{"id":"https://openalex.org/W1563585769","doi":"https://doi.org/10.1007/11946465_13","title":"Dynamic Model of Amino Acid and Carbohydrate Metabolism in Primary Human Liver Cells","display_name":"Dynamic Model of Amino Acid and Carbohydrate Metabolism in Primary Human Liver Cells","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1563585769","doi":"https://doi.org/10.1007/11946465_13","mag":"1563585769"},"language":"en","primary_location":{"id":"doi:10.1007/11946465_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/11946465_13","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113767813","display_name":"Reinhard Guthke","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Reinhard Guthke","raw_affiliation_strings":["Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Knoell Institute, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Knoell Institute, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059750896","display_name":"Wolfgang Schmidt\u2010Heck","orcid":null},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang Schmidt-Heck","raw_affiliation_strings":["Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Knoell Institute, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"Leibniz Institute for Natural Product Research and Infection Biology \u2013 Hans Knoell Institute, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007240809","display_name":"Gesine Ple\u00df","orcid":null},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gesine Pless","raw_affiliation_strings":["Division of Experimental Surgery, Charit\u00e9 Campus Virchow, University Medicine Berlin, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Division of Experimental Surgery, Charit\u00e9 Campus Virchow, University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112090999","display_name":"Rolf Gebhardt","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rolf Gebhardt","raw_affiliation_strings":["Institute of Biochemistry, Medical Faculty, University Leipzig, Johannisallee 30, Leipzig, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, Medical Faculty, University Leipzig, Johannisallee 30, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065986624","display_name":"Michael Pfaff","orcid":"https://orcid.org/0000-0002-8523-7028"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Pfaff","raw_affiliation_strings":["BioControl Jena GmbH, Jena, Germany"],"affiliations":[{"raw_affiliation_string":"BioControl Jena GmbH, Jena, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108243454","display_name":"J Gerlach","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Joerg C. Gerlach","raw_affiliation_strings":["Depts of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA","Division of Experimental Surgery, Charit\u00e9 Campus Virchow, University Medicine Berlin, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Depts of Surgery and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, USA","institution_ids":["https://openalex.org/I4210155891","https://openalex.org/I170201317"]},{"raw_affiliation_string":"Division of Experimental Surgery, Charit\u00e9 Campus Virchow, University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078296617","display_name":"Katrin Zeilinger","orcid":"https://orcid.org/0000-0001-8448-2470"},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"funder","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katrin Zeilinger","raw_affiliation_strings":["Division of Experimental Surgery, Charit\u00e9 Campus Virchow, University Medicine Berlin, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Division of Experimental Surgery, Charit\u00e9 Campus Virchow, University Medicine Berlin, Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5113767813"],"corresponding_institution_ids":["https://openalex.org/I4210162077"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":9.7998,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.97673002,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"137","last_page":"149"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.7416517734527588},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.5988243222236633},{"id":"https://openalex.org/keywords/amino-acid","display_name":"Amino acid","score":0.5821637511253357},{"id":"https://openalex.org/keywords/urea","display_name":"Urea","score":0.5160250663757324},{"id":"https://openalex.org/keywords/urea-cycle","display_name":"Urea cycle","score":0.5103363394737244},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.5052209496498108},{"id":"https://openalex.org/keywords/sorbitol","display_name":"Sorbitol","score":0.45461711287498474},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3684740662574768},{"id":"https://openalex.org/keywords/arginine","display_name":"Arginine","score":0.07585757970809937}],"concepts":[{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.7416517734527588},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5988243222236633},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.5821637511253357},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.5160250663757324},{"id":"https://openalex.org/C77061444","wikidata":"https://www.wikidata.org/wiki/Q595994","display_name":"Urea cycle","level":4,"score":0.5103363394737244},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5052209496498108},{"id":"https://openalex.org/C2776779347","wikidata":"https://www.wikidata.org/wiki/Q245280","display_name":"Sorbitol","level":2,"score":0.45461711287498474},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3684740662574768},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.07585757970809937},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/11946465_13","is_oa":false,"landing_page_url":"https://doi.org/10.1007/11946465_13","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5799999833106995,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1483770168","https://openalex.org/W1486941581","https://openalex.org/W1995780597","https://openalex.org/W2031897773","https://openalex.org/W2041217729","https://openalex.org/W2048821978","https://openalex.org/W2076189082","https://openalex.org/W2505274713","https://openalex.org/W4242979567"],"related_works":["https://openalex.org/W2159072602","https://openalex.org/W2082736452","https://openalex.org/W2332614360","https://openalex.org/W2063769687","https://openalex.org/W2073023327","https://openalex.org/W2966146379","https://openalex.org/W2964617250","https://openalex.org/W2505847025","https://openalex.org/W2484055521","https://openalex.org/W2503167571"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}