{"id":"https://openalex.org/W4411529343","doi":"https://doi.org/10.1002/aisy.202500116","title":"Leveraging Compressed Sensing and Radiomics for Robust Feature Selection for Outcome Prediction in Personalized Ultra\u2010Fractionated Stereotactic Adaptive Radiotherapy","display_name":"Leveraging Compressed Sensing and Radiomics for Robust Feature Selection for Outcome Prediction in Personalized Ultra\u2010Fractionated Stereotactic Adaptive Radiotherapy","publication_year":2025,"publication_date":"2025-06-22","ids":{"openalex":"https://openalex.org/W4411529343","doi":"https://doi.org/10.1002/aisy.202500116"},"language":"en","primary_location":{"id":"doi:10.1002/aisy.202500116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aisy.202500116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202500116","source":{"id":"https://openalex.org/S4210212817","display_name":"Advanced Intelligent Systems","issn_l":"2640-4567","issn":["2640-4567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Intelligent Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202500116","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101764903","display_name":"Yajun Yu","orcid":"https://orcid.org/0000-0002-4073-7715"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yajun Yu","raw_affiliation_strings":["Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","Medical Artificial Intelligence and Automation Laboratory University of Texas Southwestern Medical Center  Dallas TX 75390 USA","Medical Artificial Intelligence and Automation Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA"],"raw_orcid":"https://orcid.org/0000-0002-4073-7715","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Medical Artificial Intelligence and Automation Laboratory University of Texas Southwestern Medical Center  Dallas TX 75390 USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Medical Artificial Intelligence and Automation Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018120191","display_name":"Steve Jiang","orcid":"https://orcid.org/0000-0002-3083-6752"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Jiang","raw_affiliation_strings":["Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","Medical Artificial Intelligence and Automation Laboratory University of Texas Southwestern Medical Center  Dallas TX 75390 USA","Medical Artificial Intelligence and Automation Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Medical Artificial Intelligence and Automation Laboratory University of Texas Southwestern Medical Center  Dallas TX 75390 USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Medical Artificial Intelligence and Automation Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068359755","display_name":"Robert Timmerman","orcid":"https://orcid.org/0000-0003-2462-1007"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Timmerman","raw_affiliation_strings":["Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101975125","display_name":"Hao Peng","orcid":"https://orcid.org/0000-0001-7018-8617"},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Hao Peng","raw_affiliation_strings":["Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","Medical Artificial Intelligence and Automation Laboratory University of Texas Southwestern Medical Center  Dallas TX 75390 USA","Medical Artificial Intelligence and Automation Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA"],"raw_orcid":"https://orcid.org/0000-0001-7018-8617","affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology University of Texas Southwestern Medical Center  Dallas TX 75390 USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Medical Artificial Intelligence and Automation Laboratory University of Texas Southwestern Medical Center  Dallas TX 75390 USA","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Medical Artificial Intelligence and Automation Laboratory, University of Texas Southwestern Medical Center, Dallas, TX, 75390 USA","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101975125"],"corresponding_institution_ids":["https://openalex.org/I867280407"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":3.6051,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.9284968,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"7","issue":"12","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/overfitting","display_name":"Overfitting","score":0.7437635064125061},{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.7235708236694336},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.6915010213851929},{"id":"https://openalex.org/keywords/lasso","display_name":"Lasso (programming language)","score":0.6774133443832397},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6547127962112427},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6372444033622742},{"id":"https://openalex.org/keywords/random-forest","display_name":"Random forest","score":0.5940306782722473},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.5211270451545715},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4971452057361603},{"id":"https://openalex.org/keywords/radiomics","display_name":"Radiomics","score":0.48758119344711304},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.4779236912727356},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.47328585386276245},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.43244022130966187},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3217729330062866},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.19686871767044067}],"concepts":[{"id":"https://openalex.org/C22019652","wikidata":"https://www.wikidata.org/wiki/Q331309","display_name":"Overfitting","level":3,"score":0.7437635064125061},{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.7235708236694336},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.6915010213851929},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.6774133443832397},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6547127962112427},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6372444033622742},{"id":"https://openalex.org/C169258074","wikidata":"https://www.wikidata.org/wiki/Q245748","display_name":"Random forest","level":2,"score":0.5940306782722473},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.5211270451545715},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4971452057361603},{"id":"https://openalex.org/C2778559731","wikidata":"https://www.wikidata.org/wiki/Q23808793","display_name":"Radiomics","level":2,"score":0.48758119344711304},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.4779236912727356},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.47328585386276245},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.43244022130966187},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3217729330062866},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.19686871767044067},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/aisy.202500116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aisy.202500116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202500116","source":{"id":"https://openalex.org/S4210212817","display_name":"Advanced Intelligent Systems","issn_l":"2640-4567","issn":["2640-4567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Intelligent Systems","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:91ad9beccbb34de7a1558f4dc2763b0e","is_oa":true,"landing_page_url":"https://doaj.org/article/91ad9beccbb34de7a1558f4dc2763b0e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Intelligent Systems, Vol 7, Iss 12, Pp n/a-n/a (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/aisy.202500116","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aisy.202500116","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202500116","source":{"id":"https://openalex.org/S4210212817","display_name":"Advanced Intelligent Systems","issn_l":"2640-4567","issn":["2640-4567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Intelligent Systems","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4411529343.pdf","grobid_xml":"https://content.openalex.org/works/W4411529343.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1611561580","https://openalex.org/W2051021899","https://openalex.org/W2057316742","https://openalex.org/W2068258779","https://openalex.org/W2097475056","https://openalex.org/W2104266187","https://openalex.org/W2120858702","https://openalex.org/W2122548617","https://openalex.org/W2128739912","https://openalex.org/W2135046866","https://openalex.org/W2140785063","https://openalex.org/W2174661749","https://openalex.org/W2499720122","https://openalex.org/W2586047144","https://openalex.org/W2763355946","https://openalex.org/W2767128594","https://openalex.org/W2900982152","https://openalex.org/W2947271486","https://openalex.org/W2978906693","https://openalex.org/W2984432074","https://openalex.org/W2998789541","https://openalex.org/W3006104185","https://openalex.org/W3103053050","https://openalex.org/W3118870642","https://openalex.org/W3121216533","https://openalex.org/W3134510327","https://openalex.org/W3135630532","https://openalex.org/W3139900359","https://openalex.org/W3148592396","https://openalex.org/W3172444956","https://openalex.org/W4200429026","https://openalex.org/W4206740500","https://openalex.org/W4226136430","https://openalex.org/W4250955649","https://openalex.org/W4294541781","https://openalex.org/W4296525169","https://openalex.org/W4310117627","https://openalex.org/W4320712996","https://openalex.org/W4375934093","https://openalex.org/W4376607984","https://openalex.org/W4386322185","https://openalex.org/W4387909104","https://openalex.org/W4389076530","https://openalex.org/W4389524993","https://openalex.org/W4390263004","https://openalex.org/W4391785436","https://openalex.org/W4394581521","https://openalex.org/W4395049331","https://openalex.org/W4400733447","https://openalex.org/W4403249003","https://openalex.org/W4403586616","https://openalex.org/W4407087893"],"related_works":["https://openalex.org/W4362597605","https://openalex.org/W1574414179","https://openalex.org/W2905433371","https://openalex.org/W4297676672","https://openalex.org/W3009056573","https://openalex.org/W2922073769","https://openalex.org/W4281702477","https://openalex.org/W2888392564","https://openalex.org/W4310278675","https://openalex.org/W4361806667"],"abstract_inverted_index":{"Personalized":[0],"ultra\u2010fractionated":[1],"stereotactic":[2],"adaptive":[3],"is":[4,27],"an":[5],"innovative":[6],"radiation":[7],"treatment":[8],"paradigm.":[9],"To":[10],"fully":[11],"harness":[12],"its":[13],"benefits,":[14],"transitioning":[15],"decision\u2010making":[16],"and":[17,52,62,140,157,182],"plan":[18],"adaptation":[19],"from":[20],"empirical":[21],"judgment":[22],"to":[23,68,85,180,193],"a":[24,32,69,94],"data\u2010driven":[25],"approach":[26],"essential.":[28],"This":[29],"study":[30],"presents":[31],"novel":[33],"compressed":[34],"sensing":[35],"(CS)\u2010based":[36],"feature":[37,57,155],"selection":[38,58,102,156,186],"method,":[39],"offering":[40],"distinct":[41],"advantages":[42],"over":[43,106],"conventional":[44],"approaches":[45],"such":[46],"as":[47],"the":[48,74,113,185,188],"Least":[49],"Absolute":[50],"Shrinkage":[51],"Selection":[53],"Operator":[54],"(Lasso).":[55],"Two":[56],"models":[59,82],"are":[60,83,178],"developed\u2014binary":[61],"Gaussian":[63],"random":[64],"projections\u2014and":[65],"applied":[66],"them":[67],"brain":[70],"metastasis":[71],"dataset.":[72],"Using":[73],"top":[75],"five":[76],"features":[77,192],"identified,":[78],"support":[79],"vector":[80],"machine":[81],"trained":[84],"classify":[86],"whether":[87],"lesions":[88],"achieved":[89],"\u226520%":[90],"volume":[91],"reduction":[92],"at":[93],"3\u2010month":[95],"follow\u2010up.":[96],"Integrating":[97],"residual":[98],"error":[99],"with":[100,171],"frequency\u2010based":[101],"further":[103],"enhances":[104],"performance":[105],"weight":[107],"coefficient\u2010based":[108],"criteria.":[109],"For":[110],"5\u2010feature":[111],"sets,":[112],"CS\u2010Binary":[114],"model":[115],"outperforms":[116],"Lasso":[117],"across":[118],"multiple":[119],"metrics:":[120],"AUC":[121],"(0.937":[122],"vs":[123,128,133,138,145],"0.890),":[124],"balanced":[125],"accuracy":[126],"(87.3%":[127],"83.0%),":[129],"F1":[130],"score":[131],"(79.4%":[132],"75.9%),":[134],"Kappa":[135],"coefficient":[136,143],"(75.8%":[137],"69.0%),":[139],"Matthews":[141],"correlation":[142],"(78.0%":[144],"72.1%).":[146],"The":[147],"CS\u2010based":[148],"framework":[149],"shows":[150],"great":[151],"potential":[152],"in":[153,163],"streamlining":[154],"improving":[158],"predictive":[159],"accuracy,":[160],"particularly":[161],"beneficial":[162],"two":[164],"scenarios:":[165],"1)":[166],"early":[167],"phase":[168],"clinical":[169],"trials":[170],"small":[172],"datasets":[173],"where":[174],"traditional":[175],"radiomics":[176],"methods":[177],"prone":[179],"overfitting;":[181],"2)":[183],"emphasizing":[184],"of":[187],"most":[189],"prognostically":[190],"relevant":[191],"help":[194],"improve":[195],"interpretability.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1}],"updated_date":"2026-05-06T08:25:59.206177","created_date":"2025-10-10T00:00:00"}