{"id":"https://openalex.org/W2079025483","doi":"https://doi.org/10.1002/ima.22089","title":"Structural brain changes in early\u2010onset and late\u2010onset depression: An update of volumetric MRI findings","display_name":"Structural brain changes in early\u2010onset and late\u2010onset depression: An update of volumetric MRI findings","publication_year":2014,"publication_date":"2014-05-05","ids":{"openalex":"https://openalex.org/W2079025483","doi":"https://doi.org/10.1002/ima.22089","mag":"2079025483"},"language":"en","primary_location":{"id":"doi:10.1002/ima.22089","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ima.22089","pdf_url":null,"source":{"id":"https://openalex.org/S15952048","display_name":"International Journal of Imaging Systems and Technology","issn_l":"0899-9457","issn":["0899-9457","1098-1098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Imaging Systems and Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078485468","display_name":"Mandy Tittmann","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mandy Tittmann","raw_affiliation_strings":["Department of Psychiatry University of Leipzig Leipzig Germany"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Leipzig Leipzig Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110329693","display_name":"Thomas G\u00fcnther","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas G\u00fcnther","raw_affiliation_strings":["Department of Psychiatry University of Leipzig Leipzig Germany"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Leipzig Leipzig Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065567566","display_name":"Julia Sacher","orcid":"https://orcid.org/0000-0003-0944-0558"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"id":"https://openalex.org/I4210119712","display_name":"Max Planck Institute for Mathematics","ror":"https://ror.org/02dh8ja68","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210119712"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julia Sacher","raw_affiliation_strings":["Clinic of Cognitive Neurology University Hospital Leipzig Leipzig Germany","Department of Neurology Max Planck Institute Leipzig Germany","Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Clinic of Cognitive Neurology University Hospital Leipzig Leipzig Germany","institution_ids":["https://openalex.org/I4210125843"]},{"raw_affiliation_string":"Department of Neurology Max Planck Institute Leipzig Germany","institution_ids":["https://openalex.org/I4210119712"]},{"raw_affiliation_string":"Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society","institution_ids":["https://openalex.org/I4210130445","https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008264973","display_name":"Hubertus Himmerich","orcid":"https://orcid.org/0000-0003-1209-6073"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hubertus Himmerich","raw_affiliation_strings":["Department of Psychiatry University of Leipzig Leipzig Germany"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Leipzig Leipzig Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020270555","display_name":"Arno Villringer","orcid":"https://orcid.org/0000-0003-2604-2404"},"institutions":[{"id":"https://openalex.org/I4210130445","display_name":"Max Planck Institute for Human Cognitive and Brain Sciences","ror":"https://ror.org/0387jng26","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210130445"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]},{"id":"https://openalex.org/I4210119712","display_name":"Max Planck Institute for Mathematics","ror":"https://ror.org/02dh8ja68","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210119712"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Arno Villringer","raw_affiliation_strings":["Clinic of Cognitive Neurology University Hospital Leipzig Leipzig Germany","Department of Neurology Max Planck Institute Leipzig Germany","Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society"],"affiliations":[{"raw_affiliation_string":"Clinic of Cognitive Neurology University Hospital Leipzig Leipzig Germany","institution_ids":["https://openalex.org/I4210125843"]},{"raw_affiliation_string":"Department of Neurology Max Planck Institute Leipzig Germany","institution_ids":["https://openalex.org/I4210119712"]},{"raw_affiliation_string":"Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society","institution_ids":["https://openalex.org/I4210130445","https://openalex.org/I149899117"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064639395","display_name":"Ulrich Hegerl","orcid":"https://orcid.org/0000-0002-3039-7470"},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich Hegerl","raw_affiliation_strings":["Department of Psychiatry University of Leipzig Leipzig Germany"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Leipzig Leipzig Germany","institution_ids":["https://openalex.org/I926574661"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055366347","display_name":"Peter Sch\u00f6nknecht","orcid":null},"institutions":[{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Peter Sch\u00f6nknecht","raw_affiliation_strings":["Department of Psychiatry University of Leipzig Leipzig Germany"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry University of Leipzig Leipzig Germany","institution_ids":["https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5055366347"],"corresponding_institution_ids":["https://openalex.org/I926574661"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.12234418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"2","first_page":"149","last_page":"160"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/orbitofrontal-cortex","display_name":"Orbitofrontal cortex","score":0.7772494554519653},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.7285591959953308},{"id":"https://openalex.org/keywords/hippocampus","display_name":"Hippocampus","score":0.7225306034088135},{"id":"https://openalex.org/keywords/depression","display_name":"Depression (economics)","score":0.6693530082702637},{"id":"https://openalex.org/keywords/neuropsychology","display_name":"Neuropsychology","score":0.6523194909095764},{"id":"https://openalex.org/keywords/amygdala","display_name":"Amygdala","score":0.6155790686607361},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.5855645537376404},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5402301549911499},{"id":"https://openalex.org/keywords/brain-size","display_name":"Brain size","score":0.5212001204490662},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3578149080276489},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.2920965552330017},{"id":"https://openalex.org/keywords/prefrontal-cortex","display_name":"Prefrontal cortex","score":0.22664973139762878},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.1362931728363037},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.10235631465911865}],"concepts":[{"id":"https://openalex.org/C2776559556","wikidata":"https://www.wikidata.org/wiki/Q18717","display_name":"Orbitofrontal cortex","level":4,"score":0.7772494554519653},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.7285591959953308},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7225306034088135},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6693530082702637},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.6523194909095764},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.6155790686607361},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5855645537376404},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5402301549911499},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.5212001204490662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3578149080276489},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2920965552330017},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.22664973139762878},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1362931728363037},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10235631465911865},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/ima.22089","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ima.22089","pdf_url":null,"source":{"id":"https://openalex.org/S15952048","display_name":"International Journal of Imaging Systems and Technology","issn_l":"0899-9457","issn":["0899-9457","1098-1098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Imaging Systems and Technology","raw_type":"journal-article"},{"id":"pmh:oai:escidoc.org:escidoc:2033974","is_oa":false,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0019-C17F-F","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W54111966","https://openalex.org/W132371621","https://openalex.org/W204854131","https://openalex.org/W1719169697","https://openalex.org/W1968214894","https://openalex.org/W1969392677","https://openalex.org/W1970221386","https://openalex.org/W1979951312","https://openalex.org/W1982277568","https://openalex.org/W1987528796","https://openalex.org/W1992144433","https://openalex.org/W1992416557","https://openalex.org/W1995671210","https://openalex.org/W2002050752","https://openalex.org/W2005501262","https://openalex.org/W2006201658","https://openalex.org/W2009580798","https://openalex.org/W2009782994","https://openalex.org/W2018887826","https://openalex.org/W2022094176","https://openalex.org/W2028173302","https://openalex.org/W2047189322","https://openalex.org/W2053859325","https://openalex.org/W2065267118","https://openalex.org/W2066238082","https://openalex.org/W2080768567","https://openalex.org/W2086826657","https://openalex.org/W2091326208","https://openalex.org/W2105688292","https://openalex.org/W2110763068","https://openalex.org/W2112423489","https://openalex.org/W2114077273","https://openalex.org/W2120499016","https://openalex.org/W2121298241","https://openalex.org/W2129253531","https://openalex.org/W2132156834","https://openalex.org/W2133258067","https://openalex.org/W2135628238","https://openalex.org/W2137114476","https://openalex.org/W2146088867","https://openalex.org/W2148146736","https://openalex.org/W2149977971","https://openalex.org/W2158130500","https://openalex.org/W2171092546","https://openalex.org/W2200648705","https://openalex.org/W2417869532","https://openalex.org/W2468443503","https://openalex.org/W2468996569","https://openalex.org/W2991792334","https://openalex.org/W3026624461","https://openalex.org/W3148499377","https://openalex.org/W4285719527","https://openalex.org/W6606413775"],"related_works":["https://openalex.org/W2413922126","https://openalex.org/W2065813708","https://openalex.org/W3028781422","https://openalex.org/W1987494247","https://openalex.org/W4229498114","https://openalex.org/W624134615","https://openalex.org/W2020461442","https://openalex.org/W1995446935","https://openalex.org/W1834612369","https://openalex.org/W1922104716"],"abstract_inverted_index":{"ABSTRACT":[0],"Early\u2010onset":[1],"(EOD)":[2],"and":[3,13,56,67],"late\u2010onset":[4],"depression":[5,39],"(LOD)":[6],"are":[7,30],"associated":[8,45],"with":[9,46],"different":[10],"neuropsychological":[11],"syndromes":[12],"structural":[14,23,62],"brain":[15,24,50],"changes.":[16],"In":[17],"this":[18],"article,":[19],"neuroimaging":[20],"studies":[21],"examining":[22],"changes":[25],"in":[26,40,49,53,84,87],"elderly":[27,42],"depressed":[28],"patients":[29],"reviewed.":[31],"The":[32],"presented":[33],"findings":[34],"support":[35],"current":[36],"assumptions":[37],"that":[38],"the":[41,54,57,69],"generally":[43],"is":[44],"volume":[47],"reductions":[48],"structures,":[51],"notably":[52],"hippocampus":[55],"orbitofrontal":[58],"cortex":[59],"(OFC).":[60],"Concerning":[61],"cerebral":[63],"differences":[64],"between":[65],"EOD":[66,88],"LOD,":[68],"review":[70],"yielded":[71],"conflicting":[72],"results\u2014only":[73],"for":[74,78],"OFC,":[75],"but":[76],"not":[77],"amygdala":[79],"or":[80],"hippocampus,":[81],"pronounced":[82],"effects":[83],"LOD":[85],"than":[86],"can":[89],"be":[90],"assumed.":[91],"\u00a9":[92],"2014":[93,104],"Wiley":[94],"Periodicals,":[95],"Inc.":[96],"Int":[97],"J":[98],"Imaging":[99],"Syst":[100],"Technol,":[101],"24,":[102],"149\u2013160,":[103]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
