactions in\u00a0Survival Data Analysis: A Data-Driven Approach Using Restricted Mean Survival Time and\u00a0Literature Mining","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387430367","doi":"https://doi.org/10.1007/978-3-031-45275-8_20"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-031-45275-8_20","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-45275-8_20","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-45275-8_20.pdf","source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-45275-8_20.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041220000","display_name":"Jaka Koko\u0161ar","orcid":"https://orcid.org/0000-0001-7834-4573"},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":true,"raw_author_name":"Jaka Koko\u0161ar","raw_affiliation_strings":["Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia"],"raw_orcid":"https://orcid.org/0000-0001-7834-4573","affiliations":[{"raw_affiliation_string":"Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092085776","display_name":"Martin \u0160pendl","orcid":"https://orcid.org/0009-0008-0796-8985"},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Martin \u0160pendl","raw_affiliation_strings":["Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia"],"raw_orcid":"https://orcid.org/0009-0008-0796-8985","affiliations":[{"raw_affiliation_string":"Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073792028","display_name":"Bla\u017e Zupan","orcid":"https://orcid.org/0000-0002-5864-7056"},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Bla\u017e Zupan","raw_affiliation_strings":["Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia"],"raw_orcid":"https://orcid.org/0000-0002-5864-7056","affiliations":[{"raw_affiliation_string":"Faculty of Computer and Information Science, University of Ljubljana, Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041220000"],"corresponding_institution_ids":["https://openalex.org/I153976015"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":{"value":5000,"currency":"EUR","value_usd":5392},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16311445,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"293","last_page":"307"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11710","display_name":"Biomedical Text Mining and Ontologies","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6343227624893188},{"id":"https://openalex.org/keywords/gene-interaction","display_name":"Gene interaction","score":0.5536127686500549},{"id":"https://openalex.org/keywords/biological-data","display_name":"Biological data","score":0.5182633399963379},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.45951998233795166},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.43408337235450745},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4172016978263855},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.39585012197494507},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31723663210868835},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.30907541513442993},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.14350730180740356},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.12375423312187195}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6343227624893188},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.5536127686500549},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.5182633399963379},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.45951998233795166},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.43408337235450745},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4172016978263855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.39585012197494507},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31723663210868835},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.30907541513442993},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14350730180740356},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12375423312187195}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-031-45275-8_20","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-45275-8_20","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-45275-8_20.pdf","source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":{"id":"doi:10.1007/978-3-031-45275-8_20","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-031-45275-8_20","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-031-45275-8_20.pdf","source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5769677123","display_name":"Artificial Intelligence and Intelligent Systems","funder_award_id":"P2-0209","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"},{"id":"https://openalex.org/G8779743826","display_name":"Defining a framework to ensure public trust in systems and applications of Artificial Intelligence","funder_award_id":"V2-2272","funder_id":"https://openalex.org/F4320322554","funder_display_name":"Javna Agencija za Raziskovalno Dejavnost RS"}],"funders":[{"id":"https://openalex.org/F4320322554","display_name":"Javna Agencija za Raziskovalno Dejavnost RS","ror":"https://ror.org/059bp8k51"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4387430367.pdf"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1169720518","https://openalex.org/W1867182292","https://openalex.org/W2000771269","https://openalex.org/W2005895632","https://openalex.org/W2009884071","https://openalex.org/W2011284201","https://openalex.org/W2016645182","https://openalex.org/W2072013249","https://openalex.org/W2129133658","https://openalex.org/W2130879249","https://openalex.org/W2154139219","https://openalex.org/W2468543693","https://openalex.org/W2580610149","https://openalex.org/W2612467560","https://openalex.org/W2791645463","https://openalex.org/W2801710305","https://openalex.org/W2900569176","https://openalex.org/W2989138019","https://openalex.org/W3004019904","https://openalex.org/W3008415901","https://openalex.org/W3021516242","https://openalex.org/W3038262846","https://openalex.org/W3089376649","https://openalex.org/W3093053585","https://openalex.org/W4200191473","https://openalex.org/W4214574808","https://openalex.org/W4226238994","https://openalex.org/W4377224939","https://openalex.org/W4379352228","https://openalex.org/W6913026662"],"related_works":["https://openalex.org/W2131550814","https://openalex.org/W2780318934","https://openalex.org/W1963483824","https://openalex.org/W3004256870","https://openalex.org/W2142915034","https://openalex.org/W2135329546","https://openalex.org/W2982110971","https://openalex.org/W1557813139","https://openalex.org/W2365477676","https://openalex.org/W2904117628"],"abstract_inverted_index":{"Abstract":[0],"Unveiling":[1],"gene":[2,19,46,69,87,148,173,188],"interactions":[3,47,114,129,149,189],"is":[4],"crucial":[5],"for":[6,18,68],"comprehending":[7],"biological":[8,143],"processes,":[9],"particularly":[10],"their":[11,27,75],"combined":[12],"impact":[13],"on":[14,97,170],"phenotypes.":[15],"Computational":[16],"methodologies":[17],"interaction":[20],"discovery":[21],"have":[22,155],"been":[23,156],"extensively":[24],"studied,":[25],"but":[26],"application":[28],"to":[29,34,44,140,164,186],"censored":[30],"data":[31,105],"has":[32],"yet":[33],"be":[35],"thoroughly":[36],"explored.":[37,158],"Our":[38,59,107],"work":[39],"introduces":[40],"a":[41,91,116,153,166,182],"data-driven":[42,184],"approach":[43,60,161,185],"identifying":[45],"that":[48,83],"profoundly":[49],"influence":[50],"survival":[51,57,65,191],"rates":[52],"through":[53],"the":[54,62,79,85,176],"use":[55],"of":[56,84,118],"analysis.":[58],"calculates":[61],"restricted":[63],"mean":[64],"time":[66],"(RMST)":[67],"pairs":[70,174],"and":[71,112,115,132,135,175],"compares":[72],"it":[73,89],"against":[74],"individual":[76,86],"expressions.":[77],"If":[78],"interaction\u2019s":[80],"RMST":[81],"exceeds":[82],"expressions,":[88],"suggests":[90],"potential":[92,147],"functional":[93],"association.":[94],"We":[95,121],"focused":[96],"L1000":[98],"landmark":[99],"genes":[100],"using":[101,136],"TCGA":[102],"na":[103],"METABRIC":[104],"sets.":[106],"findings":[108],"demonstrate":[109],"numerous":[110],"additive":[111],"competing":[113],"scarcity":[117],"XOR-type":[119],"interactions.":[120],"substantiated":[122],"our":[123,171],"results":[124],"by":[125],"cross-referencing":[126],"with":[127],"existing":[128],"in":[130],"STRING":[131],"BioGRID":[133],"databases":[134],"large":[137],"language":[138],"models":[139],"summarize":[141],"complex":[142],"data.":[144],"Although":[145],"many":[146],"were":[150],"hypothesized,":[151],"only":[152],"fraction":[154],"experimentally":[157],"This":[159],"novel":[160],"enables":[162],"biologists":[163],"initiate":[165],"further":[167],"investigation":[168],"based":[169],"ranked":[172],"generated":[177],"literature":[178],"summaries,":[179],"thus":[180],"offering":[181],"comprehensive,":[183],"understanding":[187],"affecting":[190],"rates.":[192]},"counts_by_year":[],"updated_date":"2026-07-29T14:22:42.915294","created_date":"2025-10-10T00:00:00"}
