{"id":"https://openalex.org/W4396847629","doi":"https://doi.org/10.1002/aisy.202300773","title":"Improving Targeted Mass Spectrometry Data Analysis with Nested Active Machine Learning","display_name":"Improving Targeted Mass Spectrometry Data Analysis with Nested Active Machine Learning","publication_year":2024,"publication_date":"2024-05-12","ids":{"openalex":"https://openalex.org/W4396847629","doi":"https://doi.org/10.1002/aisy.202300773"},"language":"en","primary_location":{"id":"doi:10.1002/aisy.202300773","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aisy.202300773","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202300773","source":{"id":"https://openalex.org/S4210212817","display_name":"Advanced Intelligent Systems","issn_l":"2640-4567","issn":["2640-4567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Intelligent Systems","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202300773","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083819990","display_name":"Duran Bao","orcid":"https://orcid.org/0000-0001-9049-1947"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Duran Bao","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046100125","display_name":"Qingbo Shu","orcid":"https://orcid.org/0000-0002-6240-9712"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qingbo Shu","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680755","display_name":"Bo Ning","orcid":"https://orcid.org/0009-0002-3601-7544"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bo Ning","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111194314","display_name":"Michael Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Tang","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111294432","display_name":"Y.-Z. Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yubing Liu","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102663777","display_name":"Noel Wong","orcid":null},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Noel Wong","raw_affiliation_strings":["Department of Information Technology Tulane University  6823 St. Charles Avenue New Orleans LA 70118 USA","Department of Information Technology, Tulane University, 6823 St. Charles Avenue, New Orleans, LA, 70118 USA"],"affiliations":[{"raw_affiliation_string":"Department of Information Technology Tulane University  6823 St. Charles Avenue New Orleans LA 70118 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Information Technology, Tulane University, 6823 St. Charles Avenue, New Orleans, LA, 70118 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083458247","display_name":"Zhengming Ding","orcid":"https://orcid.org/0000-0002-6994-5278"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhengming Ding","raw_affiliation_strings":["Department of Computer Science School of Science and Engineering Tulane University  6823 St. Charles Avenue New Orleans LA 70118 USA","Department of Computer Science, School of Science and Engineering, Tulane University, 6823 St. Charles Avenue, New Orleans, LA, 70118 USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science School of Science and Engineering Tulane University  6823 St. Charles Avenue New Orleans LA 70118 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Computer Science, School of Science and Engineering, Tulane University, 6823 St. Charles Avenue, New Orleans, LA, 70118 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101615991","display_name":"Zizhan Zheng","orcid":"https://orcid.org/0000-0003-4799-1051"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zizhan Zheng","raw_affiliation_strings":["Department of Computer Science School of Science and Engineering Tulane University  6823 St. Charles Avenue New Orleans LA 70118 USA","Department of Computer Science, School of Science and Engineering, Tulane University, 6823 St. Charles Avenue, New Orleans, LA, 70118 USA"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science School of Science and Engineering Tulane University  6823 St. Charles Avenue New Orleans LA 70118 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Computer Science, School of Science and Engineering, Tulane University, 6823 St. Charles Avenue, New Orleans, LA, 70118 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035375125","display_name":"Christopher J. Lyon","orcid":"https://orcid.org/0000-0003-2319-2933"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher J. Lyon","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035245599","display_name":"Tony Hu","orcid":"https://orcid.org/0000-0002-5166-4937"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tony Hu","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025573000","display_name":"Jia Fan","orcid":"https://orcid.org/0000-0003-3384-0834"},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jia Fan","raw_affiliation_strings":["Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA"],"affiliations":[{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine Tulane University  1430 Tulane Avenue New Orleans LA 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology in School of Medicine, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Center for Cellular and Molecular Diagnostics, Tulane University, 1430 Tulane Avenue, New Orleans, LA, 70112 USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5025573000"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":2750,"currency":"USD","value_usd":2750},"apc_paid":{"value":2750,"currency":"USD","value_usd":2750},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.06908181,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"8","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.9818000197410583,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mass-spectrometry","display_name":"Mass spectrometry","score":0.600556492805481},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.49826812744140625},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3656575381755829},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.24668589234352112}],"concepts":[{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.600556492805481},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.49826812744140625},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3656575381755829},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.24668589234352112}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/aisy.202300773","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aisy.202300773","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202300773","source":{"id":"https://openalex.org/S4210212817","display_name":"Advanced Intelligent Systems","issn_l":"2640-4567","issn":["2640-4567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Intelligent Systems","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:2c4e4a714aaf438ebe976b68bef512ed","is_oa":true,"landing_page_url":"https://doaj.org/article/2c4e4a714aaf438ebe976b68bef512ed","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Advanced Intelligent Systems, Vol 6, Iss 8, Pp n/a-n/a (2024)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/aisy.202300773","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aisy.202300773","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aisy.202300773","source":{"id":"https://openalex.org/S4210212817","display_name":"Advanced Intelligent Systems","issn_l":"2640-4567","issn":["2640-4567"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Intelligent Systems","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4300000071525574}],"awards":[{"id":"https://openalex.org/G1470836995","display_name":null,"funder_award_id":"Start\u2010up","funder_id":"https://openalex.org/F4320310142","funder_display_name":"Tulane University"},{"id":"https://openalex.org/G817115943","display_name":null,"funder_award_id":"P20GM109036\u201007","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8449939621","display_name":null,"funder_award_id":"W8IXWH1910926","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320310142","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W4396847629.pdf"},"referenced_works_count":18,"referenced_works":["https://openalex.org/W2062143232","https://openalex.org/W2064208261","https://openalex.org/W2096451472","https://openalex.org/W2141091417","https://openalex.org/W2795726520","https://openalex.org/W2799338179","https://openalex.org/W2889976627","https://openalex.org/W2894933667","https://openalex.org/W2937307539","https://openalex.org/W2974836096","https://openalex.org/W2994716258","https://openalex.org/W2999615587","https://openalex.org/W3026521310","https://openalex.org/W3036047704","https://openalex.org/W3094483422","https://openalex.org/W3111278950","https://openalex.org/W4225728594","https://openalex.org/W4226051161"],"related_works":["https://openalex.org/W4387497383","https://openalex.org/W2948807893","https://openalex.org/W2778153218","https://openalex.org/W2748952813","https://openalex.org/W1531601525","https://openalex.org/W4391375266","https://openalex.org/W2078814861","https://openalex.org/W2527526854","https://openalex.org/W1976181487","https://openalex.org/W1986764834"],"abstract_inverted_index":{"Targeted":[0],"mass":[1],"spectrometry":[2],"(MS)":[3],"holds":[4],"promise":[5],"for":[6],"precise":[7],"protein":[8],"and":[9,13,28,60,68,77,100,112,125,129],"protein\u2010representative":[10],"peptide":[11],"identification":[12],"quantification,":[14],"enhancing":[15],"disease":[16],"diagnosis.":[17],"However,":[18],"its":[19],"clinical":[20,47,143],"application":[21,48],"is":[22,33],"hindered":[23],"by":[24,132],"complex":[25],"data":[26,42,99],"analysis":[27,43],"expert":[29],"review":[30],"requirements.":[31],"It":[32],"hypothesized":[34],"that":[35,57,101],"machine":[36],"learning":[37,136],"(ML)":[38],"models":[39,86,104,117],"can":[40,140],"automate":[41],"to":[44,75],"accelerate":[45],"the":[46],"of":[49],"MS.":[50],"The":[51,81],"approach":[52,139],"involves":[53],"an":[54,64],"ML\u2010driven":[55],"pipeline":[56],"extracts":[58],"statistical":[59],"morphological":[61],"features":[62,71,94],"from":[63],"MS":[65,144],"target":[66],"region":[67],"feeds":[69],"these":[70],"into":[72],"ML":[73,84],"algorithms":[74],"generate":[76],"assess":[78],"predictive":[79],"models.":[80],"findings":[82],"demonstrate":[83],"prediction":[85],"exhibit":[87,105],"superior":[88],"performance":[89,108],"when":[90],"trained":[91],"on":[92],"extracted":[93],"versus":[95],"raw":[96],"spectra":[97],"intensity":[98],"random":[102],"forest":[103],"robust":[106],"classification":[107],"in":[109],"both":[110],"internal":[111],"external":[113],"validation":[114],"datasets.":[115],"These":[116],"remain":[118],"effective":[119],"across":[120],"varying":[121],"training":[122],"dataset":[123],"sizes":[124],"positive":[126],"sample":[127],"rates":[128],"are":[130],"enhanced":[131],"a":[133],"nested":[134],"active":[135],"approach.":[137],"This":[138],"thus":[141],"revolutionize":[142],"applications.":[145]},"counts_by_year":[],"updated_date":"2026-03-27T14:29:43.386196","created_date":"2025-10-10T00:00:00"}
