{"id":"https://openalex.org/W2006360372","doi":"https://doi.org/10.1002/(sici)1098-1098(1997)8:3<240::aid-ima2>3.0.co;2-a","title":"Automated image analysis technologies for biological 3D light microscopy","display_name":"Automated image analysis technologies for biological 3D light microscopy","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W2006360372","doi":"https://doi.org/10.1002/(sici)1098-1098(1997)8:3<240::aid-ima2>3.0.co;2-a","mag":"2006360372"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-1098(1997)8:3<240::aid-ima2>3.0.co;2-a","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-1098(1997)8:3<240::aid-ima2>3.0.co;2-a","pdf_url":null,"source":{"id":"https://openalex.org/S15952048","display_name":"International Journal of Imaging Systems and Technology","issn_l":"0899-9457","issn":["0899-9457","1098-1098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Imaging Systems and Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056458521","display_name":"James N. Turner","orcid":"https://orcid.org/0000-0001-6034-1710"},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]},{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James N. Turner","raw_affiliation_strings":["Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590","Wadsworth Center, Box 509, Empire State Plaza, Albany, NY 12201\u20100509"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590","institution_ids":["https://openalex.org/I165799507"]},{"raw_affiliation_string":"Wadsworth Center, Box 509, Empire State Plaza, Albany, NY 12201\u20100509","institution_ids":["https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049422887","display_name":"Hakan Ancin","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hakan Ancin","raw_affiliation_strings":["Electrical, Computer & Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590"],"affiliations":[{"raw_affiliation_string":"Electrical, Computer & Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109464426","display_name":"Douglas E. Becker","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas E. Becker","raw_affiliation_strings":["Electrical, Computer & Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590"],"affiliations":[{"raw_affiliation_string":"Electrical, Computer & Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108510411","display_name":"Donald H. Szarowski","orcid":null},"institutions":[{"id":"https://openalex.org/I1339417872","display_name":"Wadsworth Center","ror":"https://ror.org/050kf9c55","country_code":"US","type":"facility","lineage":["https://openalex.org/I1298060332","https://openalex.org/I1339417872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. H. Szarowski","raw_affiliation_strings":["Wadsworth Center, Box 509, Empire State Plaza, Albany, NY 12201\u20100509"],"affiliations":[{"raw_affiliation_string":"Wadsworth Center, Box 509, Empire State Plaza, Albany, NY 12201\u20100509","institution_ids":["https://openalex.org/I1339417872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029352545","display_name":"Maria Holmes","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Holmes","raw_affiliation_strings":["AutoQuant Imaging, Inc., Troy, NY 12180"],"affiliations":[{"raw_affiliation_string":"AutoQuant Imaging, Inc., Troy, NY 12180","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058961578","display_name":"Nate O'Connor","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nate O'Connor","raw_affiliation_strings":["Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180\u20103590"],"affiliations":[{"raw_affiliation_string":"Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180\u20103590","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438316","display_name":"Michael Wang","orcid":"https://orcid.org/0000-0001-9748-5486"},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Wang","raw_affiliation_strings":["Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590"],"affiliations":[{"raw_affiliation_string":"Biomedical Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180-3590","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111722643","display_name":"Timothy Holmes","orcid":null},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy Holmes","raw_affiliation_strings":["Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180\u20103590"],"affiliations":[{"raw_affiliation_string":"Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180\u20103590","institution_ids":["https://openalex.org/I165799507"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090480130","display_name":"Badrinath Roysam","orcid":"https://orcid.org/0000-0002-8310-1389"},"institutions":[{"id":"https://openalex.org/I165799507","display_name":"Rensselaer Polytechnic Institute","ror":"https://ror.org/01rtyzb94","country_code":"US","type":"education","lineage":["https://openalex.org/I165799507"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Badrinath Roysam","raw_affiliation_strings":["Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180\u20103590"],"affiliations":[{"raw_affiliation_string":"Electrical, Computer, and Systems Engineering Department, Rensselaer Polytechnic Institute, Troy, NY 12180\u20103590","institution_ids":["https://openalex.org/I165799507"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5056458521"],"corresponding_institution_ids":["https://openalex.org/I1339417872","https://openalex.org/I165799507"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":null,"fwci":2.5445,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8919701,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"8","issue":"3","first_page":"240","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13114","display_name":"Image Processing Techniques and Applications","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2214","display_name":"Media Technology"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9866999983787537,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.8080483675003052},{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.7290205955505371},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6140173077583313},{"id":"https://openalex.org/keywords/tracing","display_name":"Tracing","score":0.5956827402114868},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.5744388103485107},{"id":"https://openalex.org/keywords/segmentation","display_name":"Segmentation","score":0.5243937373161316},{"id":"https://openalex.org/keywords/image-processing","display_name":"Image processing","score":0.5092772245407104},{"id":"https://openalex.org/keywords/blind-deconvolution","display_name":"Blind deconvolution","score":0.45781344175338745},{"id":"https://openalex.org/keywords/point-spread-function","display_name":"Point spread function","score":0.4374181628227234},{"id":"https://openalex.org/keywords/impulse-response","display_name":"Impulse response","score":0.4247279167175293},{"id":"https://openalex.org/keywords/image-segmentation","display_name":"Image segmentation","score":0.4240555763244629},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.3632592558860779},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.18991997838020325},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.10247683525085449}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.8080483675003052},{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.7290205955505371},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6140173077583313},{"id":"https://openalex.org/C138673069","wikidata":"https://www.wikidata.org/wiki/Q322229","display_name":"Tracing","level":2,"score":0.5956827402114868},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.5744388103485107},{"id":"https://openalex.org/C89600930","wikidata":"https://www.wikidata.org/wiki/Q1423946","display_name":"Segmentation","level":2,"score":0.5243937373161316},{"id":"https://openalex.org/C9417928","wikidata":"https://www.wikidata.org/wiki/Q1070689","display_name":"Image processing","level":3,"score":0.5092772245407104},{"id":"https://openalex.org/C30044814","wikidata":"https://www.wikidata.org/wiki/Q11334452","display_name":"Blind deconvolution","level":3,"score":0.45781344175338745},{"id":"https://openalex.org/C69179731","wikidata":"https://www.wikidata.org/wiki/Q510427","display_name":"Point spread function","level":2,"score":0.4374181628227234},{"id":"https://openalex.org/C72279823","wikidata":"https://www.wikidata.org/wiki/Q1139726","display_name":"Impulse response","level":2,"score":0.4247279167175293},{"id":"https://openalex.org/C124504099","wikidata":"https://www.wikidata.org/wiki/Q56933","display_name":"Image segmentation","level":3,"score":0.4240555763244629},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.3632592558860779},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.18991997838020325},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.10247683525085449},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1098-1098(1997)8:3<240::aid-ima2>3.0.co;2-a","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1098-1098(1997)8:3<240::aid-ima2>3.0.co;2-a","pdf_url":null,"source":{"id":"https://openalex.org/S15952048","display_name":"International Journal of Imaging Systems and Technology","issn_l":"0899-9457","issn":["0899-9457","1098-1098"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Imaging Systems and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.44999998807907104,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2058895457","https://openalex.org/W2586325539","https://openalex.org/W4327811029","https://openalex.org/W2023738877","https://openalex.org/W2001137152","https://openalex.org/W2115857766","https://openalex.org/W2790267366","https://openalex.org/W2011565119","https://openalex.org/W4327968231","https://openalex.org/W2075075842"],"abstract_inverted_index":{"Techniques":[0],"for":[1,48],"three-dimensional":[2],"(3D)":[3],"light":[4],"microscopy":[5],"of":[6,10,39,68,89,115,150],"a":[7,96],"wide":[8],"variety":[9],"biological":[11],"specimens":[12],"are":[13,19,157],"rapidly":[14],"maturing.":[15],"The":[16],"next":[17],"advances":[18],"to":[20,46,59,73,80,118,137],"improve":[21],"image":[22,25,41,90],"contrast,":[23],"make":[24],"resolution":[26],"as":[27,29,84,86],"isotropic":[28],"possible,":[30],"and":[31,43,75,79,128,134,154],"perform":[32],"quantitative":[33,60],"analysis.":[34],"This":[35],"article":[36],"discusses":[37],"methods":[38],"automatic":[40],"analysis":[42,61,91],"blind":[44],"deconvolution":[45,149],"compensate":[47],"the":[49,66,87,107,112,116],"microscope's":[50],"point-spread":[51],"function":[52],"(impulse":[53],"response).":[54],"Special":[55],"emphasis":[56],"is":[57],"given":[58],"based":[62],"on":[63,92],"adaptive":[64],"segmentation,":[65,141],"results":[67,88],"which":[69],"can":[70],"be":[71],"used":[72],"quantify":[74],"trace":[76],"individual":[77],"structures,":[78],"montage":[81],"high-resolution":[82],"fields":[83,94],"well":[85],"these":[93],"into":[95],"wide-area":[97],"view":[98],"with":[99,124],"an":[100],"associated":[101],"computer":[102],"database":[103],"representation.":[104],"We":[105],"exploit":[106],"specific":[108],"advantages":[109],"accruing":[110],"from":[111],"3D":[113,152],"nature":[114],"data":[117],"achieve":[119],"new":[120],"capabilities":[121],"not":[122],"possible":[123],"2D":[125],"imaging.":[126],"Fundamental":[127],"practical":[129],"challenges":[130],"in":[131],"this":[132],"area":[133],"our":[135],"progress":[136],"date":[138],"including":[139],"automated":[140],"cell":[142],"counting,":[143],"neuron":[144],"tracing,":[145],"mosaic":[146],"synthesis,":[147],"\"blind\"":[148],"large":[151],"images,":[153],"high-speed":[155],"computation":[156],"presented.":[158],"\u00a9":[159],"1997":[160,173],"John":[161],"Wiley":[162],"&":[163],"Sons,":[164],"Inc.":[165],"Int":[166],"J":[167],"Imaging":[168],"Syst":[169],"Technol,":[170],"8,":[171],"240\u2013254,":[172]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}