{"id":"https://openalex.org/W4387210958","doi":"https://doi.org/10.1007/978-3-031-43993-3_45","title":"A Coupled-Mechanisms Modelling Framework for\u00a0Neurodegeneration","display_name":"A Coupled-Mechanisms Modelling Framework for\u00a0Neurodegeneration","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4387210958","doi":"https://doi.org/10.1007/978-3-031-43993-3_45"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-031-43993-3_45","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-031-43993-3_45","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101562781","display_name":"Tiantian He","orcid":"https://orcid.org/0000-0003-1670-438X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Tiantian He","raw_affiliation_strings":["UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001482992","display_name":"Elinor Thompson","orcid":"https://orcid.org/0000-0002-3954-9530"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elinor Thompson","raw_affiliation_strings":["UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068828321","display_name":"Anna Schroder","orcid":"https://orcid.org/0009-0001-0380-0674"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Schroder","raw_affiliation_strings":["UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075265609","display_name":"Neil P. Oxtoby","orcid":"https://orcid.org/0000-0003-0203-3909"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Neil P. Oxtoby","raw_affiliation_strings":["UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008430715","display_name":"Ahmed Abdulaal","orcid":"https://orcid.org/0000-0002-1607-2514"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ahmed Abdulaal","raw_affiliation_strings":["UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064378373","display_name":"Frederik Barkhof","orcid":"https://orcid.org/0000-0003-3543-3706"},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Frederik Barkhof","raw_affiliation_strings":["Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, The Netherlands","UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","UCL Queen Square Institute of Neurology, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]},{"raw_affiliation_string":"UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]},{"raw_affiliation_string":"UCL Queen Square Institute of Neurology, University College London, London, UK","institution_ids":["https://openalex.org/I45129253","https://openalex.org/I4210151618"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033449704","display_name":"Daniel C. Alexander","orcid":"https://orcid.org/0000-0003-2439-350X"},"institutions":[{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Daniel C. Alexander","raw_affiliation_strings":["UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK"],"affiliations":[{"raw_affiliation_string":"UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK","institution_ids":["https://openalex.org/I45129253"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5101562781"],"corresponding_institution_ids":["https://openalex.org/I45129253"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":3.5713,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.92954582,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":null,"issue":null,"first_page":"459","last_page":"469"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9829999804496765,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.7677320241928101},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7440329790115356},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.582856297492981},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"Neurodegeneration","score":0.5212586522102356},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.4799085557460785},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.4597473740577698},{"id":"https://openalex.org/keywords/trajectory","display_name":"Trajectory","score":0.4283480644226074},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.41800445318222046},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.41223666071891785},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3242719769477844},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.17009013891220093},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.16060605645179749},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.14304444193840027}],"concepts":[{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.7677320241928101},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7440329790115356},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.582856297492981},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.5212586522102356},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.4799085557460785},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.4597473740577698},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.4283480644226074},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41800445318222046},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.41223666071891785},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3242719769477844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17009013891220093},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16060605645179749},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14304444193840027},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-031-43993-3_45","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-031-43993-3_45","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2810537366","display_name":null,"funder_award_id":"EP/M020533/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"},{"id":"https://openalex.org/G7748914543","display_name":null,"funder_award_id":"MR/T046422/1","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W795339718","https://openalex.org/W1983482668","https://openalex.org/W2024729467","https://openalex.org/W2076220672","https://openalex.org/W2080816290","https://openalex.org/W2089691915","https://openalex.org/W2101135654","https://openalex.org/W2129823286","https://openalex.org/W2158592797","https://openalex.org/W2167822639","https://openalex.org/W2592672814","https://openalex.org/W2782660935","https://openalex.org/W2796022617","https://openalex.org/W2808651428","https://openalex.org/W2897613819","https://openalex.org/W2970898057","https://openalex.org/W2991808555","https://openalex.org/W3030476832","https://openalex.org/W3094551933","https://openalex.org/W3109839649","https://openalex.org/W3143007731","https://openalex.org/W3157186248","https://openalex.org/W3208196021","https://openalex.org/W4282016234","https://openalex.org/W4296031138"],"related_works":["https://openalex.org/W2764192351","https://openalex.org/W2794217300","https://openalex.org/W2366107444","https://openalex.org/W2965213848","https://openalex.org/W2102136350","https://openalex.org/W4388145910","https://openalex.org/W1976205134","https://openalex.org/W1886844647","https://openalex.org/W2381570729","https://openalex.org/W4248336175"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-04-04T08:04:53.788161","created_date":"2025-10-10T00:00:00"}