{"id":"https://openalex.org/W1578921938","doi":"https://doi.org/10.1007/3-540-36481-1_8","title":"A Method for Estimating Metabolic Fluxes from Incomplete Isotopomer Information","display_name":"A Method for Estimating Metabolic Fluxes from Incomplete Isotopomer Information","publication_year":2003,"publication_date":"2003-01-01","ids":{"openalex":"https://openalex.org/W1578921938","doi":"https://doi.org/10.1007/3-540-36481-1_8","mag":"1578921938"},"language":"en","primary_location":{"id":"doi:10.1007/3-540-36481-1_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/3-540-36481-1_8","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091883185","display_name":"Juho Rousu","orcid":"https://orcid.org/0000-0002-0705-4314"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Juho Rousu","raw_affiliation_strings":["Department of Computer Science, University of Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112780412","display_name":"Ari Rantanen","orcid":null},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Ari Rantanen","raw_affiliation_strings":["Department of Computer Science, University of Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003676223","display_name":"Hannu Maaheimo","orcid":"https://orcid.org/0000-0001-6563-3421"},"institutions":[{"id":"https://openalex.org/I87653560","display_name":"VTT Technical Research Centre of Finland","ror":"https://ror.org/04b181w54","country_code":"FI","type":"nonprofit","lineage":["https://openalex.org/I4210089493","https://openalex.org/I87653560"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Hannu Maaheimo","raw_affiliation_strings":["VTT Biotechnology, Finland"],"affiliations":[{"raw_affiliation_string":"VTT Biotechnology, Finland","institution_ids":["https://openalex.org/I87653560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004439161","display_name":"Esa Pitk\u00e4nen","orcid":"https://orcid.org/0000-0002-9818-6370"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Esa Pitk\u00e4nen","raw_affiliation_strings":["Department of Computer Science, University of Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000157386","display_name":"Katja Saarela","orcid":null},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Katja Saarela","raw_affiliation_strings":["Department of Computer Science, University of Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058284151","display_name":"Esko Ukkonen","orcid":"https://orcid.org/0000-0002-5978-1505"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Esko Ukkonen","raw_affiliation_strings":["Department of Computer Science, University of Helsinki, Finland"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5091883185"],"corresponding_institution_ids":["https://openalex.org/I133731052"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":1.8925,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.86682404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"88","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotopomers","display_name":"Isotopomers","score":0.9618750214576721},{"id":"https://openalex.org/keywords/metabolic-flux-analysis","display_name":"Metabolic flux analysis","score":0.7664464712142944},{"id":"https://openalex.org/keywords/metabolic-network","display_name":"Metabolic network","score":0.7118344306945801},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7108929753303528},{"id":"https://openalex.org/keywords/flux","display_name":"Flux (metallurgy)","score":0.5668708086013794},{"id":"https://openalex.org/keywords/tracer","display_name":"TRACER","score":0.5237027406692505},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4696109890937805},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.4629304111003876},{"id":"https://openalex.org/keywords/metabolic-pathway","display_name":"Metabolic pathway","score":0.4573989510536194},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4469510614871979},{"id":"https://openalex.org/keywords/state","display_name":"State (computer science)","score":0.4151357114315033},{"id":"https://openalex.org/keywords/topology","display_name":"Topology (electrical circuits)","score":0.3523526191711426},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3469264507293701},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3070720434188843},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2601875066757202},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.2597067952156067},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1558222770690918},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13189908862113953},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.13090085983276367},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.10006022453308105}],"concepts":[{"id":"https://openalex.org/C127124265","wikidata":"https://www.wikidata.org/wiki/Q2100870","display_name":"Isotopomers","level":3,"score":0.9618750214576721},{"id":"https://openalex.org/C160941953","wikidata":"https://www.wikidata.org/wiki/Q6822342","display_name":"Metabolic flux analysis","level":3,"score":0.7664464712142944},{"id":"https://openalex.org/C101810790","wikidata":"https://www.wikidata.org/wiki/Q2263094","display_name":"Metabolic network","level":2,"score":0.7118344306945801},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7108929753303528},{"id":"https://openalex.org/C68709404","wikidata":"https://www.wikidata.org/wiki/Q1134475","display_name":"Flux (metallurgy)","level":2,"score":0.5668708086013794},{"id":"https://openalex.org/C2778863792","wikidata":"https://www.wikidata.org/wiki/Q16909918","display_name":"TRACER","level":2,"score":0.5237027406692505},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4696109890937805},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.4629304111003876},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4573989510536194},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4469510614871979},{"id":"https://openalex.org/C48103436","wikidata":"https://www.wikidata.org/wiki/Q599031","display_name":"State (computer science)","level":2,"score":0.4151357114315033},{"id":"https://openalex.org/C184720557","wikidata":"https://www.wikidata.org/wiki/Q7825049","display_name":"Topology (electrical circuits)","level":2,"score":0.3523526191711426},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3469264507293701},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3070720434188843},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2601875066757202},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2597067952156067},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1558222770690918},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13189908862113953},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.13090085983276367},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10006022453308105},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185544564","wikidata":"https://www.wikidata.org/wiki/Q81197","display_name":"Nuclear physics","level":1,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C32909587","wikidata":"https://www.wikidata.org/wiki/Q11369","display_name":"Molecule","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/3-540-36481-1_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/3-540-36481-1_8","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.58.8118","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.58.8118","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.cs.Helsinki.FI/u/rousu/papers/CMSB03.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1574470162","https://openalex.org/W1884145908","https://openalex.org/W1969684940","https://openalex.org/W1971645053","https://openalex.org/W2006696898","https://openalex.org/W2014348203","https://openalex.org/W2017721591","https://openalex.org/W2027476872","https://openalex.org/W2028655734","https://openalex.org/W2037430361","https://openalex.org/W2058701510","https://openalex.org/W2059902696","https://openalex.org/W2062870685","https://openalex.org/W2086475944","https://openalex.org/W2096767559","https://openalex.org/W2112794504","https://openalex.org/W2136811206","https://openalex.org/W2138688367","https://openalex.org/W2152745931","https://openalex.org/W2168491690","https://openalex.org/W6837811469"],"related_works":["https://openalex.org/W2095203814","https://openalex.org/W2238139779","https://openalex.org/W2996888210","https://openalex.org/W2086716992","https://openalex.org/W2006196154","https://openalex.org/W1578921938","https://openalex.org/W2341681417","https://openalex.org/W1574470162","https://openalex.org/W205613633","https://openalex.org/W3008616113"],"abstract_inverted_index":null,"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}