{"id":"https://openalex.org/W999858757","doi":null,"title":"Identification of Systemic Biomarkers in Serum, Urine, and Deoxyribonucleic Acid as Indictors for Environmental Exposures and the Development of Metabolic Outcomes Among Women in the United States","display_name":"Identification of Systemic Biomarkers in Serum, Urine, and Deoxyribonucleic Acid as Indictors for Environmental Exposures and the Development of Metabolic Outcomes Among Women in the United States","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W999858757","mag":"999858757"},"language":"en","primary_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt12n0v3f2","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/12n0v3f2","pdf_url":"https://escholarship.org/uc/item/12n0v3f2","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://escholarship.org/uc/item/12n0v3f2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101864751","display_name":"Yan Song","orcid":"https://orcid.org/0009-0006-1900-3203","observed_orcids":["https://orcid.org/0009-0006-1900-3203"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yan Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5101864751"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/endocrine-disruptors","display_name":"endocrine disruptors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/bisphenol-a","display_name":"bisphenol A","score":0.8379999995231628},{"id":"https://openalex.org/keywords/phthalate-metabolites","display_name":"phthalate metabolites","score":0.9570000171661377},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.609000027179718},{"id":"https://openalex.org/keywords/low-birth-weight","display_name":"low birth weight","score":0.7960000038146973},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8550000190734863},{"id":"https://openalex.org/keywords/sex-hormone-binding-globulin","display_name":"sex hormone-binding globulin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/e-selectin","display_name":"E-selectin","score":0.8989999890327454},{"id":"https://openalex.org/keywords/systolic-blood-pressure","display_name":"systolic blood pressure","score":0.8669999837875366},{"id":"https://openalex.org/keywords/persistent-organic-pollutants","display_name":"persistent organic pollutants","score":0.4399999976158142},{"id":"https://openalex.org/keywords/dioxins","display_name":"dioxins","score":0.6940000057220459},{"id":"https://openalex.org/keywords/polychlorinated-biphenyls","display_name":"polychlorinated biphenyls","score":0.9919999837875366},{"id":"https://openalex.org/keywords/organochlorine-pesticides","display_name":"organochlorine pesticides","score":0.9620000123977661},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.4449999928474426},{"id":"https://openalex.org/keywords/metabolic-outcomes","display_name":"metabolic outcomes","score":0.3319999873638153},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2781005124","wikidata":"https://www.wikidata.org/wiki/Q84483575","display_name":"Phthalate","level":2,"score":0.6069756150245667},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6043530702590942},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5379107594490051},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5238587856292725},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5177990198135376},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.5119732618331909},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.510090172290802},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4855306148529053},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.4530408978462219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44311416149139404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4151820242404938},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.38738542795181274},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3338354825973511},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2841477394104004},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1831265091896057},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:escholarship.org/ark:/13030/qt12n0v3f2","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/12n0v3f2","pdf_url":"https://escholarship.org/uc/item/12n0v3f2","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},{"id":"pmh:qt12n0v3f2","doi":null,"is_oa":false,"landing_page_url":"http://www.escholarship.org/uc/item/12n0v3f2","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Song, Yan. (2014). Identification of Systemic Biomarkers in Serum, Urine, and Deoxyribonucleic Acid as Indictors for Environmental Exposures and the Development of Metabolic Outcomes Among Women in the United States. UCLA: Epidemiology 0357. Retrieved from: http://www.escholarship.org/uc/item/12n0v3f2","raw_type":"dissertation"},{"id":"mag:999858757","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/content/qt12n0v3f2/qt12n0v3f2.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:escholarship.org/ark:/13030/qt12n0v3f2","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/12n0v3f2","pdf_url":"https://escholarship.org/uc/item/12n0v3f2","source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"etd"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9907000064849854}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2181697485","display_name":null,"funder_award_id":"R01DK62590","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2848036350","display_name":null,"funder_award_id":"/ NIDDK R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2979075132","display_name":"Biochemical and Genetic Markers of Type 2 Diabetes Risk","funder_award_id":"R01DK058845","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3711098856","display_name":"Boston Nutrition Obesity Research Center","funder_award_id":"P30DK046200","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4998814095","display_name":"Steroid Hormones, Adipose-cytokines, and Diabetes Risk","funder_award_id":"R01DK066401","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5543067959","display_name":"Harvard Transdisciplinary Research in Energetics and Cancer Center","funder_award_id":"U54CA155626","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G756856000","display_name":"Risk Factors for Breast Cancer in Younger Nurses","funder_award_id":"R01CA050385","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7927803508","display_name":"Dietary Polyphenols, Urinary Biomarkers & Risk of Type 2 Diabetes","funder_award_id":"R01DK082486","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8848928920","display_name":"Telomere and its bio-regulators as predictors for clinical diabetes in women","funder_award_id":"R21DK084452","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000171287","display_name":null,"funder_award_id":"DK 46200.","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000185549","display_name":null,"funder_award_id":"CA67262","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000192586","display_name":null,"funder_award_id":"DK58785","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000258924","display_name":null,"funder_award_id":"CA87969","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320324787","display_name":"Peking University","ror":"https://ror.org/02v51f717"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W999858757.pdf","grobid_xml":"https://content.openalex.org/works/W999858757.grobid-xml"},"referenced_works_count":75,"referenced_works":["https://openalex.org/W30632390","https://openalex.org/W1640894779","https://openalex.org/W1941832839","https://openalex.org/W1965097617","https://openalex.org/W1966222552","https://openalex.org/W1966915255","https://openalex.org/W1973034871","https://openalex.org/W1973376057","https://openalex.org/W1981132305","https://openalex.org/W1983673827","https://openalex.org/W1987658416","https://openalex.org/W1989909101","https://openalex.org/W1993104325","https://openalex.org/W1993994009","https://openalex.org/W2000054651","https://openalex.org/W2009478289","https://openalex.org/W2010336132","https://openalex.org/W2014305592","https://openalex.org/W2018910489","https://openalex.org/W2028647952","https://openalex.org/W2030445381","https://openalex.org/W2031792984","https://openalex.org/W2032528488","https://openalex.org/W2033585778","https://openalex.org/W2038970880","https://openalex.org/W2039225468","https://openalex.org/W2041454621","https://openalex.org/W2050892441","https://openalex.org/W2055218883","https://openalex.org/W2056250382","https://openalex.org/W2062168118","https://openalex.org/W2065707820","https://openalex.org/W2078899903","https://openalex.org/W2079217745","https://openalex.org/W2081132948","https://openalex.org/W2083812486","https://openalex.org/W2084963164","https://openalex.org/W2088471254","https://openalex.org/W2106883411","https://openalex.org/W2108900261","https://openalex.org/W2113421672","https://openalex.org/W2114949397","https://openalex.org/W2121349530","https://openalex.org/W2121413294","https://openalex.org/W2121960810","https://openalex.org/W2126054772","https://openalex.org/W2132139555","https://openalex.org/W2132617827","https://openalex.org/W2134314425","https://openalex.org/W2136138120","https://openalex.org/W2136259692","https://openalex.org/W2136674950","https://openalex.org/W2138190786","https://openalex.org/W2140375432","https://openalex.org/W2140794817","https://openalex.org/W2145783464","https://openalex.org/W2145859123","https://openalex.org/W2147991226","https://openalex.org/W2150315515","https://openalex.org/W2152390280","https://openalex.org/W2154005460","https://openalex.org/W2157527766","https://openalex.org/W2160234571","https://openalex.org/W2160337287","https://openalex.org/W2161832050","https://openalex.org/W2164376387","https://openalex.org/W2166443701","https://openalex.org/W2167016517","https://openalex.org/W2169783774","https://openalex.org/W2171165571","https://openalex.org/W2171176064","https://openalex.org/W2172068406","https://openalex.org/W2273578923","https://openalex.org/W2321716269","https://openalex.org/W2334899541"],"related_works":["https://openalex.org/W2166064032","https://openalex.org/W3159471506","https://openalex.org/W1968705853","https://openalex.org/W2811338039","https://openalex.org/W4281970279","https://openalex.org/W4315491990","https://openalex.org/W2886699794","https://openalex.org/W2893867690","https://openalex.org/W4387408008","https://openalex.org/W1983943459"],"abstract_inverted_index":{"Type":[0],"2":[1],"diabetes":[2],"(T2D)":[3],"is":[4,9,27,313,354,420],"a":[5,122,186,220,228,326,391],"metabolic":[6,139,413],"disorder":[7],"that":[8,143,265,288,312,339,437,474],"characterized":[10],"by":[11,315,350,357],"high":[12],"blood":[13,368],"glucose":[14],"in":[15,56,78,132,178,189,197,219,235,283,325,331,390,400,408,470,485,502,508],"the":[16,51,72,91,128,163,190,286,293,305,332,340,409,425,434,441,444,460],"context":[17],"of":[18,33,53,74,99,112,130,135,165,172,205,231,272,278,281,295,307,329,342,360,382,396,404,412,430,462,477,489],"insulin":[19,351],"resistance":[20],"and":[21,35,43,63,71,76,97,103,115,137,150,153,159,174,195,207,233,366,388,417,428,448,465,493,510],"\u03b2-cell":[22],"dysfunction.":[23],"Excessive":[24],"body":[25],"weight":[26,182,217,236,268],"associated":[28,108,213,253,481,499],"with":[29,109,214,227,254,467,482,500],"an":[30,270],"increased":[31,110,380],"risk":[32,69,111,134,164,280,311,346,381,386,395],"T2D":[34,75,114,136,251,282,296,310,330,345,383,398,416],"other":[36],"major":[37,175],"chronic":[38],"diseases":[39],"including":[40,60,415],"cardiovascular":[41],"disease":[42],"certain":[44,208],"cancers.":[45],"The":[46],"current":[47],"work":[48],"focuses":[49],"on":[50,256,309,318,344],"identification":[52],"systemic":[54],"biomarkers":[55,255],"various":[57],"biological":[58,320,405,431],"samples,":[59],"serum,":[61],"urine,":[62],"DNA,":[64],"as":[65],"indicators":[66],"for":[67],"environmental":[68],"factors":[70],"development":[73],"obesity":[77],"different":[79,257,319],"human":[80],"populations.":[81],"Environmental":[82],"endocrine-disrupting":[83],"chemicals":[84],"(EDCs)":[85],"have":[86,263,450],"been":[87,452],"shown":[88,264],"to":[89,106,125,180,244,292,379,423,515,521],"affect":[90,162],"biosynthesis,":[92],"secretion,":[93],"transport,":[94],"binding":[95],"action,":[96],"metabolism":[98],"endogenous":[100],"sex":[101,361,447],"hormones,":[102],"were":[104,212,497],"suggested":[105],"be":[107],"developing":[113,166,397],"obesity.":[116,418],"In":[117,300,455],"Chapter":[118,198,301,456],"1,":[119],"we":[120,184,303,458],"conducted":[121,185],"meta-analysis":[123],"study":[124,328],"comprehensively":[126],"assess":[127],"role":[129,230],"EDCs":[131,155],"affecting":[133],"related":[138],"traits.":[140],"We":[141,337,472],"found":[142,338,473],"both":[144],"persistent":[145],"(including":[146,156],"dioxin,":[147],"polychlorinated":[148],"biphenyls,":[149],"chlorinated":[151],"pesticides)":[152],"non-persistent":[154],"bisphenol":[157],"A":[158],"phthalates)":[160],"may":[161],"T2D.":[167],"To":[168],"evaluate":[169],"urinary":[170,203],"concentrations":[171,204],"BPA":[173,206,232],"phthalate":[176,210],"metabolites":[177,211],"relation":[179,445],"prospective":[181,187,240,261,371],"change,":[183],"analysis":[188],"Nurses'":[191],"Health":[192,334],"Study":[193],"(NHS)":[194],"NHSII":[196],"2.":[199],"Our":[200],"data":[201,224,241,372],"suggest":[202],"individual":[209],"modestly":[215],"greater":[216,394],"gain":[218],"dose-response":[221],"fashion.":[222],"These":[223,370],"are":[225,242,297,519],"consistent":[226,435],"potential":[229,316,426,523],"phthalates":[234],"gain,":[237],"although":[238],"more":[239],"needed":[243],"corroborate":[245],"these":[246],"observations.":[247],"\\tIn":[248],"previous":[249],"studies,":[250],"was":[252,276,479],"molecular":[258],"pathways.":[259],"Earlier":[260],"studies":[262,514],"low":[266],"birth":[267],"(LBW),":[269],"indicator":[271],"intrauterine":[273],"growth":[274],"restriction,":[275],"predictive":[277],"higher":[279],"adulthood,":[284],"but":[285,506],"pathways":[287,321],"lead":[289],"LBW":[290,308,343,378],"individuals":[291],"onset":[294],"still":[298],"unclear.":[299],"3,":[302],"assessed":[304],"effect":[306,341],"explained":[314,356],"mediators":[317],"using":[322],"mediation":[323],"modeling":[324],"case-control":[327],"Women's":[333],"Initiative":[335],"(WHI).":[336],"seems":[347],"mainly":[348],"mediated":[349],"resistance,":[352],"which":[353],"further":[355],"circulating":[358,463],"levels":[359,496],"hormone-binding":[362],"globulin":[363],"(SHBG),":[364],"E-selectin,":[365],"systolic":[367],"pressure.":[369],"provide":[373],"quantifiable":[374],"mechanistic":[375],"evidence":[376],"linking":[377],"whilst":[384],"presenting":[385],"stratification":[387],"intervention":[389],"population":[392],"at":[393],"later":[399],"life.":[401],"\\tThe":[402],"process":[403,411],"aging":[406],"involves":[407],"pathogenesis":[410],"disorders":[414],"It":[419],"also":[421],"necessary":[422],"examine":[424],"predictors":[427],"determinants":[429],"aging.":[432],"Despite":[433],"observations":[436,518],"women":[438,505],"outlive":[439],"men,":[440],"mechanisms":[442],"underlying":[443],"between":[446],"longevity":[449],"not":[451,480,507],"fully":[453],"elucidated.":[454],"4,":[457],"examined":[459],"associations":[461],"estradiol":[464,478],"testosterone":[466,495],"leukocyte":[468,483],"TL":[469,484,501],"WHI.":[471],"serum":[475],"concentration":[476],"this":[486],"large":[487],"sample":[488],"postmenopausal":[490],"women.":[491,512],"Total":[492],"free":[494],"inversely":[498],"Asian/Pacific":[503],"Islander":[504],"black":[509],"Hispanic":[511],"Future":[513],"replicate":[516],"our":[517],"warranted":[520],"address":[522],"ethnicity-specific":[524],"relations.":[525]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}