{"id":"https://openalex.org/W3080479963","doi":"https://doi.org/10.1007/978-1-0716-0826-5_13","title":"Predicting Hot Spots Using a Deep Neural Network Approach","display_name":"Predicting Hot Spots Using a Deep Neural Network Approach","publication_year":2020,"publication_date":"2020-08-18","ids":{"openalex":"https://openalex.org/W3080479963","doi":"https://doi.org/10.1007/978-1-0716-0826-5_13","mag":"3080479963","pmid":"https://pubmed.ncbi.nlm.nih.gov/32804371"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-0716-0826-5_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-0716-0826-5_13","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044744702","display_name":"Ant\u00f3nio J. Preto","orcid":"https://orcid.org/0000-0003-4203-2230"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Ant\u00f3nio J. Preto","raw_affiliation_strings":["Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070410513","display_name":"Pedro Matos\u2010Filipe","orcid":"https://orcid.org/0000-0003-0492-0683"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Pedro Matos-Filipe","raw_affiliation_strings":["Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084170611","display_name":"Jos\u00e9 Guilherme de Almeida","orcid":"https://orcid.org/0000-0002-1887-0157"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 G. de Almeida","raw_affiliation_strings":["Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079723208","display_name":"Joana Mour\u00e3o","orcid":"https://orcid.org/0000-0002-1296-5964"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Mour\u00e3o","raw_affiliation_strings":["Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Institute for Interdisciplinary Research, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057247289","display_name":"Irina S. Moreira","orcid":"https://orcid.org/0000-0003-2970-5250"},"institutions":[{"id":"https://openalex.org/I76903346","display_name":"University of Coimbra","ror":"https://ror.org/04z8k9a98","country_code":"PT","type":"education","lineage":["https://openalex.org/I76903346"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Irina S. Moreira","raw_affiliation_strings":["Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. irina.moreira@cnc.uc.pt","Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. irina.moreira@cnc.uc.pt","University of Coimbra, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. irina.moreira@cnc.uc.pt","Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","University of Coimbra, Department of Life Sciences, University of Coimbra, Coimbra, Portugal","Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal"],"affiliations":[{"raw_affiliation_string":"Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal. irina.moreira@cnc.uc.pt","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal. irina.moreira@cnc.uc.pt","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"University of Coimbra, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. irina.moreira@cnc.uc.pt","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"University of Coimbra, Department of Life Sciences, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]},{"raw_affiliation_string":"Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I76903346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5044744702"],"corresponding_institution_ids":["https://openalex.org/I76903346"],"apc_list":null,"apc_paid":null,"fwci":1.8084,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.85417925,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2190","issue":null,"first_page":"267","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9940000176429749,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.7701435089111328},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7136703729629517},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5949519276618958},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.5747773051261902},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5124969482421875},{"id":"https://openalex.org/keywords/code","display_name":"Code (set theory)","score":0.49555909633636475},{"id":"https://openalex.org/keywords/replication","display_name":"Replication (statistics)","score":0.49052780866622925},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.4576176702976227},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4516139328479767},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.42239341139793396},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.41584742069244385},{"id":"https://openalex.org/keywords/deep-neural-networks","display_name":"Deep neural networks","score":0.4127502143383026},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.39061611890792847},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3878551721572876},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.11783230304718018},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09677112102508545}],"concepts":[{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.7701435089111328},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7136703729629517},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5949519276618958},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.5747773051261902},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5124969482421875},{"id":"https://openalex.org/C2776760102","wikidata":"https://www.wikidata.org/wiki/Q5139990","display_name":"Code (set theory)","level":3,"score":0.49555909633636475},{"id":"https://openalex.org/C12590798","wikidata":"https://www.wikidata.org/wiki/Q3933199","display_name":"Replication (statistics)","level":2,"score":0.49052780866622925},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.4576176702976227},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4516139328479767},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.42239341139793396},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.41584742069244385},{"id":"https://openalex.org/C2984842247","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep neural networks","level":3,"score":0.4127502143383026},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.39061611890792847},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3878551721572876},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.11783230304718018},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09677112102508545},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-0716-0826-5_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-0716-0826-5_13","pdf_url":null,"source":{"id":"https://openalex.org/S4210172139","display_name":"Methods in molecular biology","issn_l":"1064-3745","issn":["1064-3745","1940-6029"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in Molecular Biology","raw_type":"book-chapter"},{"id":"pmid:32804371","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32804371","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5299999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1505191356","https://openalex.org/W1537357919","https://openalex.org/W2002016471","https://openalex.org/W2039058965","https://openalex.org/W2045870710","https://openalex.org/W2101234009","https://openalex.org/W2103485392","https://openalex.org/W2114850508","https://openalex.org/W2136206140","https://openalex.org/W2146292423","https://openalex.org/W2156472837","https://openalex.org/W2342249984","https://openalex.org/W2462945209","https://openalex.org/W2475686134","https://openalex.org/W2561675875","https://openalex.org/W2742299251","https://openalex.org/W2786118190","https://openalex.org/W2808147451","https://openalex.org/W2890285536","https://openalex.org/W2899942534","https://openalex.org/W2901654183","https://openalex.org/W2919115771","https://openalex.org/W6829887170"],"related_works":["https://openalex.org/W4205713785","https://openalex.org/W3016766501","https://openalex.org/W4398287560","https://openalex.org/W4377865163","https://openalex.org/W3193857078","https://openalex.org/W2888956734","https://openalex.org/W3000197790","https://openalex.org/W4315865067","https://openalex.org/W2979433843","https://openalex.org/W3208304128"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2025-10-10T00:00:00"}
