{"id":"https://openalex.org/W2969276323","doi":"https://doi.org/10.1007/978-3-030-39881-1_6","title":"A Waste-Efficient Algorithm for Single-Droplet Sample Preparation on Microfluidic Chips","display_name":"A Waste-Efficient Algorithm for Single-Droplet Sample Preparation on Microfluidic Chips","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W2969276323","doi":"https://doi.org/10.1007/978-3-030-39881-1_6","mag":"2969276323"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-030-39881-1_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-39881-1_6","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"preprint","indexed_in":["arxiv","crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1908.09618","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104039425","display_name":"Miguel Gonzalez","orcid":null},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Miguel Coviello Gonzalez","raw_affiliation_strings":["University of California at Riverside, Riverside, California","University of California at Riverside, Riverside, California#TAB#"],"affiliations":[{"raw_affiliation_string":"University of California at Riverside, Riverside, California","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"University of California at Riverside, Riverside, California#TAB#","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024529572","display_name":"Marek Chrob\u00e1k","orcid":"https://orcid.org/0000-0002-8673-2709"},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marek Chrobak","raw_affiliation_strings":["University of California at Riverside, Riverside, California","University of California at Riverside, Riverside, California#TAB#"],"affiliations":[{"raw_affiliation_string":"University of California at Riverside, Riverside, California","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"University of California at Riverside, Riverside, California#TAB#","institution_ids":["https://openalex.org/I103635307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5104039425"],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":0.1037,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39345451,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"25","issue":null,"first_page":"1","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T12452","display_name":"Electrowetting and Microfluidic Technologies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2208","display_name":"Electrical and Electronic Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12784","display_name":"Modular Robots and Swarm Intelligence","score":0.9986000061035156,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11407","display_name":"Innovative Microfluidic and Catalytic Techniques Innovation","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microfluidics","display_name":"Microfluidics","score":0.7755827307701111},{"id":"https://openalex.org/keywords/mixing","display_name":"Mixing (physics)","score":0.6797986626625061},{"id":"https://openalex.org/keywords/dilution","display_name":"Dilution","score":0.6617121696472168},{"id":"https://openalex.org/keywords/sample","display_name":"Sample (material)","score":0.6121547818183899},{"id":"https://openalex.org/keywords/fluidics","display_name":"Fluidics","score":0.597438395023346},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.548341691493988},{"id":"https://openalex.org/keywords/sample-preparation","display_name":"Sample preparation","score":0.4913600981235504},{"id":"https://openalex.org/keywords/process","display_name":"Process (computing)","score":0.49135175347328186},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.472533255815506},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.4341438114643097},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.43287375569343567},{"id":"https://openalex.org/keywords/process-engineering","display_name":"Process engineering","score":0.4000805616378784},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3411734104156494},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.302840918302536},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3002021908760071},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.22029608488082886},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.20458030700683594},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.1943894624710083},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.18979710340499878},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.11721649765968323},{"id":"https://openalex.org/keywords/electrical-engineering","display_name":"Electrical engineering","score":0.0886915922164917},{"id":"https://openalex.org/keywords/thermodynamics","display_name":"Thermodynamics","score":0.08649119734764099}],"concepts":[{"id":"https://openalex.org/C8673954","wikidata":"https://www.wikidata.org/wiki/Q138845","display_name":"Microfluidics","level":2,"score":0.7755827307701111},{"id":"https://openalex.org/C138777275","wikidata":"https://www.wikidata.org/wiki/Q6884054","display_name":"Mixing (physics)","level":2,"score":0.6797986626625061},{"id":"https://openalex.org/C96618451","wikidata":"https://www.wikidata.org/wiki/Q3028008","display_name":"Dilution","level":2,"score":0.6617121696472168},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.6121547818183899},{"id":"https://openalex.org/C132651336","wikidata":"https://www.wikidata.org/wiki/Q185571","display_name":"Fluidics","level":2,"score":0.597438395023346},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.548341691493988},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.4913600981235504},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.49135175347328186},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.472533255815506},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.4341438114643097},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.43287375569343567},{"id":"https://openalex.org/C21880701","wikidata":"https://www.wikidata.org/wiki/Q2144042","display_name":"Process engineering","level":1,"score":0.4000805616378784},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3411734104156494},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.302840918302536},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3002021908760071},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.22029608488082886},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.20458030700683594},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.1943894624710083},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.18979710340499878},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.11721649765968323},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0886915922164917},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.08649119734764099},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1007/978-3-030-39881-1_6","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-030-39881-1_6","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},{"id":"doi:10.1145/3408297","is_oa":false,"landing_page_url":"https://doi.org/10.1145/3408297","pdf_url":null,"source":{"id":"https://openalex.org/S201104086","display_name":"ACM Journal of Experimental Algorithmics","issn_l":"1084-6654","issn":["1084-6654"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319798","host_organization_name":"Association for Computing Machinery","host_organization_lineage":["https://openalex.org/P4310319798"],"host_organization_lineage_names":["Association for Computing Machinery"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACM Journal of Experimental Algorithmics","raw_type":"journal-article"},{"id":"pmh:oai:arXiv.org:1908.09618","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1908.09618","pdf_url":"https://arxiv.org/pdf/1908.09618","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2969276323","is_oa":true,"landing_page_url":"https://arxiv.org/pdf/1908.09618.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"arXiv (Cornell University)","raw_type":null},{"id":"doi:10.48550/arxiv.1908.09618","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1908.09618","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1908.09618","is_oa":true,"landing_page_url":"http://arxiv.org/abs/1908.09618","pdf_url":"https://arxiv.org/pdf/1908.09618","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W97517313","https://openalex.org/W1980181699","https://openalex.org/W2036702954","https://openalex.org/W2052580805","https://openalex.org/W2084364074","https://openalex.org/W2109834102","https://openalex.org/W2168567259","https://openalex.org/W2172036636","https://openalex.org/W2810896378","https://openalex.org/W2936775186","https://openalex.org/W2945676131","https://openalex.org/W2949618841"],"related_works":["https://openalex.org/W3003233449","https://openalex.org/W2949618841","https://openalex.org/W2201606084","https://openalex.org/W2095086030","https://openalex.org/W2488722193","https://openalex.org/W2036702954","https://openalex.org/W2609159228","https://openalex.org/W2908675255","https://openalex.org/W2172036636","https://openalex.org/W2787751710","https://openalex.org/W2161283167","https://openalex.org/W2978104251","https://openalex.org/W2886451731","https://openalex.org/W3026382394","https://openalex.org/W1989752604","https://openalex.org/W2908737928","https://openalex.org/W3183585755","https://openalex.org/W175083226","https://openalex.org/W2974867200","https://openalex.org/W2570470915"],"abstract_inverted_index":{"We":[0,86],"address":[1],"the":[2,25,33,94,101,108],"problem":[3],"of":[4,24,27,47,104],"designing":[5,89],"microfluidic":[6],"chips":[7],"for":[8,83],"sample":[9,28,34,96],"preparation,":[10],"a":[11,71,105,128],"crucial":[12],"step":[13],"in":[14,18,60,140],"many":[15],"experimental":[16,141],"processes":[17],"chemical":[19],"and":[20,79,107,135],"biological":[21],"sciences.":[22],"One":[23],"objectives":[26],"preparation":[29],"is":[30,68,110,119],"to":[31,43,99,111],"dilute":[32],"fluid,":[35],"called":[36,41,63,123],"reactant,":[37],"using":[38],"another":[39],"fluid":[40,48,114],"buffer,":[42],"produce":[44],"desired":[45],"volumes":[46,62],"with":[49],"prespecified":[50],"reactant":[51],"concentrations.":[52],"In":[53],"our":[54],"model":[55],"these":[56],"fluids":[57],"are":[58],"manipulated":[59],"discrete":[61],"droplets.":[64],"The":[65],"dilution":[66],"process":[67],"represented":[69],"by":[70],"mixing":[72,91],"graph":[73],"whose":[74],"nodes":[75],"represent":[76,81],"1\u20131":[77],"micro-mixers":[78],"edges":[80],"channels":[82],"transporting":[84],"fluids.":[85],"focus":[87],"on":[88,133],"such":[90],"graphs":[92],"when":[93],"given":[95],"(also":[97],"referred":[98],"as":[100],"target)":[102],"consists":[103],"single-droplet,":[106],"objective":[109],"minimize":[112],"total":[113],"waste.":[115],"Our":[116],"main":[117],"contribution":[118],"an":[120],"efficient":[121],"algorithm":[122],"$$\\texttt":[124],"{RPRIS}$$":[125],"that":[126],"guarantees":[127],"better":[129],"provable":[130],"worst-case":[131],"bound":[132],"waste":[134],"significantly":[136],"outperforms":[137],"state-of-the-art":[138],"algorithms":[139],"comparison.":[142]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}