{"id":"https://openalex.org/W2293199826","doi":"https://doi.org/10.1007/978-1-60761-444-9_7","title":"Spectral Library Searching for Peptide Identification via Tandem MS","display_name":"Spectral Library Searching for Peptide Identification via Tandem MS","publication_year":2009,"publication_date":"2009-12-05","ids":{"openalex":"https://openalex.org/W2293199826","doi":"https://doi.org/10.1007/978-1-60761-444-9_7","mag":"2293199826","pmid":"https://pubmed.ncbi.nlm.nih.gov/20013366"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-444-9_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-444-9_7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010704175","display_name":"Henry Lam","orcid":"https://orcid.org/0000-0001-7928-0364"},"institutions":[{"id":"https://openalex.org/I200769079","display_name":"Hong Kong University of Science and Technology","ror":"https://ror.org/00q4vv597","country_code":"HK","type":"education","lineage":["https://openalex.org/I200769079"]}],"countries":["HK"],"is_corresponding":true,"raw_author_name":"Henry Lam","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Science and Technology, Clear Water Bay, Hong Kong, China. kehlam@ust.hk","Department of Chemical and Biomolecular Engineering, University of Science and Technology, Clear Water Bay, Hong Kong"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Science and Technology, Clear Water Bay, Hong Kong, China. kehlam@ust.hk","institution_ids":["https://openalex.org/I200769079"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Science and Technology, Clear Water Bay, Hong Kong","institution_ids":["https://openalex.org/I200769079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053361384","display_name":"Ruedi Aebersold","orcid":"https://orcid.org/0000-0002-9576-3267"},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]},{"id":"https://openalex.org/I3148997608","display_name":"Institute for Systems Biology","ror":"https://ror.org/02tpgw303","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I3148997608"]}],"countries":["CH","US"],"is_corresponding":false,"raw_author_name":"Ruedi Aebersold","raw_affiliation_strings":["Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland","The Institute for Systems Biology, Seattle, WA, USA"],"affiliations":[{"raw_affiliation_string":"Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I35440088"]},{"raw_affiliation_string":"The Institute for Systems Biology, Seattle, WA, USA","institution_ids":["https://openalex.org/I3148997608"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010704175"],"corresponding_institution_ids":["https://openalex.org/I200769079"],"apc_list":null,"apc_paid":null,"fwci":5.0034,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.95165004,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"604","issue":null,"first_page":"95","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12388","display_name":"Identification and Quantification in Food","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/workflow","display_name":"Workflow","score":0.6729758977890015},{"id":"https://openalex.org/keywords/tandem","display_name":"Tandem","score":0.6033326387405396},{"id":"https://openalex.org/keywords/tandem-mass-spectrometry","display_name":"Tandem mass spectrometry","score":0.5851958394050598},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5847772359848022},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5196951031684875},{"id":"https://openalex.org/keywords/sequence-database","display_name":"Sequence database","score":0.5034634470939636},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.48211097717285156},{"id":"https://openalex.org/keywords/database-search-engine","display_name":"Database search engine","score":0.4488091468811035},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.44517970085144043},{"id":"https://openalex.org/keywords/information-retrieval","display_name":"Information retrieval","score":0.428438663482666},{"id":"https://openalex.org/keywords/search-engine","display_name":"Search engine","score":0.2559904456138611},{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.2492971122264862},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.23603850603103638},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.1649700105190277},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1303533911705017},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10244482755661011},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.10059031844139099}],"concepts":[{"id":"https://openalex.org/C177212765","wikidata":"https://www.wikidata.org/wiki/Q627335","display_name":"Workflow","level":2,"score":0.6729758977890015},{"id":"https://openalex.org/C2777814067","wikidata":"https://www.wikidata.org/wiki/Q1752317","display_name":"Tandem","level":2,"score":0.6033326387405396},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.5851958394050598},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5847772359848022},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5196951031684875},{"id":"https://openalex.org/C41584329","wikidata":"https://www.wikidata.org/wiki/Q175902","display_name":"Sequence database","level":3,"score":0.5034634470939636},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.48211097717285156},{"id":"https://openalex.org/C48000682","wikidata":"https://www.wikidata.org/wiki/Q5227411","display_name":"Database search engine","level":3,"score":0.4488091468811035},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.44517970085144043},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.428438663482666},{"id":"https://openalex.org/C97854310","wikidata":"https://www.wikidata.org/wiki/Q19541","display_name":"Search engine","level":2,"score":0.2559904456138611},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.2492971122264862},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23603850603103638},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.1649700105190277},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1303533911705017},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10244482755661011},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.10059031844139099},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C146978453","wikidata":"https://www.wikidata.org/wiki/Q3798668","display_name":"Aerospace engineering","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1007/978-1-60761-444-9_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-444-9_7","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:20013366","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20013366","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":null},{"id":"pmh:oai:repository.hkust.edu.hk:1783.1-29930","is_oa":false,"landing_page_url":"http://repository.hkust.edu.hk/ir/Record/1783.1-29930","pdf_url":null,"source":{"id":"https://openalex.org/S4306401796","display_name":"Rare & Special e-Zone (The Hong Kong University of Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I200769079","host_organization_name":"Hong Kong University of Science and Technology","host_organization_lineage":["https://openalex.org/I200769079"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W1572033224","https://openalex.org/W2028421938","https://openalex.org/W2053827324","https://openalex.org/W2054395884","https://openalex.org/W2073637473","https://openalex.org/W2083870231","https://openalex.org/W2091375086","https://openalex.org/W2112078820","https://openalex.org/W2113765377","https://openalex.org/W2124907615","https://openalex.org/W2132899146","https://openalex.org/W2146103026"],"related_works":["https://openalex.org/W2099218842","https://openalex.org/W1982968560","https://openalex.org/W2551173651","https://openalex.org/W2208525230","https://openalex.org/W2002363204","https://openalex.org/W1509452406","https://openalex.org/W4308452317","https://openalex.org/W2116007721","https://openalex.org/W2004515150","https://openalex.org/W2913733222"],"abstract_inverted_index":{"Spectral":[0],"library":[1,40,74,111],"searching":[2,112],"is":[3,41],"a":[4,38,46,100],"new":[5],"approach":[6],"in":[7,71,89,113],"proteomic":[8],"data":[9,115],"analysis":[10,116],"that":[11],"promises":[12],"to":[13,67,94,107],"address":[14],"some":[15],"of":[16,19,49,83],"the":[17,24,69,72,76,81,104],"shortcomings":[18],"sequence":[20,95],"database":[21],"searching,":[22,37],"currently":[23],"dominant":[25],"method":[26],"for":[27,75,103],"inferring":[28],"peptide":[29,54],"identifications":[30],"from":[31,45],"tandem":[32],"mass":[33],"spectra.":[34,56],"In":[35],"spectral":[36,39,73,110],"first":[42],"meticulously":[43],"compiled":[44],"large":[47],"collection":[48],"previously":[50],"observed":[51],"and":[52,87,91],"identified":[53,63],"MS/MS":[55],"The":[57],"unknown":[58],"spectrum":[59],"can":[60],"then":[61],"be":[62],"by":[64],"comparing":[65],"it":[66],"all":[68],"candidates":[70],"best":[77],"match.":[78],"It":[79],"offers":[80],"benefits":[82],"tremendous":[84],"speed":[85],"gain":[86],"increase":[88],"sensitivity":[90],"selectivity,":[92],"compared":[93],"searching.":[96],"This":[97],"article":[98],"provides":[99],"concise":[101],"roadmap":[102],"proteomics":[105],"researchers":[106],"start":[108],"using":[109],"their":[114],"workflow.":[117]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}