{"id":"https://openalex.org/W2977489313","doi":"https://doi.org/10.1007/978-1-4939-9873-9_10","title":"Informed Use of Protein\u2013Protein Interaction Data: A Focus on the Integrated Interactions Database (IID)","display_name":"Informed Use of Protein\u2013Protein Interaction Data: A Focus on the Integrated Interactions Database (IID)","publication_year":2019,"publication_date":"2019-10-03","ids":{"openalex":"https://openalex.org/W2977489313","doi":"https://doi.org/10.1007/978-1-4939-9873-9_10","mag":"2977489313","pmid":"https://pubmed.ncbi.nlm.nih.gov/31583635"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4939-9873-9_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4939-9873-9_10","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085732287","display_name":"Chiara Pastrello","orcid":"https://orcid.org/0000-0002-1934-7472"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":null,"type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Chiara Pastrello","raw_affiliation_strings":["Krembil Research Institute, University Health Network, Toronto, ON, Canada","Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I4388446386"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038607647","display_name":"Max Kotlyar","orcid":"https://orcid.org/0000-0002-1111-8667"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":null,"type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Max Kotlyar","raw_affiliation_strings":["Krembil Research Institute, University Health Network, Toronto, ON, Canada","Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Krembil Research Institute, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I4388446386"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055656807","display_name":"Igor Juri\u0161ica","orcid":"https://orcid.org/0000-0002-2507-946X"},"institutions":[{"id":"https://openalex.org/I1325899441","display_name":"University Health Network","ror":"https://ror.org/042xt5161","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I207624831","display_name":"Slovak Academy of Sciences","ror":"https://ror.org/03h7qq074","country_code":"SK","type":"government","lineage":["https://openalex.org/I207624831"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]},{"id":"https://openalex.org/I4210145572","display_name":"Institute of Neuroimmunology of the Slovak Academy of Sciences","ror":"https://ror.org/05c516317","country_code":"SK","type":"facility","lineage":["https://openalex.org/I207624831","https://openalex.org/I4210145572"]},{"id":"https://openalex.org/I4388446386","display_name":"Krembil Research Institute","ror":"https://ror.org/01f6jys10","country_code":null,"type":"facility","lineage":["https://openalex.org/I1325899441","https://openalex.org/I1325899441","https://openalex.org/I2799337515","https://openalex.org/I4388446386"]}],"countries":["CA","SK"],"is_corresponding":true,"raw_author_name":"Igor Jurisica","raw_affiliation_strings":["Department of Computer Science, University of Toronto, Toronto, ON, Canada. juris@ai.utoronto.ca","Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. juris@ai.utoronto.ca","Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia. juris@ai.utoronto.ca","Krembil Research Institute, University Health Network, Toronto, ON, Canada. juris@ai.utoronto.ca","Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. juris@ai.utoronto.ca","Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Toronto, Toronto, ON, Canada. juris@ai.utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada. juris@ai.utoronto.ca","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia. juris@ai.utoronto.ca","institution_ids":["https://openalex.org/I4210145572","https://openalex.org/I207624831"]},{"raw_affiliation_string":"Krembil Research Institute, University Health Network, Toronto, ON, Canada. juris@ai.utoronto.ca","institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I4388446386"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada. juris@ai.utoronto.ca","institution_ids":["https://openalex.org/I2802654988"]},{"raw_affiliation_string":"Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2802654988","https://openalex.org/I1325899441"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5055656807"],"corresponding_institution_ids":["https://openalex.org/I1325899441","https://openalex.org/I185261750","https://openalex.org/I207624831","https://openalex.org/I2802654988","https://openalex.org/I4210145572","https://openalex.org/I4388446386"],"apc_list":null,"apc_paid":null,"fwci":3.8912,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.94984828,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"2074","issue":null,"first_page":"125","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.978600025177002,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.9281080961227417},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6874998807907104},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.6246790885925293},{"id":"https://openalex.org/keywords/protocol","display_name":"Protocol (science)","score":0.544222354888916},{"id":"https://openalex.org/keywords/variety","display_name":"Variety (cybernetics)","score":0.5273184180259705},{"id":"https://openalex.org/keywords/focus","display_name":"Focus (optics)","score":0.492288738489151},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.4303285479545593},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.35651689767837524},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32674312591552734},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.18789243698120117},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.058041006326675415}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.9281080961227417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6874998807907104},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.6246790885925293},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.544222354888916},{"id":"https://openalex.org/C136197465","wikidata":"https://www.wikidata.org/wiki/Q1729295","display_name":"Variety (cybernetics)","level":2,"score":0.5273184180259705},{"id":"https://openalex.org/C192209626","wikidata":"https://www.wikidata.org/wiki/Q190909","display_name":"Focus (optics)","level":2,"score":0.492288738489151},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.4303285479545593},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.35651689767837524},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32674312591552734},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.18789243698120117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.058041006326675415},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4939-9873-9_10","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4939-9873-9_10","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:31583635","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/31583635","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1985213868","https://openalex.org/W1995683190","https://openalex.org/W1999586982","https://openalex.org/W2006683252","https://openalex.org/W2012852001","https://openalex.org/W2043764521","https://openalex.org/W2052685738","https://openalex.org/W2062533676","https://openalex.org/W2069244164","https://openalex.org/W2077997913","https://openalex.org/W2089350319","https://openalex.org/W2095867585","https://openalex.org/W2098383595","https://openalex.org/W2100025044","https://openalex.org/W2100488300","https://openalex.org/W2101735923","https://openalex.org/W2103017472","https://openalex.org/W2110684048","https://openalex.org/W2118128448","https://openalex.org/W2118446779","https://openalex.org/W2122863289","https://openalex.org/W2125810455","https://openalex.org/W2127894639","https://openalex.org/W2130687290","https://openalex.org/W2135197754","https://openalex.org/W2136479434","https://openalex.org/W2149148688","https://openalex.org/W2152124140","https://openalex.org/W2167566248","https://openalex.org/W2168708357","https://openalex.org/W2409473205","https://openalex.org/W2534390616","https://openalex.org/W2537623931","https://openalex.org/W2588469192","https://openalex.org/W2793263870","https://openalex.org/W2793720977","https://openalex.org/W2899942534","https://openalex.org/W2915536738"],"related_works":["https://openalex.org/W2905433371","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4388422664","https://openalex.org/W4390569940","https://openalex.org/W4361193272","https://openalex.org/W2963326959","https://openalex.org/W4388685194","https://openalex.org/W4312407344","https://openalex.org/W2894289927"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3}],"updated_date":"2026-06-19T15:47:20.252518","created_date":"2025-10-10T00:00:00"}