{"id":"https://openalex.org/W4312705729","doi":"https://doi.org/10.1007/978-3-031-21175-1_12","title":"Search for\u00a0Zinc Complexes with\u00a0High Affinity in\u00a0Pyrazinamidase from\u00a0Mycobacterium Tuberculosis Resistant to\u00a0Pyrazinamide","display_name":"Search for\u00a0Zinc Complexes with\u00a0High Affinity in\u00a0Pyrazinamidase from\u00a0Mycobacterium Tuberculosis Resistant to\u00a0Pyrazinamide","publication_year":2022,"publication_date":"2022-01-01","ids":{"openalex":"https://openalex.org/W4312705729","doi":"https://doi.org/10.1007/978-3-031-21175-1_12"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-031-21175-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-031-21175-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011878989","display_name":"Jesus Antonio Alvarado-Huayhuaz","orcid":"https://orcid.org/0000-0003-4912-3178"},"institutions":[{"id":"https://openalex.org/I126460647","display_name":"Universidade Federal do Rio Grande","ror":"https://ror.org/05hpfkn88","country_code":"BR","type":"education","lineage":["https://openalex.org/I126460647"]},{"id":"https://openalex.org/I62520931","display_name":"National University of Engineering","ror":"https://ror.org/006v63s16","country_code":"PE","type":"education","lineage":["https://openalex.org/I62520931"]}],"countries":["BR","PE"],"is_corresponding":false,"raw_author_name":"Jesus Antonio Alvarado-Huayhuaz","raw_affiliation_strings":["COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil","Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru"],"raw_orcid":"https://orcid.org/0000-0003-4912-3178","affiliations":[{"raw_affiliation_string":"COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil","institution_ids":["https://openalex.org/I126460647"]},{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru","institution_ids":["https://openalex.org/I62520931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073163529","display_name":"Daniel Alonso Talaverano-Rojas","orcid":"https://orcid.org/0000-0002-7963-0886"},"institutions":[{"id":"https://openalex.org/I62520931","display_name":"National University of Engineering","ror":"https://ror.org/006v63s16","country_code":"PE","type":"education","lineage":["https://openalex.org/I62520931"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Daniel Alonso Talaverano-Rojas","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru"],"raw_orcid":"https://orcid.org/0000-0002-7963-0886","affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru","institution_ids":["https://openalex.org/I62520931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083237878","display_name":"Rene\u00e9 Isabel Huam\u00e1n Quispe","orcid":"https://orcid.org/0000-0003-2116-7478"},"institutions":[{"id":"https://openalex.org/I62520931","display_name":"National University of Engineering","ror":"https://ror.org/006v63s16","country_code":"PE","type":"education","lineage":["https://openalex.org/I62520931"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Rene\u00e9 Isabel Huam\u00e1n Quispe","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru"],"raw_orcid":"https://orcid.org/0000-0003-2116-7478","affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru","institution_ids":["https://openalex.org/I62520931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007342271","display_name":"Maur\u00edcio Dorneles Caldeira Balboni","orcid":"https://orcid.org/0000-0001-7653-0962"},"institutions":[{"id":"https://openalex.org/I126460647","display_name":"Universidade Federal do Rio Grande","ror":"https://ror.org/05hpfkn88","country_code":"BR","type":"education","lineage":["https://openalex.org/I126460647"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maur\u00edcio Dorneles Caldeira Balboni","raw_affiliation_strings":["COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7653-0962","affiliations":[{"raw_affiliation_string":"COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil","institution_ids":["https://openalex.org/I126460647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084154725","display_name":"Oscar E. A. Arce","orcid":"https://orcid.org/0000-0003-2603-1940"},"institutions":[{"id":"https://openalex.org/I126460647","display_name":"Universidade Federal do Rio Grande","ror":"https://ror.org/05hpfkn88","country_code":"BR","type":"education","lineage":["https://openalex.org/I126460647"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Oscar Emilio Arr\u00faa Arce","raw_affiliation_strings":["COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil"],"raw_orcid":"https://orcid.org/0000-0003-2603-1940","affiliations":[{"raw_affiliation_string":"COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil","institution_ids":["https://openalex.org/I126460647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068664163","display_name":"Adriano Velasque Werhli","orcid":"https://orcid.org/0000-0001-7107-5024"},"institutions":[{"id":"https://openalex.org/I126460647","display_name":"Universidade Federal do Rio Grande","ror":"https://ror.org/05hpfkn88","country_code":"BR","type":"education","lineage":["https://openalex.org/I126460647"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Adriano Velasque Werhli","raw_affiliation_strings":["COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil"],"raw_orcid":"https://orcid.org/0000-0001-7107-5024","affiliations":[{"raw_affiliation_string":"COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil","institution_ids":["https://openalex.org/I126460647"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086333993","display_name":"Karina Machado","orcid":"https://orcid.org/0000-0002-8966-5708"},"institutions":[{"id":"https://openalex.org/I126460647","display_name":"Universidade Federal do Rio Grande","ror":"https://ror.org/05hpfkn88","country_code":"BR","type":"education","lineage":["https://openalex.org/I126460647"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Karina dos Santos Machado","raw_affiliation_strings":["COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil"],"raw_orcid":"https://orcid.org/0000-0002-8966-5708","affiliations":[{"raw_affiliation_string":"COMBI-Lab, Grupo de Biologia Computacional, Centro de Ci\u00eancias Computacionais, Universidade Federal do Rio Grande, Rio Grande, RS, Brazil","institution_ids":["https://openalex.org/I126460647"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070693259","display_name":"Ana Valderrama","orcid":"https://orcid.org/0000-0001-7741-3207"},"institutions":[{"id":"https://openalex.org/I62520931","display_name":"National University of Engineering","ror":"https://ror.org/006v63s16","country_code":"PE","type":"education","lineage":["https://openalex.org/I62520931"]}],"countries":["PE"],"is_corresponding":false,"raw_author_name":"Ana Cecilia Valderrama-Negr\u00f3n","raw_affiliation_strings":["Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru"],"raw_orcid":"https://orcid.org/0000-0001-7741-3207","affiliations":[{"raw_affiliation_string":"Laboratorio de Investigaci\u00f3n en Biopol\u00edmeros y Metalof\u00e1rmacos (LIBIPMET), Facultad de Ciencias de la Universidad Nacional de Ingenier\u00eda, Lima, Peru","institution_ids":["https://openalex.org/I62520931"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56288344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":null,"issue":null,"first_page":"109","last_page":"120"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9860000014305115,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pyrazinamide","display_name":"Pyrazinamide","score":0.7728544473648071},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.7081587314605713},{"id":"https://openalex.org/keywords/mutant","display_name":"Mutant","score":0.5516831874847412},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5099819898605347},{"id":"https://openalex.org/keywords/terbium","display_name":"Terbium","score":0.47066888213157654},{"id":"https://openalex.org/keywords/zinc","display_name":"Zinc","score":0.45902878046035767},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3444124460220337},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.33164483308792114},{"id":"https://openalex.org/keywords/tuberculosis","display_name":"Tuberculosis","score":0.2966257929801941},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.29171907901763916},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2694547176361084},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.12239992618560791},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.11403286457061768},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.11236855387687683}],"concepts":[{"id":"https://openalex.org/C2780459521","wikidata":"https://www.wikidata.org/wiki/Q417571","display_name":"Pyrazinamide","level":4,"score":0.7728544473648071},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.7081587314605713},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5516831874847412},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5099819898605347},{"id":"https://openalex.org/C549856995","wikidata":"https://www.wikidata.org/wiki/Q1838","display_name":"Terbium","level":3,"score":0.47066888213157654},{"id":"https://openalex.org/C535196362","wikidata":"https://www.wikidata.org/wiki/Q758","display_name":"Zinc","level":2,"score":0.45902878046035767},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3444124460220337},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.33164483308792114},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.2966257929801941},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29171907901763916},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2694547176361084},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12239992618560791},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.11403286457061768},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.11236855387687683},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-031-21175-1_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-031-21175-1_12","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6299999952316284}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1950993160","https://openalex.org/W1988971060","https://openalex.org/W1991741456","https://openalex.org/W2046352089","https://openalex.org/W2066204878","https://openalex.org/W2069822781","https://openalex.org/W2073021822","https://openalex.org/W2079930055","https://openalex.org/W2095894081","https://openalex.org/W2102377211","https://openalex.org/W2120102911","https://openalex.org/W2126917152","https://openalex.org/W2293744162","https://openalex.org/W2583779325","https://openalex.org/W2781049624","https://openalex.org/W2794875394","https://openalex.org/W2797675659","https://openalex.org/W2902812092","https://openalex.org/W2911997094","https://openalex.org/W2955986556","https://openalex.org/W2968944936","https://openalex.org/W2979328457","https://openalex.org/W2981730085","https://openalex.org/W2998840182","https://openalex.org/W3004759689","https://openalex.org/W3015435728","https://openalex.org/W3098543521","https://openalex.org/W3117616919","https://openalex.org/W3128424752","https://openalex.org/W3151080724","https://openalex.org/W4200023542","https://openalex.org/W4214670167","https://openalex.org/W7016072582"],"related_works":["https://openalex.org/W2033848979","https://openalex.org/W2363761387","https://openalex.org/W2150579925","https://openalex.org/W4290228181","https://openalex.org/W2464993059","https://openalex.org/W2147448488","https://openalex.org/W2791697302","https://openalex.org/W2493613850","https://openalex.org/W2896632005","https://openalex.org/W2183266068"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-06-11T09:08:48.828518","created_date":"2025-10-10T00:00:00"}