{"id":"https://openalex.org/W3185579844","doi":"https://doi.org/10.1007/978-3-030-82427-3_1","title":"A High-Resolution Model of the Human Entorhinal Cortex in the \u2018BigBrain\u2019 \u2013 Use Case for Machine Learning and 3D Analyses","display_name":"A High-Resolution Model of the Human Entorhinal Cortex in the \u2018BigBrain\u2019 \u2013 Use Case for Machine Learning and 3D Analyses","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3185579844","doi":"https://doi.org/10.1007/978-3-030-82427-3_1","mag":"3185579844"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-030-82427-3_1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-030-82427-3_1","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-030-82427-3_1.pdf","source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/978-3-030-82427-3_1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050787950","display_name":"Sabrina Behuet","orcid":"https://orcid.org/0000-0002-4975-786X"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sabrina Behuet","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073016053","display_name":"Sebastian Bludau","orcid":"https://orcid.org/0000-0001-6173-9050"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Bludau","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036279842","display_name":"Olga Kedo","orcid":"https://orcid.org/0000-0002-0425-2323"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olga Kedo","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016982898","display_name":"Christian Schiffer","orcid":"https://orcid.org/0000-0002-2544-843X"},"institutions":[{"id":"https://openalex.org/I2801833913","display_name":"Ernst Ruska Centre","ror":"https://ror.org/03hass884","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I2801833913"]},{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Schiffer","raw_affiliation_strings":["Helmholtz AI, Research Centre J\u00fclich, J\u00fclich, Germany","Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz AI, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I2801833913"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014859866","display_name":"Timo Dickscheid","orcid":"https://orcid.org/0000-0002-9051-3701"},"institutions":[{"id":"https://openalex.org/I2801833913","display_name":"Ernst Ruska Centre","ror":"https://ror.org/03hass884","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758","https://openalex.org/I2801833913"]},{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Timo Dickscheid","raw_affiliation_strings":["Helmholtz AI, Research Centre J\u00fclich, J\u00fclich, Germany","Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Helmholtz AI, Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I2801833913"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059329979","display_name":"Andrea Brandstetter","orcid":null},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andrea Brandstetter","raw_affiliation_strings":["Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102845550","display_name":"Philippe Massicotte","orcid":"https://orcid.org/0000-0002-7170-2670"},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Philippe Massicotte","raw_affiliation_strings":["National Research Council of Canada (NRC), Ottawa, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Council of Canada (NRC), Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012689271","display_name":"Mona Omidyeganeh","orcid":null},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]},{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Mona Omidyeganeh","raw_affiliation_strings":["Department of Neurology and Neurosurgery, Montr\u00e9al Neurological Institute (MNI), McGill University, Montr\u00e9al, Canada","National Research Council of Canada (NRC), Ottawa, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurosurgery, Montr\u00e9al Neurological Institute (MNI), McGill University, Montr\u00e9al, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]},{"raw_affiliation_string":"National Research Council of Canada (NRC), Ottawa, Canada","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011305571","display_name":"Alan C. Evans","orcid":"https://orcid.org/0000-0003-3841-6098"},"institutions":[{"id":"https://openalex.org/I1292859797","display_name":"Montreal Neurological Institute and Hospital","ror":"https://ror.org/05ghs6f64","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1292859797"]},{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alan Evans","raw_affiliation_strings":["Department of Neurology and Neurosurgery, Montr\u00e9al Neurological Institute (MNI), McGill University, Montr\u00e9al, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neurosurgery, Montr\u00e9al Neurological Institute (MNI), McGill University, Montr\u00e9al, Canada","institution_ids":["https://openalex.org/I1292859797","https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009333521","display_name":"Katrin Amunts","orcid":"https://orcid.org/0000-0001-5828-0867"},"institutions":[{"id":"https://openalex.org/I171892758","display_name":"Forschungszentrum J\u00fclich","ror":"https://ror.org/02nv7yv05","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I171892758"]},{"id":"https://openalex.org/I44260953","display_name":"Heinrich Heine University D\u00fcsseldorf","ror":"https://ror.org/024z2rq82","country_code":"DE","type":"education","lineage":["https://openalex.org/I44260953"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin Amunts","raw_affiliation_strings":["C. and O. Vogt Institute of Brain Research, Medical Faculty, Heinrich-Heine University, D\u00fcsseldorf, Germany","Forschungszentrum J\u00fclich, J\u00fclich, Germany","Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"C. and O. Vogt Institute of Brain Research, Medical Faculty, Heinrich-Heine University, D\u00fcsseldorf, Germany","institution_ids":["https://openalex.org/I44260953"]},{"raw_affiliation_string":"Forschungszentrum J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]},{"raw_affiliation_string":"Institute of Neuroscience and Medicine (INM-1), Research Centre J\u00fclich, J\u00fclich, Germany","institution_ids":["https://openalex.org/I171892758"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5050787950"],"corresponding_institution_ids":["https://openalex.org/I171892758"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":{"value":5000,"currency":"EUR","value_usd":5392},"fwci":4.545,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.94237695,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"3","last_page":"21"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9850999712944031,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/entorhinal-cortex","display_name":"Entorhinal cortex","score":0.6699858903884888},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6448884010314941},{"id":"https://openalex.org/keywords/data-set","display_name":"Data set","score":0.5495237708091736},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5121748447418213},{"id":"https://openalex.org/keywords/high-resolution","display_name":"High resolution","score":0.4972410500049591},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.46601158380508423},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4434092938899994},{"id":"https://openalex.org/keywords/visual-cortex","display_name":"Visual cortex","score":0.41920650005340576},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.27105024456977844},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.2635188698768616},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20727580785751343},{"id":"https://openalex.org/keywords/geology","display_name":"Geology","score":0.15300396084785461},{"id":"https://openalex.org/keywords/remote-sensing","display_name":"Remote sensing","score":0.08668962121009827}],"concepts":[{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.6699858903884888},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6448884010314941},{"id":"https://openalex.org/C58489278","wikidata":"https://www.wikidata.org/wiki/Q1172284","display_name":"Data set","level":2,"score":0.5495237708091736},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5121748447418213},{"id":"https://openalex.org/C3020199158","wikidata":"https://www.wikidata.org/wiki/Q210521","display_name":"High resolution","level":2,"score":0.4972410500049591},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.46601158380508423},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4434092938899994},{"id":"https://openalex.org/C2779345533","wikidata":"https://www.wikidata.org/wiki/Q75785","display_name":"Visual cortex","level":2,"score":0.41920650005340576},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27105024456977844},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.2635188698768616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20727580785751343},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.15300396084785461},{"id":"https://openalex.org/C62649853","wikidata":"https://www.wikidata.org/wiki/Q199687","display_name":"Remote sensing","level":1,"score":0.08668962121009827},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-3-030-82427-3_1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-030-82427-3_1","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-030-82427-3_1.pdf","source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},{"id":"pmh:oai:cisti-icist.nrc-cnrc.ca:cistinparc:789dbc80-1eb3-4ce9-94ad-dedd76a1ce9f","is_oa":true,"landing_page_url":"https://nrc-publications.canada.ca/eng/view/ft/?id=789dbc80-1eb3-4ce9-94ad-dedd76a1ce9f","pdf_url":null,"source":{"id":"https://openalex.org/S7407055245","display_name":"NPARC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"doi:10.1007/978-3-030-82427-3_1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/978-3-030-82427-3_1","pdf_url":"https://link.springer.com/content/pdf/10.1007/978-3-030-82427-3_1.pdf","source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.5699999928474426}],"awards":[{"id":"https://openalex.org/G4530127105","display_name":null,"funder_award_id":"945539","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G534784824","display_name":null,"funder_award_id":"Grant Agreement No. 945539","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G7842005466","display_name":null,"funder_award_id":"Horizon 2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8767435255","display_name":null,"funder_award_id":"945539","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3185579844.pdf","grobid_xml":"https://content.openalex.org/works/W3185579844.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1505548944","https://openalex.org/W1582697909","https://openalex.org/W1849621162","https://openalex.org/W1971847164","https://openalex.org/W1976405656","https://openalex.org/W1993940897","https://openalex.org/W2000214666","https://openalex.org/W2004347786","https://openalex.org/W2021199403","https://openalex.org/W2031291297","https://openalex.org/W2037192432","https://openalex.org/W2039706207","https://openalex.org/W2046836290","https://openalex.org/W2052742260","https://openalex.org/W2079942744","https://openalex.org/W2083461908","https://openalex.org/W2093898957","https://openalex.org/W2099540110","https://openalex.org/W2105788981","https://openalex.org/W2159838014","https://openalex.org/W2738397984","https://openalex.org/W2761787180","https://openalex.org/W2761829250","https://openalex.org/W2883183514","https://openalex.org/W2917941951","https://openalex.org/W2953741403","https://openalex.org/W2975634117","https://openalex.org/W4213069698"],"related_works":["https://openalex.org/W2385459031","https://openalex.org/W4241380783","https://openalex.org/W2044917364","https://openalex.org/W2027108423","https://openalex.org/W1855666948","https://openalex.org/W2758561209","https://openalex.org/W1548095260","https://openalex.org/W2781711915","https://openalex.org/W2112817590","https://openalex.org/W1555291398"],"abstract_inverted_index":{"Abstract":[0],"The":[1,121,219],"\u2018BigBrain\u2019":[2],"is":[3],"a":[4,18,67,127,223],"high-resolution":[5],"data":[6,30,230,235],"set":[7,31],"of":[8,37,58,88,106,115,118,164,167,175,187,196,204],"the":[9,41,56,110,184,205],"human":[10],"brain":[11],"that":[12,80],"enables":[13],"three-dimensional":[14],"(3D)":[15],"analyses":[16,87],"with":[17,137,177,198],"20":[19],"\u00b5m":[20],"spatial":[21],"resolution":[22],"at":[23],"nearly":[24],"cellular":[25],"level.":[26],"We":[27],"use":[28,224],"this":[29],"to":[32,132,161],"explore":[33],"pre-\u03b1":[34,107],"(cell)":[35],"islands":[36,81,108,136,166,215],"layer":[38,246],"2":[39,247],"in":[40,49,66,74,93,109,171,180,183,245],"entorhinal":[42],"cortex":[43],"(EC),":[44],"which":[45],"are":[46],"early":[47],"affected":[48],"Alzheimer\u2019s":[50],"disease":[51],"and":[52,69,91,104,126,134,150,194,202,213],"have":[53],"therefore":[54],"been":[55],"focus":[57],"research":[59],"for":[60,200,226,236],"many":[61],"years.":[62],"They":[63],"appear":[64],"mostly":[65],"round":[68,212],"elongated":[70,217],"shape":[71,90],"as":[72,147],"shown":[73],"microscopic":[75,229],"studies.":[76],"Some":[77],"studies":[78],"suggested":[79],"may":[82],"be":[83,162],"interconnected":[84,165],"based":[85,112],"on":[86,113],"their":[89,151],"size":[92,195],"two-dimensional":[94],"(2D)":[95],"space.":[96],"Here,":[97],"we":[98],"characterized":[99],"morphological":[100],"features":[101],"(shape,":[102],"size,":[103],"distribution)":[105],"\u2018BigBrain\u2019,":[111],"3D-reconstructions":[114],"gapless":[116],"series":[117],"cell-body-stained":[119],"sections.":[120],"EC":[122,188],"was":[123,130,153,157],"annotated":[124],"manually,":[125],"machine-learning":[128],"tool":[129],"trained":[131],"identify":[133],"segment":[135],"subsequent":[138],"visualization":[139],"using":[140],"high-performance":[141],"computing":[142],"(HPC).":[143],"Islands":[144],"were":[145,189,248],"visualized":[146],"3D":[148,207],"surfaces":[149],"geometry":[152],"analyzed.":[154],"Their":[155],"morphology":[156],"complex:":[158],"they":[159],"appeared":[160],"composed":[163],"different":[168],"types":[169],"found":[170,210],"2D":[172],"histological":[173],"sections":[174],"EC,":[176],"various":[178],"shapes":[179],"3D.":[181],"Differences":[182],"rostral-to-caudal":[185],"part":[186],"identified":[190],"by":[191],"specific":[192,243],"distribution":[193],"islands,":[197],"implications":[199],"connectivity":[201],"function":[203],"EC.":[206],"compactness":[208],"analysis":[209],"more":[211],"complex":[214],"than":[216],"ones.":[218],"present":[220],"study":[221],"represents":[222],"case":[225],"studying":[227],"large":[228],"sets.":[231],"It":[232],"provides":[233],"reference":[234],"studies,":[237],"e.g.":[238],"investigating":[239],"neurodegenerative":[240],"diseases,":[241],"where":[242],"alterations":[244],"previously":[249],"reported.":[250]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-05-09T13:55:54.758798","created_date":"2025-10-10T00:00:00"}
