{"id":"https://openalex.org/W1576838138","doi":"https://doi.org/10.1007/11779568_100","title":"Protein Stability Engineering in Staphylococcal Nuclease Using an AI-Neural Network Hybrid System and a Genetic Algorithm","display_name":"Protein Stability Engineering in Staphylococcal Nuclease Using an AI-Neural Network Hybrid System and a Genetic Algorithm","publication_year":2006,"publication_date":"2006-01-01","ids":{"openalex":"https://openalex.org/W1576838138","doi":"https://doi.org/10.1007/11779568_100","mag":"1576838138"},"language":"en","primary_location":{"id":"doi:10.1007/11779568_100","is_oa":false,"landing_page_url":"https://doi.org/10.1007/11779568_100","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069781603","display_name":"Christopher M. Frenz","orcid":null},"institutions":[{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher M. Frenz","raw_affiliation_strings":["Department of Biochemistry, New York Medical College, Valhalla","Dept of Biochemistry New York Medical College Valhalla NY"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, New York Medical College, Valhalla","institution_ids":["https://openalex.org/I181190671"]},{"raw_affiliation_string":"Dept of Biochemistry New York Medical College Valhalla NY","institution_ids":["https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069781603"],"corresponding_institution_ids":["https://openalex.org/I181190671"],"apc_list":{"value":5000,"currency":"EUR","value_usd":5392},"apc_paid":null,"fwci":1.1083,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.81679389,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"935","last_page":"942"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.98089998960495,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9789000153541565,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6806895732879639},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.6395052075386047},{"id":"https://openalex.org/keywords/stability","display_name":"Stability (learning theory)","score":0.6239073872566223},{"id":"https://openalex.org/keywords/nuclease","display_name":"Nuclease","score":0.4938843846321106},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.484280526638031},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.4831092357635498},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.4768301546573639},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.43201354146003723},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.41898220777511597},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3349483907222748},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.20155495405197144},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16847756505012512},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.14585599303245544},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12483888864517212}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6806895732879639},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.6395052075386047},{"id":"https://openalex.org/C112972136","wikidata":"https://www.wikidata.org/wiki/Q7595718","display_name":"Stability (learning theory)","level":2,"score":0.6239073872566223},{"id":"https://openalex.org/C2777271071","wikidata":"https://www.wikidata.org/wiki/Q422529","display_name":"Nuclease","level":3,"score":0.4938843846321106},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.484280526638031},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.4831092357635498},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.4768301546573639},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.43201354146003723},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41898220777511597},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3349483907222748},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.20155495405197144},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16847756505012512},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14585599303245544},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12483888864517212},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/11779568_100","is_oa":false,"landing_page_url":"https://doi.org/10.1007/11779568_100","pdf_url":null,"source":{"id":"https://openalex.org/S106296714","display_name":"Lecture notes in computer science","issn_l":"0302-9743","issn":["0302-9743","1611-3349"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lecture Notes in Computer Science","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W577989164","https://openalex.org/W1562919956","https://openalex.org/W1981888560","https://openalex.org/W1996320633","https://openalex.org/W2017519756","https://openalex.org/W2021271879","https://openalex.org/W2043814505","https://openalex.org/W2079306416","https://openalex.org/W2121519777","https://openalex.org/W2139897190","https://openalex.org/W2145644903","https://openalex.org/W2152279845"],"related_works":["https://openalex.org/W2030991979","https://openalex.org/W2030924841","https://openalex.org/W4386484109","https://openalex.org/W3190417955","https://openalex.org/W2064152244","https://openalex.org/W2031921252","https://openalex.org/W2472599461","https://openalex.org/W1992458278","https://openalex.org/W2039087468","https://openalex.org/W4248824361"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
